LIPIDOL

Ethiodized Oil
MD SAIFUL ISLAM MUNNA
Sr. Executive (PMD)
WHAT IS LIPIDOL ?
 Lipiodol, also known as ethiodized oil, is a poppyseed oil
used by injection as a radio-opaque contrast agent that is
used to outline structures in radiological investigations.
 It is used in chemoembolization applications as a contrast
agent in follow-up imaging.
 HCC STATUS IN BANGLADESH
 Bangladesh is one of the countries facing huge
burden of hepatocellular carcinoma (HCC).
Hepatocellular carcinoma is the third commonest
cancer in the country and it is just behind to cancer
of the lung and cancer of the stomach.

Noor-E-Alam SM. Management of Hepatocellular Carcinoma: Bangladesh Perspective. Euroasian J Hepato-

Gastroenterol 2018;8(1):52-53.
IS HCC TREATABLE?
 Most people who develop HCC
have cirrhosis, which is a
build-up of scar tissue due to
years of liver damage. Since
HCC usually grows slowly in
its early stages, it can often
be cured if discovered
early enough.
Liodol ® - Imaging Tumors in Adults with Known HCC
LIPIODOL IN HCC
PATIENTS
 Lipiodol® is indicated for selective hepatic intra-arterial use
for imaging tumors in adults with known HCC.
LIPIODOL INJECTION IN
LIVER CT
• Has a high affinity for primary hepatic tumors
• Moves as oil droplets in the feeding vessels of hepatic
tumors
• Deposits in the tumor when injected into the hepatic artery
• Retained in 85% of Hepatic tumors
• Prolonged retention in liver tumors
INDICATION AND USAGE OF
LIPIDOL
 LIPIODOL® ( ethiodized oil) injection is a prescription oil-
based radio-opaque contrast agent indicated for:
 hysterosalpingography in adults
 lymphography in adult and pediatric patients
 Selective hepatic intra-arterial use for imaging tumors in
adults with known hepatocellular carcinoma (HCC)
EFFICACY OF LIPIDOL
AIMS
 To evaluate the sensitivity & specificity of the techniques of
Lipiodol® injection

 Materials and Methods: Prospective, single center

study

 60 patients suspected of having an HCC

 Lipiodol® was performed 6-13 days following intra-arterial
injection of Lipiodol
OBJECTIVES
 Lipiodol® was performed 6-13 days following intra-
arterial injection of Lipiodol
• To investigate the specificity of Lipiodol®
• Evaluate whether Lipiodol® can detect an HCC while
it is small and asymptomatic
• Evaluate whether if resectability rate can be
improved
• To analyze the pattern of uptake of Lipiodol® by the
tumo
RESULTS
 The size of the HCCs ranged from 0.8 cm to 11 cm in
diameter with the median size at 2.2 cm.
 Four uptake patterns were found: homogeneous,
patchy, no uptake, faint uptake by the liver.
 In the diagnosis of HCC, Lipiodol®-CT had an overall
sensitivity of 97.1%, an accuracy of 88.3% and a
specificity of 76.9% [...]
DETECTION OF HCC

82-year-old man with 4-cm hepatocellular carcinoma (HCC).

CONCLUSION
 For high risk patients, Lipiodol® injection is useful in the
detection of HCCs while they are relatively small.
 In view of its ability to demonstrate daughter nodules at
times not seen by conventional CT or hepatic angiography,
the technique helps to determine whether the tumor is
suitable for surgical resection or
 Whether it would better treated with chemotherapy,
including trans-arterial chemo-embolization.
CONCLUTION (CONT,)
 Lipiodol CT has higher diagnostic sensitivity for small
HCC lesions. This technique may help physicians
make intraprocedural decisions to provide patients
with earlier treatment.