Professional Documents
Culture Documents
•Eat five or more servings of a variety of vegetables and fruits each day.
• High intake of red meat including beef, pork, veal, and lamb, is
associated with an elevated risk of colorectal cancer in both men
and women in 6 studies…
– prospective study 47,949 U.S. male health professionals
• 205 cases of colon cancer after 6 years of follow up
• Intakes of total fat, saturated fat, and animal fat were not related to risk of
colon cancer
• Men who ate beef, pork, or lamb as a main dish five or more times per week
had a relative risk of 3.57 compared to men eating these foods < once per
month
• Other sources of animal fat, including dairy products, poultry, and fish as
well as vegetable fat, were slightly inversely related to risk of colon cancer.
• No clear association existed between fiber or vegetable intake and risk of
colon cancer.
Red Meat
• prospective study 88,751 women 34 to 59
years
• 150 cases of colon cancer after 6 years of follow up
• After adjustment for total energy intake, animal fat was
positively associated with the risk of colon cancer
• The relative risk of colon cancer in women who ate beef,
pork, or lamb as a main dish every day was 2.49 as
compared with those reporting consumption < once a
month
» Processed meats and liver were also significantly
associated with increased risk, whereas fish and chicken
without skin were related to decreased risk.
» A low intake of fiber from fruits appeared to contribute to
the risk of colon cancer, but this relation was not
statistically independent of meat intake
Red meat
• European Prospective Investigation into cancer
and nutrition (EPIC study)
– 478 040 men and women from 10 European countries
between 1992 and 1998.
– 1329 incident colorectal cancers were documented
after a mean follow-up of 4.8 years
– colorectal cancer risk is positively associated with
high consumption of red and processed meat and
support an inverse association with fish intake
Fruits and Vegetable
• A large number of potentially anticarcinogenic
agents are found in fruits and vegetables
• Retrospective studies and small prospective
studies have suggested a dose-response
relationship between fruit and vegetable intake
and the prevention of cancers.
– Soy decreases prostate cancer in men and breast
cancer in Asian women
– Flavonoids (tomatoes, green peppers, berries, and
citrus fruits) may decrease breast cancer
– Lycopene (tomatoes) may decrease prostate cancer
Epidemiologic Studies of
Lycopene and Cancer Risk
Cancer Type of Study Reference
Concerns
Growth enhancement of human mammary tumors transplanted into mice
that were fed soy or isoflavonids (Hsieh, et al. Cancer Res. 58:3833, 1998).
Soymilk Intake & Prostate
Cancer Risk
1.0
0.9
0.8
Relative Risk
0.3*
0 <1 1 >1
confidence interval 0.1-1.0
Daily Intake (servings)
Cancer Causes and Control 9: 553, 1998
Fruits and Vegetables
• Large prospective studies have not found such a benefit:
– 71,910 women from the Nurses' Health Study and 37,725 men in the Health
Professionals' Follow-up Study found no association between fruit and vegetable
intake and risk of cancer (for an increment of five servings daily, relative risk [RR]
1.00, 95% CI 0.95 to 1.05)
– The European Prospective Investigation into Cancer and Nutrition (EPIC) study
examined the association between fruit and vegetable intake and risk of breast
cancer in 285,526 women ages 25 to 70.
• Comparing highest and lowest quintiles, there was no association with intake of fruits
(RR 1.09, 95% CI 0.94-1.25) or vegetables (RR 0.98, CI 0.84-1.14).
• A systematic review of five studies involving a total of 4349 patients concluded that
there was no definitive evidence that increased dietary fiber reduces the incidence or
recurrence of adenomatous polyps within a two- to four-year period
Vitamin E Placebo
7 + Years Treatment
Endpoint Prostate Cancer Incidence
SELECT Trial
• SELECT stands for the Selenium and Vitamin E Cancer Prevention
Trial, a prevention clinical trial to see if one or both of these dietary
supplements prevent prostate cancer.
http://www.cancer.gov/newscenter/qa/2008/selectqa
Vitamins and Micronutrients
• Vitamin D may reduce colon cancer risk by
improving calcium absorption
• Prostate and Breast Cancer: Vit. D +
calcium showed no effect on breast cancer
in 3 trials
• One randomized prospective trial of
calcium + vit D in 1179 women over 4
years has shown decrease in all cancer
types
Am J Clin Nutr. 2008 Mar;87(3):794
Alcohol
Obesity and EBC Outcomes
• Obesity (BMI > 30) associated with poorer DFS and OS in
operable breast cancer
• Evaluation of women with EBC in adjuvant trials of
doxorubicin, cyclophosphamide plus other agents to
determine relationship between obesity and
– Clinical characteristics
– Clinical outcomes
– Clinical outcomes and breast cancer subtype
• ER/PgR-positive, HER2-negative disease
• HER2-positive disease
• Triple-negative disease
ECOG Trials Included in
Analysis
E1199 E5188 E3189
Population • Node positive • ER positive • ER negative
• High-risk node • Node positive • PgR negative
negative • Premenopausal • Node positive
Chemotherapy Cyclophosphamide, Cyclophosphamide, Cyclophosphamide,
doxorubicin, taxane doxorubicin, doxorubicin,
fluorouracil fluorouracil vs
16-wk regimen
Endocrine Tamoxifen ± None vs goserelin None
therapy aromatase inhibitor vs goserelin +
tamoxifen
Patients with 3484 1502 613
BMI data, n
Obesity and Outcomes in
Subgroup Analysis of E1199
E1199 DFS OS
Subgroup HR (95% P HR (95% P
CI) Value CI) Value
ER and/or PgR 1.23 (1.02-1.49) .035 1.46 (1.15-1.85) .002
positive, HER2
negative
ER, PgR, HER2 1.01 (0.77-1.33) .93 1.05 (0.77-1.43) .75
negative (n = 708)
HER2 positive 1.07 (0.77-1.47) .70 0.89 (0.60-1.31) .55
(n = 661)
6-
Antioxidant
reduces
% Apoptosis +
efficacy of
4- cisplatin
2- **
*
0-
Control E CP CP+E
•Eat five or more servings of a variety of vegetables and fruits each day.
Vegetables
• 1 cup of raw leafy vegetables
Grains
• 1 slice bread
• 1 egg
• Increased risk
– large amounts of alpha-linoleic acid and low amounts
of linoleic acid increase risk of nonaggresive cancers
– Calcium?
• No difference
– Selenium
– Vitamin E
• Decreased risk
– Soy milk?
Conclusions by tumor type:
Colon cancer
• Decreased Risk
– Fish (men and women)
– Chicken without skin (women)
– Calcium and Dairy (men and women)Red meat
increases risk in men and women
• No difference
– Fiber
• Increased Risk
– Red meat (men and women)
– Processed meat
– Liver
– High glycemic load (men and women)
Conclusions by tumor type:
• Ovarian cancer
– Dairy may increase risk??
• “All cancers”
– Calcium + vit D
Just when I knew all of life’s answers,
They changed all the questions!!
Lifestyle changes
Caloric
Restriction in
Yeast causes
silencing of
genes and
extended life
span (Guarente
and Kenyon
Nature 2000;
408:255
Colon Cancer and Exercise
More is Not Always Better: Energy Intakes and
Expenditures Are Linked to Health!
Caffeine
Tea (Camellia sinensis)
Crushed tea leaves
Polyphenol oxidase
Oxidation,
r ied es Polymerization
D av
Le
a
Te
HO
Green Tea OH
Black Tea
30-40% Catechins HO O
R1
3-10% Catechins
3-6% Caffeine 2-6% Theaflavins
~310 mg polyphenols OR 2 > 20% Thearubigens
per 6 ounces 3-6% Caffeine
OH
~340 mg polyphenols
Yang CS. Personal Communication
per 6 ounces
Tea and Cancer Prevention
Liver Skin
Oral
Esophagus
Prostate
Mammary
Stomach Lung
-6
-12
TT Tt tt TT Tt tt
Vitamin D Receptor Genotype
Rapuri et al. Am J Clin Nutr 2001 Nov;74(5):694-700
Prospective cohort study with 41,837
women age 55 to 69, examined 127
food items. “The strongest
association in the present study was
that for garlic consumption, with an
approximate 50% lesser risk
associated with high consumption.”
Steinmetz et al. Amer. J. Epidemiology
139:1, 1994
60 seconds
750 a
DNA Adducts
500
b b
250
0
Control Peel/ Microwave/ Peel/
Crushed Crushed
Song and Milner J Nutr 1999;129:657-61
How Should We Consume Bioactive Food Components?
MARKET STAGE 3-DAY SPROUTS
BROCCOLI
3 grams
FREEZE-DRIED
SPROUT EXTRACT
150 grams
150 mg