PLLA Collagen Stimulator - Aesplla

© ST INDONESIA.
All rights reserved

The Different
PLLA, PDLA & PDLLA?
© ST INDONESIA. All rights reserved

What is PLA?
Polymers of lactic acid derived from plants
(starch of potatoes, corn, etc.)
Particles size: 30~60 ㎛ , 140k Dalton
Poly L Lactic Acid (PLLA) biodegradable

Category :
Poly D Lactic acid (PDLA)
biocompatibility
It has been used as a material for medical sutures
and as a wound covering agent Collagen no tolerance
production promoter

Poly(lactic acid) (PLA) is a biocompatible material with excellent mechanical strength, easy processability, and good
biodegradability [8–11]. For these reasons, PLA has been widely used in tissue engineering, drug delivery, surgical sutures, and
orthopedic repair material
PLLA PDLA PDLLA

Poly-L-Lactic Acid Poly-D-Lactic Acid Poly-DL-lactic Acid
Has slower biodegradation rates compared Breaks down in the body relatively
Better chemical stability
toesopption the other forms of PLLA quickly
PDLA does not decompose when exposed

Low grade inflammation
Much longer resorption time to certain enzymes that can hydrolyze both
PLLA and PDLLA
Stimulate collagen 1,4 or 1,1 times Better keratinocytes proliferation (as water
higher than PDLA or PDLLA content protection) than PLLA
Better fibrioblast proliferation than PDLA High grade inflammation
Degraded moderate, maintain effect of

promoting collagen regeneration for a long Worst collagen regeneration
time
PLLA vs PDLA
PLLA PDLA
is like solid sponge is like porous sponge
The Different
Collagen Stimulator & Filler?

Collagen Stimulator Dermal Filler
PLLA vs PDLA
PLLA(L-Form) PDLA (D-Form)
PLLA looks solid and PDLA looks like pressed cotton candy. It means that PDLA can make small volume formation and
PLLA can make bigger volume formation
aesPlla Composition &
Benefit?

aesPlla ® Composition
Components
Carboxymethyl Total
Product Poly-L-lactic acid (PLLA) Mannitol volume
cellulose (CMC)
(mg)
mg % mg % mg %
aesPlla ® 150 41.1 90 24.7 125 34.2 365
PLLA : Collagen Stimulator

CMC : Pengental, Penstabil dan Pengikat
Mannitol : Meningkatkan Liofilisasi Partikel (untuk menghasilkan sebuah produk bubuk yang stabil)

What is aesPlla ® ?
• aesPlla Ⓡ is an injectable poly-L-lactic acid (PLLA)
collagen stimulant for face and body
• aesPlla Ⓡ is CE approved & have already used in Europe etc.
• aesPlla Ⓡ ‘s main ingredient PLLA provides results of gradual volume

effects with long lasting more than 2 years

Strong point aesPlla?

1. Safe
PLLA has been used for more than 30 years in the medical field
2. Natural
Stimulates the natural production of collagen
3. Long-lasting
provides long lasting effects more than 2 years
4. Versatile
Can be used in many indications such as face and body
5. Easy and fast dilution

Injection after 30 minute dilution
6. Appropriate dosage of a vial

Suitable amount for a single treatment

Safety of aesPlla ® - no nodule by streamlined shape particle
Particle type
**SEM micrograph, solution form
aesPlla ® Product S aesPlla ® Product S
x300
x100
x2000
x500
x5000
Granulated powder of aesPlla ® has streamlined shape which can reduce side effects like nodules, so aesplla is the safer.
*Manufacturer research data

How long dilution time of
aesPlla?

How to dilute aesPlla?

Reconstitution
Draw sterile water or normal saline into the syringe
Add sterile water to the aesplla vial

• For aesPlla ® : 9 ml
Shake the vial for and then let the vial stand for at least
30 minutes to ensure complete hydration
Strongly agitate prior to use
*Quick dilution – 30 minutes

Where are the area
indicated for aesPlla?

aesPlla ® indications
Face Décolletage Buttocks Thighs Cellulite Upper arms Hands

Forehead and neck augmentation
temporal area reshaping
cheeks
nasolabial folds

Where is the area
prohibited for aesPlla?

aesPlla ® should not be used in the certain area
aesPlla should not be used in Lips areas

Cellulite indications
aesPlla Ⓡ should NOT be injected into the gluteal

fold (banana fold) to treat cellulite

How about aesPlla
storage?

aesPlla ® storage
Store at room Keep away from

Do not freeze Keep dry
temperature sunlight

How about aesPlla
Post-treatment care?

Post-treatment care
Apply an ice pack Massage the treated area Avoid wearing makeup or applying other skin products
35–45 minutes 5 minutes, 5 times a day, to the injection site
First day at least 2 weeks for 1 week
Minimize exposure to UV light, Avoid swimming or using a sauna Avoid vigorous exercise for
until any initial swelling and redness has resolved for 1 week 1 week

What is contraindication of
aesPlla?

Contraindications
Active inflammation or infection in or near the treatment area
Hypersensitivity to any of the components
Patients who are pregnant, lactating, breastfeeding or under 18 years of age
Do not use in or near the periorbital area and lips
Do not use in eye contour
Patients with known history of or susceptibility to keloid formation or hypertrophic scarring

Mechanism of Plla?

1. Inflamasi
2. 3-4 weeks PLLA dikelilingi
sel mast, makrofag dll
3. 3 months inflamasi
menurun & terjadi
peningkatan jumlah serat
kolagen
4. Peningkatan kolagen terus
terjadi 8-24 bulan
5. 9 bulan PLLA mulai
terdegradasi perlahan,
kemudian diabsorpsi
menjadi CO2 dan H2O

Mechanism of action
1. 2. 3. 4. 5. 6.
Before treatment aesPlla (PLLA plus Within a few days, aesPlla begins to After about 6 weeks, PLLA particles
sterile water) the water is gradually promote visible improvement gradually degrade
injected in the area absorbed collagen production can be seen over time
Collage
n PLLA

Thank You

PLLA Collagen Stimulator - Aesplla

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© ST INDONESIA.

All rights reserved

© ST INDONESIA. All rights reserved

Particles size: 30~60 ㎛ , 140k Dalton

Poly L Lactic Acid (PLLA) biodegradable

© ST INDONESIA. All rights reserved

PLLA PDLA PDLLA

PDLA does not decompose when exposed

Better fibrioblast proliferation than PDLA High grade inflammation

Degraded moderate, maintain effect of

© ST INDONESIA. All rights reserved

PLLA(L-Form) PDLA (D-Form)

© ST INDONESIA. All rights reserved

aesPlla ® 150 41.1 90 24.7 125 34.2 365