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LIFS2210
Introduction of Biochemistry
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• Table of Contents
• Part I The Realm of Biochemistry
• Chapter 1 The Scope of Biochemistry
• Chapter 2 The Matrix of Life: Weak Interactions in an Aqueous Environment
• Chapter 3 The Energetics of Life
• Part II Molecular Architecture of Living Matter
• Chapter 4 Nucleic Acids
• Chapter 5 Introduction to Proteins: The Primary Level of Protein Structure
• Chapter 6 The Three-Dimensional Structure of Proteins
• Chapter 7 Protein Function and Evolution
• Chapter 8 Proteins in Motion: Contractile Systems and Molecular Motors
• Chapter 9 Carbohydrates: Sugars, Saccharides, Glycans
• Chapter 10 Lipids, Membranes, and Cellular Transportation
• Part III Dynamics of Life: Catalysis and Control of Biochemical Reactions
• Chapter 11 Enzymes: Biological Catalysts
• Chapter 12 Chemical Logic of Metabolism
• Part IV Dynamics of Life: Energy, Biosynthesis, and Utilization of Precursors
• Chapter 13 Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate
Pathway
• Chapter 14 Citric Acid Cycle and Glyoxylate Cycle
• Chapter 15 Electron Transport, Oxidative Phosphorylation, and Oxygen Metabolism
• Chapter 16 Photosynthesis
• Chapter 17 Lipid Metabolism I: Fatty Acids, Triacylglycerols, and Lipoproteins
• Chapter 18 Interorgan and Intracellular Coordination of Energy Metabolism in Vertebrates
• Chapter 19 Lipid Metabolism II: Membrane Lipids, Steroids, Isoprenoids, and Eicosanoids
• Chapter 20 Metabolism of Nitrogenous Compounds: Principles of Biosynthesis, Utilization, and Turnover
• Chapter 21 Metabolism of Nitrogenous Compounds: Amino Acids, Porphyrins, and Neurotransmitters
• Chapter 22 Nucleotide Metabolism
• Chapter 23 Mechanisms of Signal Transduction
• Part V Information
• Chapter 24 Genes, Genomes, and Chromosome
• Chapter 25 DNA Replication
• Chapter 26 DNA Restructuring: Repair, Recombination, Rearrangement, Amplification
• Chapter 27 Information Readout: Transcription and Post-transcriptional Processing
• Chapter 28 Information Decoding: Translation and Post-translational Protein Processing
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• Chapter 29 Regulation of Gene Expression
Review lecture notes
Course website - CELT (https://canvas.ust.hk)
• Reference books
• Biochemistry (7th edition) by Berg, Tymoczko and Stryer
• Lehninger Principles of Biochemistry (6th edition) by Nelson
and Cox
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1. What is Biochemistry ?
• Biochemistry is the application of chemistry to the
study of biological processes at the cellular and
molecular level.
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Principles of Biochemistry
• Cells (basic structural units of living organisms) are highly
organized and constant source of energy is required to maintain
the ordered state.
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How does biochemistry impact you?
• Medicine
• Agriculture
• Industrial applications
• Environmental applications
• etc 6
2. Molecular organization of Life
• elements
• simple organic compounds (monomers)
• macromolecules (polymers)
• supramolecular structures
• organelles
• cells
• tissues
• organisms
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Range of the
sizes of objects
studies by
Biochemist and
Biologist
1 angstrom = 0.1 nm
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The Cell is the Basic Unit of Life
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Many Important Biomolecules are Polymers
supramolecular
membrane protein complex cell wall chromosome
structure
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A. Proteins
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Proteins
supramolecular
structure Enzyme complex
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B. Polysaccharides
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Carbohydrates
monomer glucose
polymer cellulose
supramolecular
structure cell wall
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C. Nucleic Acids
• Polynucleotides
- nucleic acid
biopolymers are
composed of
nucleotide
monomers
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Nucleic Acids
monomer nucleotide
polymer DNA
supramolecular
chromatin
structure
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D. Lipids and Membranes
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Lipids
polymer phospholipid
supramolecular
membrane
structure
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Biomolecules – Structure
Anabolic
Catabolic
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Common theme:
Monomers form
polymers through
condensations
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3. Water
•About 60-90 percent
of an organism is water
Water is used in
most reactions in
the body
Water is called
the universal
solvent
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Hydrogen Bonding in Water
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Nonpolar Substances Are
Insoluble in Water
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Noncovalent forces
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A. Charge-Charge Interactions (Ion Pairing)
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B. Hydrogen Bonds
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C. Van der Waals Forces
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D. Hydrophobic Interactions
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Hydrophobic effect
Water H2O
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The Chemical Elements of Life
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