III. MT S HP CHT THIN NHIN CHA D VNG INOLE 1.

Heteroauxin Heteroauxin c tn khoa hc l axit inol-3-ylaxetic, l cht kt tinh hnh l, tan trong cn, ete, axeton nng chy 170 oC. Heteroauxin l mt kch t thc vt, c trong hu ht cc thc vt bc cao.

CH2COOH

N H

Heteroauxin 2. Triptophan Triptophan l tn ring ca axit 2-amino-3-(inol-3-yl)propanoic, l cht kt tinh hnh l, hnh thoi hay hnh lc gic, khng mu, nng chy 289 oC km thoe s phn hy, tan trong nc nng.
H2 H C C COOH NH2 N H

Triptophan Triptophan l amino axit (-amino axit) khng th thay th trong c th ngi v ng vt, cn phi thu nhn n t thc n.

3. Scatole Scatole c tn khoa hc l 3-metylinole, l cht kt tinh khng mu, nng chy 95 oC, si 265oC, tan trong nc v cn, c mi thi. Scatole c trong nha than , cy mc nt v xc ng vt thi ra, phn ng vt do s phn hy ca triptophan trong protein.
CH3

N H

I.

Scatole Serotonin Serotonin hay enteamin, hay 5-hiroxitriptamin. Mui hiro clorua ca n l tinh th ngm nc, nng chy 167 168 oC. Serotonin l homon thn kinh v c bp, c trong v no v thnh rut. Serotonin c vai tr quan trng trong hot ng tm l v thn kinh. Nu thay i ng k nng ca n trong v no th s gy ra s ri lon tm thn.

HO

H2 H2 C C

NH2

N H

Serotonin 5. HP CHT D VNG THM 5 CNH CHA 2 HAY NHIU D T (CC AZOLE) Azole l tn gi ca cc d vng thm 5 cnh cha hai hay nhiu nguyn t, trong c t nht l mt d t nit. Tn gi km cch nh s ca chng nh sau: Cc 1,3-azole:

5
N1 H

Imidazole Cc 1,2-azole:

Thiazole

4 5
O1

3
N2

4 5
N1 H

3
N2

4 5
S1

3
N2

Isoxazole

Pirazole Cc azole cha ba, bn d t:

Isothiazole

4 5
N1 H

3
N2 5

3
N2

4
4 N 5 5

N
N

3
3
N2

N1 H

N1 N2
S 1H

Sau y chng ta ch xt 1,3- v 1,2-azole. I. CU TRC PHN T CA 1,3 V 1,2 AZOLE Nhn chung, cc azole u bn vng hn nhng kh nng phn ng li km hn cc d vng tng ng c mt d t. iu chng t rng cu trc ca cc azole gn ging vi cu trc ca cc ole (d vng thm 5 cnh 1 d t) tng ng nhng thm mt d t nit c m in cao hn cacbon lm vng azole bn vng hn ng thi hot tnh ca n b gim i.

4 5

3 2

O1