HEMOGLOGIN AND MYOGLOBIN )

PRESENTED BY: ROOSHANA SADAQAT

(2022138024 )

PESENTED TO: Dr. BUSHRA

BS-ZOOLOGY
(SEMESTER-V)
BIOCHEMISTRY
DEPARTMENT OF ZOOLOGY

GOVT. GRADUATE COLLEGE (W) GULBERG, LAHORE.

 O2 carrying
proteins

Hemoglobin Myoglobin

It serves as It serves as

O2 carrier CO2 carrier O2 storage O2 carrier

Gives red color to blood Carries CO2 to lungs. Store O2 Also carry O2 to muscles.
and carries oxygen to cells.
 Abbreviation abc
def
Hb

Carry O2 from lungs and

Hemoglobin
Direction
supply it to tissues and all
cells of the body.

Molecular 64kDa (kilo Daltons)

weight

Functions Carry O2 and CO2.

Presence Present in blood of all

vertebrates.

Quaternary Structure
Structure Protein, Heterotetramer.
 Hemoglobin Molecule

BETA BETA
CHAIN 1 CHAIN 2

ALPHA ALPHA
CHAIN 1 CHAIN 2
 Oxygen Transport Chain

Alveolar- Capillary-
Capillary Flow of Mitochon
O2 HbO2 to drial O2
diffusion tissues binding

Flow of O2 Hb-O2 HBO2

to alveoli binding dissociate
-on
Forms of Hemoglobin
 Hemoglobin Deficiency Disorders
Sickle Cell Anemia
01
1- Sickle cell disease
2- Sickle cell trait
Thalassemia Spherocytosis
1- Hereditary disorder 1- Inherited disorder
02 2- Less hemoglobin tan
normal
03 2- RBCs are round
instead of disk like
 Myoglobin
Present in Tertiary structure Carries oxygen
Muscles(cardiac protein with one to body cells
and skeletal) polypeptide chain. and tissues.

05
03
01

02

04
Monomeric Stores O2
molecule
Heme
 Oxygen Supply Chain

01 O2 binds with Fe2+ (of heme in hemoglobin) in alveoli

of lungs.

Oxyhemoglobin transport O2 to myoglobin in muscles.

02

03 O2 is stored in storing protein of muscles called

Myoglobin.

Oxymyoglobin provide the muscles with O2 when and

04
where needed.
Forms of Myoglobin
 Hemoglobin Myoglobin
STEP STEP
A heterotetramer protein with A monomeric protein of
01
2 alpha and 2 beta chains and molecular weight 16.2 kDa. 04
molecular weight of 64 kDa.

STEP Binds with only 1 O2 STEP

Binds with 4 O2 molecules
02
however, it has low affinity to
bind O2 . Also capable to
tightly bound with O2 .
STEP
molecules in spite of having
having high affinity to bind
05
O2 . Incapable of tight
bounding with O2 .
STEP

03
Present in Blood stream and
has 3 types of cells i-e
Present in Muscles and is of 06
single type of cell.
HbA,HbA2 and HbF.