Done by

JANANI.V
JANAKI.R
JANE ROSE.J
CRRI
SATHYABAMA DENTAL
COLLEGE
 RELATIONSHIP BETWEEN
PLAQUE PH AND PEDIATRIC
DRUGS: A RANDOMIZED
CONTROLLED TRIAL
DEPARTMENT OF PUBLIC
HEALTH DENTISTRY

GUIDED BY
DR. PAVANI MDS.,
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 AIM
To investigate the effect of three group
of commonly used paediatric
medications on plaque pH after
consumption of those drugs.
HOW
LO GY
DID M ET HO DO

IT
BEGIN????
Study design: it is a single blinded
randomized controlled trial.

Study population: 18 – 25 year adults.

Sample size: 90 subjects who fulfill the

inclusion and exclusion criteria's.
 90 subjects

Antibiotics Analgesics Cough syrups

ARMAMENTARIUM
6 commonly prescribed paediatric
drugs

Endogenous pH determined using

digital pH meter

90 subjects – age group 18 - 25

Refrained from oral hygiene

measures for 24 hours

Plaque collected from molars.

Baseline pH measured

5 ml of test drug – 1 min swish and

spit it.

Plaque pH determined at 0, 10, 20,

30 min
 STATISTICAL ANALYSIS
TESTS DONE

Mixed ANOVA test

Bonferroni post hoc test
Wilcoxon signed rank test
Significance level 0.05
 Cough syrups Antibiotics
6.9 6.8
6.8 6.7
6.7 6.6
6.5

pH
6.6
pH

6.5 COSCOPIN 6.4 AUGMENTUM

6.4 ZEDEX-P 6.3 OFLOXACIN
6.3 6.2
Base 0 10 20 30 Base 0 10 20 30
Time Interval Time Interval

Analgesics
7
6.5
6
pH

CROCIN
5.5
P-250
5
Base 0 10 20 30

Time Interval
Graph representing the comparison of drop in plaque pH between all drug group

7
6.8
6.6
6.4
6.2
pH

6
5.8
5.6
5.4
5.2
Base 0 10 20 30

Time Interval

COSCOPIN ZEDEX-P AUGMENTUM OFLOXACIN CROCIN P-250

 DISCUSSION:
 We found that endogenous pH of all drugs were
acidic with cough syrup being below critical pH.
Similarly,
 Lima et al showed that 74.2% of the drugs examined
had pH lower than 5.5.
 Sunitha et al showed that endogenous pH of all the
drugs considered were acidic in nature with cough
syrup being below the cariogenic critical pH .
 Rekola showed that drugs which are sweetened
produced drop in plaque pH.
Our results of the fall in pH after the drug was ingested
showed a high similarity as in the studies conducted earlier
by sunita et al, rekola m, srinivas and reddy.
The liquid medicaments have a great potential for causing
dental caries.
Further health workers should be informed regarding the
cariogenic potential of liquid medicaments so as to guide
the parents to introduce oral hygiene after consumption.
 CONCLUSION :
we conclude that pH level is significantly
different among the drug groups. pH level is
low in analgesics than Antibiotics and cough
syrup. Also, pH level significantly drops till
the 20 minutes from the time of
consumption of drugs when compared to
the base pH.
RECOMMENDA
TION
!!!!!!
These sweeteners along with their low
endogenic pH form a high cariogenic
formulation. Thus, nonsucrose
(noncariogenic) or sugar-free medications
are needed to be prescribed along with
proper oral hygiene care to the children
under medication.
REFERENCES
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