COVID-19 Guidelines

Use of Directly Acting Antivirals in Adults

COVID-19 Guidelines
Use of Directly Acting Antivirals in Adults
Drug-Drug Interactions
Drug-Drug Interactions
Drug-Drug Interactions
Drug-Drug Interactions
Drug-Drug Interactions
Drug-Drug Interactions
DDI Resources for COVID-19 Antivirals
The Liverpool DDI Tool
www.covid19-druginteractions.org
DDI Searches Returned
Liverpool Tool
Mixpanel Stats
Prevalence of DDIs With COVID-19
Antivirals
Prevalence of DDIs by Type
Prevalence of DDIs by Type
Ritonavir Is a Mixed Inducer and Inhibitor
Ritonavir Is a Mixed Inducer and Inhibitor
Ritonavir Is a Mixed Inducer and Inhibitor
Beyond the COVID-19 DDI Tool
Not Problematic/Mostly Manageable DDIs
Not Problematic/Mostly Manageable DDIs
Not Problematic/Mostly Manageable DDIs
Not Problematic/Mostly Manageable DDIs
Problematic/Challenging DDIs
Problematic/Challenging DDIs
Additional DDI Considerations
Prolonged and Repeated Courses of NMVr
Prolonged and Repeated Courses of NMVr
Prolonged and Repeated Courses of NMVr
Prolonged and Repeated Courses of NMVr
Ensitrelvir SCORPIO Trial Primary Endpoint
Time to Resolution of 5 COVID-19 Symptoms
Ensitrelvir SCORPIO Trial
Long COVID Symptoms
ENS Metabolism and Effect on Drug-
Metabolizing Enzymes
Fraction of CYP3A4 Metabolism and
Magnitude/Duration of DDI With ENS
Fraction of CYP3A4 Metabolism and
Magnitude/Duration of DDI With ENS
Beyond the COVID-19 DDI Tool
Patient Case 1
Patient Case 1
March 2023
Patient Case 1
April 2023
Patient Case 1
April 2023
Patient Case 1
April 2023
Administration in Cases of Swallowing
Difficulties
COVID-19 Drug Interactions
Patient Case 2
Patient Case 2
COVID-19 Drug Interactions (cont)
COVID-19 Drug Interactions (cont)
COVID-19 Drug Interactions (cont)
COVID-19 Drug Interactions (cont)
COVID-19 Drug Interactions (cont)
COVID-19 Drug Interactions (cont)
Antiviral Dose Recommendations for Patients
With
Kidney Impairment
Tacrolimus
Tacrolimus
Tacrolimus-Related Case Reports
Tacrolimus
Tacrolimus
Demystifying COVID-19 Drug Interactions
Demystifying COVID-19 Drug Interactions
Thank You