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THE ATOM
The nucleus has protons and
neutrons. Protons are positively charged particles. Neurons are particles without charge. Electrons orbit the nucleus in precisely defined shells and subshells.
Atomic Structure
Atom is smallest part of element that retains chemical properties of that element Atoms are neutral (no charge), but are divisible into smaller elementary or fundamental particles
Not to scale
Nucleus
Atom anatomy
Electron
Proton
Neutron
Nucleons
The Atom
The symbol X is given to any atom. A is the atomic mass number which is
the total number of protons and neutrons. Z is the atomic number which is the number of protons. Atomic number defines the atom.
Atomic Shorthand
Element Atomic Mass A
X Z
Atomic Number
131
I 53
ISOTOPES
If proton number Z changes, the atom
will change (different element). If neutron number change, the element will be the same, but we will have isotopes. By definition; all isotopes of a given element have the same number of protons and differ only in the number of neutrons.
12 6
13 6
14 6
Radioactive Isotopes
Some isotopes are stable (nonradioactive). Some isotopes are unstable (radioactive).
Isotopes
Half-Life
The time required for half of the
radioactive isotope to undergo decay is called the half-life. After 4 half-life's, the residual activity would be 6.25% of original activity, which means there is no significant activity left.
Types of Radiation
Particulate:
Emission of beta particles (electrons) The isotope is converted into different element.
Types of radiation
131
131
I 53
53
(unstable)
Xe 54
(stable)
Photons
Photon is electromagnetic wave. It is part of electromagnetic spectrum. Photons are used in imaging in
radiology (conventional radiography and CT scanning) and in nuclear medicine.
Electromagnetic Spectrum
Frequency (Hz) 105 106 107 108 109 1010 1011 1012 1013 1014 1015 1016 10171018 1019 1020 Wavelength (m) 103 102 101 10-1 10-2 10-3 10-4 10-2 10-3 10-4 10-5 10-6 10-7 10-8 10-9 10-10
Radio/TV
Infrared
UV
X-rays Gamma
MRI
Visual Imaging
X-ray Imaging
Electromagnetic radiation
IONIZING RADIATON MICROVAVES VISIBLE X-RAYS COSMIC
TV, RADIO
Ionizing Radiation
Radiation causes ionization of atoms and
molecules. Ionization is the underlying mechanism for most radiation detectors and also is responsible for most radiobiological effects.
Ionization
Dissociation
Somatic Effects
Acute or early (deterministic)
within days dose dependent Seen in accidents and nuclear wars Affects acutely bone marrow, GI tract and skin and less neurological system. Latent or delayed (stochastic). not seen for years cancer, cataract, shortened life span
TIME
The total radiation exposure to an
individual is directly proportional to the time he is exposed to the source. Therefore, it is wise to spend no more time than necessary near the source of radiation.
DISTANCE
The intensity of radiation from a source
varies inversely with the square of the distance.
Shielding
Lead is most commonly used to shield photons
in diagnostic imaging.
Vial Shields
560 mGy/h
1 mGy/h
2 mm lead
Radiopharmaceuticals
Pharmaceuticals are chemical compounds
that have pharmacokinetics but do not have pharmacological effects. They are usually labeled with Tc99m. For each organ there is certain radiopharmaceuticals In general, nuclear medicine images the function (physiology), not the anatomy as in conventional radiology.
Pharmaceutical
Different Phrmaceuticals
Nuclear Imaging
Not enough to detect just radioactive levels or concentrations Need device to map the radioactive distribution
External Radiation Detector
Gamma camera-cont..
Scintillation means light production. The light is converted into electrical
current which then is stored in the computer as a dot.
Crystal
Gamma Ray
10- 21 in diameter
rectangular popular
Gamma Camera
Static Image Dyamic Acquisition Images
Mobile Camera
Gamma Camera