Name _________________________ Date ________________

Section ______________________ Group No. ___________

Exercise No. 9
_______________________________________________________________
M.O. #____________

MARY IMMACULATE PHARMACY

Fr. Selga St.
Davao City
MANUFACTURING ORDER

Product: VIT. BI COMPLEX SYRUP Manufacturing:

Batch Size ________________ Date Started___________
Batch Number ______________ Date Finished__________
Expiry Date _______________
---------------------------------------------------------------
Control Item Ingredients Amount per X –
Number Code # 100 liters
_______ ______ Vitamin B1 100 g 50% ________
_______ ______ Vit. B2 Sodium 180 g 35% ________
Phosphate
_______ ______ Vit. B6 35 g 15% ________
_______ ______ Vit. B12 200 mg 100% ________
_______ ______ Niacinamide 1.125 kg 25% ________
_______ ______ D- Phanthenol 125 g 25% ________
_______ ______ Disodium Edetate 100 g ________
_______ ______ Thiourea 100 g ________
_______ ______ Methyl Paraben Na 200 g ________
_______ ______ Propyl Paraben Na 20 g ________
_______ ______ Sodium Benzoate 100 g ________
_______ ______ Sodium Chloride 25 g ________
_______ ______ Ferric Chloride 5 g ________
_______ ______ Sorbitol 10 g ________
_______ ______ Propylene Glycol 1 lit. ________
_______ ______ Sugar 33.5 kg ________
_______ ______ Colour Ponceau 4R 50 g ________
_______ ______ Essence 500 ml ________
_______ ______ Purified Warer q.s. 100 liters ________
---------------------------------------------------------------
Manufacturing Specification:
1. pH range = 4.0 to 4.2
2. Fill in 60 ml Amber Bottle.
4. Weight per ml 1.26
5. Cool the syrup before the addition of active ingredients.
Prepared by __________________ Approved by _________________
Date _________________________ Date ________________________

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 MARY IMMACULATE PHARMACY
Fr. Selga St.
Davao City

MANUFACTURING BATCH RECORD

Product: VIT. B COMPLEX SYRUP Manufacturing:

Batch Size _________ Date Started _________
Batch Number _______ Date Finished ________
Expiry Date ________
----------------------------------------------------------------

SOP PRIOR TO BATCH PROCESSING

1. All ingredients must be checked and approved by Q.C.

prior to use.
2. All ingredients must be labeled properly. Weights and
volume must agree with the approved M.O.
3. All equipment and accessories must be cleaned.
4. Processing room must be cleaned.
5. Wear necessary protective garments.

CLEAN ROOM AND EQUIPMENT CHECK:

Cleaned by Checked by
Liquid Manufacturing Room __________ ___________
Required Equipment __________ ___________

MANUFACTURING PROCEDURE

1. Prepare the primary syrup, cool and mix with Sorbitol.

Continue stirring during addition of materials.

By _____________________ Checked by __________________

2. Dissolve Sodium Benzoate in water and add to the syrup.

By _____________________ Checked by __________________

3. Dissolve Methyl and Propyl Paraben Sodium in Water and
add to the syrup.

By _____________________ Checked by __________________

4. Dissolve Niacinamide and Vit. B2 Sodium Phosphate in
water and add to the syrup.

By _____________________ Checked by __________________

2
Product: VIT. B COMPLEX Batch size _________ Batch No. ________
SYRUP
----------------------------------------------------------------
6. Dissolve D-Panthenol in water and add to the syrup.

By _____________________ Checked by __________________

7. Dissolve Citric Acid in water and add to the syrup.

By _____________________ Checked by __________________

8. Dissolve thiourea, Disodium Edetate, Vit.B1 and Vit.B6 in

the water and add to the syrup.

By _____________________ Checked by __________________

9. Dissolve Sodium Chloride in water and add to the syrup.

By _____________________ Checked by __________________

10.Dissolve Ferric Chloride in water and add to the syrup.

By _____________________ Checked by __________________

11.Dissolve Vit.B12 in water and add to syrup.

By _____________________ Checked by __________________

11.Add propylene glycol.

By _____________________ Checked by __________________

12.Dissolve the colour in the water and add to the syrup.

By _____________________ Checked by __________________

13.Add the essence.

By _____________________ Checked by __________________

14.Make up the volume to 100 liters (________) with water
and check pH. Adjust of necessary.

By _____________________ Checked by __________________

Product: VIT. B COMPLEX Batch size _________ Batch No. ________

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 SYRUP
----------------------------------------------------------------

BATCH SAMPLING: (Show Computation)

Sample Size ________________

Sampled by _________________

Date __________________
Time __________________

Results _________________________
_________________________
_________________________
Verified by _________________

Disposition _________________

BATCH RECONCILIATION (Show Computation)

Sample ________________ (____________%)

Net Yield _____________ (____________%)

Gross Yield ___________ (____________%)

Loss/Overage __________ (____________%)

COMPUTATION:

Role of Ingredients in the formulation:

4
Ingredients Role of Ingredients
Vitamin B1 _____________________________

Vit. B2 Sodium Phosphate _____________________________

Vit. B6 _____________________________

Vit. B12 _____________________________

Niacinamide _____________________________

D- Panthenol _____________________________

Disodium Edetate _____________________________

Thiourea _____________________________

Methyl Paraben Na _____________________________

Propyl Paraben Na _____________________________

Sodium Benzoate _____________________________

Sodium Chloride _____________________________

Ferric Chloride _____________________________

Sorbitol _____________________________

Propylene Glycol _____________________________

Sugar _____________________________

Colour Ponceau 4R _____________________________

Essence _____________________________

Purified Water q.s. _____________________________