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Z E

S I
TO
S
IT
L IM

© 2016 Paul Billiet ODWS


VOLUME
Volume determines the amount metabolism
in the cytoplasm
Metabolism will require import of precursors
Metabolism will result in the export of
secretions
And the export of excretory products.

© 2016 Paul Billiet ODWS


SURFACE AREA
Surface area determines the exchange of
materials between the cell and its environment
Bigger cells will metabolise more
But they will need more surface to support
that metabolism
And the sites of metabolism inside bigger cells
will be further from the surface of the cell.

© 2016 Paul Billiet ODWS


GROWING CELLS

1µm

2µm

3µm

4µm

5µm

© 2016 Paul Billiet ODWS


6µm
HOW ARE SURFACE AREA AND VOLUME
AFFECTED BY GROWTH?
Size
/ µm 1 2 3 4 5 6

Surface
area
6 24 54 96 150 216
/ µm2

Volume
/ µm3 1 8 27 64 125 216

SA/V 6 3 2 1.5 1.2 1

© 2016 Paul Billiet ODWS


COMPARING SURFACE AREA AND VOLUME
CHANGES

© 2016 Paul Billiet ODWS


SURFACE AREA:VOLUME RATIO

© 2016 Paul Billiet ODWS


THE PROBLEM
Bigger cells have a greater metabolism than
smaller cells
BUT bigger cells have a proportionally less
surface for exchange
How to increase surface area without
increasing volume still further?

© 2016 Paul Billiet ODWS


THROW OUT EXTENSIONS

Microvilli of
small intesti
ne epitheliu
m

© 2016 Paul Billiet ODWS


FLATTEN INTO A THIN FILM
Chick blastodisc

© 2016 Paul Billiet ODWS


DIVIDE THE CYTOPLASM INTO SMALLER
VOLUMES
Zygote 8-cell Embryo

Early human em
bryos

© 2016 Paul Billiet ODWS


MULTICELLULAR ORGANISMS SHOW THE
SAME ADAPTATIONS

Flowering plants have an extensive, branched rooting


system to absorb water and minerals

© 2016 Paul Billiet ODWS


MULTICELLULAR ORGANISMS SHOW THE
SAME ADAPTATIONS

Mammals have a long


small intestine with
internal folding to absorb
digested food

C. Candalh, INSERM
© 2016 Paul Billiet ODWS

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