CHEMISTR

Y
 CATALYST

CATALYSIS uponthose addition the rate of reactn increses. The phenomenon

is called a's: catalysis.

• catalyst; the decrese the rate of reactn

→ Inhibitor.

Exothermic reaction

Ea- Activation energy

Activation energy is towered in presence

of catayst 4 an alternate pathway is followed which increases
the rate ofreaction.
CRITERIA FOR
CATALYST
1. Activation energy décrease in presence of catalyst.

2. Rate of reaction increases as the temperature increases but activation

energy remain the same 4 the probability of finding molecule having energy >
Activation energy increses.

3 After, completion of reaction masse chemical property of catalyst remains same

S+E P+E
3ptE (enzymen catalyst.)
 4. IN PRECENCE OF CATALYST OR ABSENCE OF CATALYST; KEG REMAINS
SAME

k1
S P KEQ=K1/K2
k1

k1
S+E P+E KEQ=K1/K2
k1

5) SELECTIVITY:

A perticular catalyst can catalyze a perticulou reaction

6) EFFICIENCY

A Small amout of catalyst can trans form a huge no. of substrate into product.

7) TURN OVER NUMBER: MEASURING THE EFFICIENCY OF

CATALYSIS REACTION. THE MAXIMUM NO. OF REACTANT
MOLECULES TRANSFORMED INTO THE PRODUCT PER ACTIVE SITE
OF CATALYST INA DEFINITE TIME IS CALLED TURN OVER NUMBER.

IF IT IS IN UNITTIME IS CALLED
number.)s called turn'over frequency
ENZYME
CATALYSIS
ENZYME CATALYSIS:

protein → biological catalyst criteria for enzyme

catalysis is. same as catalysis

coo - [ H+] CONPH coo H ( cationic form)

NH + NH3+
3
[H
+ ] PH

co -
2

NH2 ( anionic form)

ENZYME INHIBITION REACTION: LEIR]
Any Foregine molecule bind with enzymes decreses the activity
afenzumes by partially or fully.

02 TYPE OF REACTION

1) REVERSIBLE ( EIR)

INHIBITION BIND WITH ENZYME BY VDW FORCE

- NO CHEMICAL BOND

1) IR - REVERSIBLE ( EIR)

THERE IS CHEMICAL BOND BETHENZYME & INHIBITION

 REVERCIBLE EIR

competeive un-competeive non-competeive mixed inhibition

COMETETIVE :
K1 K2
E+S ES E + PDT

K3 + I

EI+S
UNCOMPETETIVE
INHIBITION

REACTION

K1 K2
E+S ES PDT + E
K-1

K3 +I

ESI
NON COMPETETIVE
INHIBITION
REACTION

K1 K2
E+S ES PDT + E
K-1
K4 +I
K3 +I

K5 K6
E+S ESI PDT + E
K-5
THAN
K
YOU!