Bnh thp khp ,vim a khp thuc iu tr

Vim a khp dng thp l mt bnh kh thng gp, c bit l gii n .y l mt bnh xc nh c nguyn nhn, l do bnh nhn t sn xut ra mt cht gi l khng th c tc dng chng li cc cht to ra u khp ca chnh bn thn mnh, v th bnh c xp vo loi bnh t min dch.

Nhiu cng trnh nghin cu khoa hc gn y pht hin ra cc gen gy bnh. iu ny gii thiu tnh cht di truyn v gia nh ca cn bnh vim a khp dng thp. Vim khp dng thp l mt bnh mn tnh gy vim cc khp i xng, tn thng ph hy dn dn cc cu trc ti khp v quanh khp. Biu hin bnh gm cc triu chng: t ngt vim nhiu khp, n au ni khp vim, ha c hot dch, vim i xng cc khp nh: khp gian t bn tay, bn chn, c tay, khuu tay, c chn; cng khp ko di khong na gi lc bui sng thc dy; bin dng co cng, gp lch xng tr ngn tay, bong trt cc si gn dui, vim mng hot dch c khi gy ra hi chng rnh khi xng tay; Bnh cn c biu hin dng thp khp di da, ni tng, vim mch gy lot chn, vim thn kinh, trn dch mng phi, mng tim, vim cng mc, hi chng Sjogren l nhng triu chng khc ngoi khp. Chn on chnh xc bnh l vic kh, c khi phi sinh thit hch di da, chp Xquang... gip chn on. Cc bin php iu tr nhm trnh hoc hn ch thoi ha khp vn thng c dng l tim cc cht corticoid v khp cng ch l cc bin php tnh th ch khng gii quyt c trit .

Gn y, nh vo cc tin b v lnh vc dc hc, cc nh khoa hc pht minh ra mt phng cch iu tr mi c gi l nim hy vng cho nhng bnh nhn mc cn bnh bt tr ny. Cc nh kho cu thuc Phn khoa Thp khp thuc i hc Leeds (Anh Quc) qua qu trnh nghin cu pht hin ra rng Glucosamin c th thay i cc triu chng tn ph ca bnh vim a khp dng thp, Glucosamine l mt amino-mono-saccharide c trong mi m ca c th con ngi. Glucosamine c c th dng sn xut ra cc proteoglycan. Nhng phn t proteoglycan ny hp vi nhau thnh m sn. Ngun cung cp tng hp Glucosamine ly t glucose trong c th.Glucose Glucosamin proteoglycan sn khp.Trong cc khp b vim, lp m si ca bao khp v mng hot dch lm gim s khuch tn glucose vo m sn. Hn na hin tng vim trong khp tiu th lng glucose c gii hn ca c th. Chnh v th c s thiu ht Glucosamine.Lc ny, Glucosamine sulfate ngoi sinh l ngun cung cp tt nht cho s sinh tng hp cc proteoglycan. Ngi ta thy Glucosamine sulfate c i lc c bit vi cc m sn. N cn gip c ch cc men sinh hc nh stromelysin v collagenase gy ph hy sn khp, ngi ta thy Glucosamine sulfate ch lm tng thnh phn cc proteoglycan trong cc v tr m sn h cn phi sa cha m khng c tc dng tng t trn phn sn khp bnh thng.Trong nhiu thp nin qua, vic iu tr vim khp ch yu l dng cc thuc khng vim gim au nhm mc ch gim cc triu chng au v hn ch vn ng khp vim cho ngi bnh. Tuy nhin nhng thuc ny c rt nhiu tc dng ph v thng khng ci thin c tnh trng bnh l ca sn khp b h

hng. V vy tc dng ca nhm thuc ny ch yu ch nhm gim bt hin tng vim, ct cn au m thi. n vi nm gn y, ngi ta tm ra mt s loi thuc tng tc ln bnh l ca sn khp mt cch hiu qu, trong c Glucosamine. Thc t lm sng cho thy n mang li nhiu u im trong iu tr hn hn NSAID.u im ln nht ghi nhn c n nay l c rt t tc dng ph khi s dng Glucosamine sulfate. Mt vi trng hp d ng khng ng k i vi ngi c c a qu mn cm vi thuc.Trc y Glucosamine c xp vo nhm thuc bo v sn (gm c Glucosamine sulfate, Chondroitin sulfate v Diacerin) hay thuc tc dng tt vi cc bnh vim khp. Hin nay n c c quan Dc phm chu u (EMEA) chp nhn xt vo danh mc thuc gip ci thin cu trc trong bnh vim khp. Cc loi khc cha c chp nhn v khng p ng c cc yu cu thc nghim lm sng. c rt nhiu nghin cu th nghim so snh vi cc loi thuc khng vim khng steroid (NSAID), cho kt qu nh sau: 1. Ci thin triu chng vim khp nh au, tm khp tng ng vi NSAID trong thi gian ngn v cng vt tri hn nu ung thuc thi gian cng di. 2. Tnh an ton hn hn vi cc loi NSAID(v NSAID lun lun c rt nhiu tc dng ph km theo). 3. Ngi ta dng phi hp Glucosamine v NSAID cho kt qu tt hn khi dng n c NSAID trong thi gian ngn. Sau ngng NSAID, tip tc s

dng Glucosamine th tnh trng ci thin vn tip tc c duy tr theo kiu tuyn tnh. 4. Ngi ta thy dng NSAID, nhng ch li gim triu chng cho bnh nhn s nhanh chng mt i ngay sau khi ngng thuc. Ngc li, ngng ung Glucosamine tc dng vn tip tc ko di trong nhiu thng sau . 5. Vi nhng bnh nhn tun th phc iu tr dng Glucosamine cng di th li ch kinh t cng ln v tnh an ton v hiu qu ca n cng c pht huy