Professional Documents
Culture Documents
Non-pharmacological
• Environmental measures
• Hydration (fluids)
• Hydrotherapy (sponging)
Pharmacological therapy
• Drugs: paracetamol, ibuprofen,mefenemic
acid
Fever of Unknown Origin
Definitions: Fever (rectal temp > 38° C)
more than 3 weeks duration documented by
health care provider, for which the diagnosis
could not be established even after 1 week
of investigations in a hospital setting.
Nosocomial unknown: pt developed fever
after hospital admission
Neutropenic unknown: fever in a pt with
Absolute Neutrophile Count< 500
Etiology
Infections
Enteric fever, TB, HIV, chronic hepatitis,
occult abscess, osteomyelitis, infective
endocarditis , kala-azar , brucellosis
Malignancy: Leukemia, Hodgkins
lymphoma.
Autoimmune: Systemic Lupus
Erythematous, Poly Arthritis Nodosa,
Inflammatory Bowel Disease, Kawasaki
disease
Approach to Unknown Fever
• Evaluation of fever -- onset, type,
duration , character, pattern, course of
illness
• Clinical examination
• Laboratory tests
1st LINE – CBC, peripheral smear,
malaria parasite, widal, CXR , ESR , urine
routine & cultute,blood culture, mantoux
test, LFT , RFT, USG abdomen, special
investigation depending on the clinical clue
2nd LINE – HIV , CT chest and
abdomen ,bone marrow examination , 2D
echo , check complement levels, Ig
levels,specific tissue biopsy, serological
tests for HBsAg , brucellosis, and infectious
mononucleosis
• Its usually possible to determine the
etiology in most cases
• In a small number of cases no cause is
found. In such cases periodic assessment is
done .
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