Scribd Logo
Upload

Welcome to Scribd!

  • Amyloidosis: USMLE Step 1 Web Prep - Amyloidosis

    Uploaded by

    frabzi
    5 views2 pages
    Amyloidosis is defined as the deposition of extracellular protein fibers called amyloid in tissues and organs. Amyloid is composed of fibrillar proteins with a characteristic beta-pleated sheet structure that stain pink with Congo red dye and exhibit apple-green birefringence under polarized light microscopy. There are different types of amyloidosis including primary, secondary, familial Mediterranean fever, dialysis-associated, and localized forms like Alzheimer's disease and senile cardiac amyloidosis. Clinical features include organ involvement of the kidneys, heart, liver, gastrointestinal tract, and tongue enlargement. Biopsy with Congo red staining is used for diagnosis.

    Original Description:

    wewqeq ewq2ew2qeqw2e

    Original Title

    patho 8

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    DOC, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Amyloidosis is defined as the deposition of extracellular protein fibers called amyloid in tissues and organs. Amyloid is composed of fibrillar proteins with a characteristic beta-pleated sheet structure that stain pink with Congo red dye and exhibit apple-green birefringence under polarized light microscopy. There are different types of amyloidosis including primary, secondary, familial Mediterranean fever, dialysis-associated, and localized forms like Alzheimer's disease and senile cardiac amyloidosis. Clinical features include organ involvement of the kidneys, heart, liver, gastrointestinal tract, and tongue enlargement. Biopsy with Congo red staining is used for diagnosis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    5 views2 pages

    Amyloidosis: USMLE Step 1 Web Prep - Amyloidosis

    Uploaded by

    frabzi
    Amyloidosis is defined as the deposition of extracellular protein fibers called amyloid in tissues and organs. Amyloid is composed of fibrillar proteins with a characteristic beta-pleated sheet structure that stain pink with Congo red dye and exhibit apple-green birefringence under polarized light microscopy. There are different types of amyloidosis including primary, secondary, familial Mediterranean fever, dialysis-associated, and localized forms like Alzheimer's disease and senile cardiac amyloidosis. Clinical features include organ involvement of the kidneys, heart, liver, gastrointestinal tract, and tongue enlargement. Biopsy with Congo red staining is used for diagnosis.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    USMLE Step 1 Web Prep Amyloidosis

    138150 >>> 0:00:00

    SLIDE 1 of 5

    AMYLOIDOSIS
    Definition Deposition of extracellular protein Common features -pleated sheets Micro o Amorphous pink deposits!" o #tain red $ Con%o red o Apple %reen &irefrin%ence 'ith polari(ed li%ht Composition of Am)loid *i&rillar) protein A+ component

    ,A,s
    SLIDE 2 of 5

    138155 >>> 0:01:10

    AMYLOIDOSIS CONT
    -)pes +rimar) am)loidosis A. /appa or lam&da li%ht chains +lasma cell disorders #econdar) am)loidosis AA #AA- acute phase reactant- prod &) li0er 1n%oin% inflammation 2A3 #."3 -4 5 Crohn6s
    138170 >>> 0:08:85

    SLIDE 3 of 5

    TYPES OF AMYLOIDOSIS CONT


    *amilial Mediterranean fe0er AA #AA Autosomal recessi0e 9nfection3 fe0er 5 neutrophil defect emodial)sis $associated am)loidosis A 2 M 2-micro%lo&ulin

    Carpal tunnel s)ndrome


    SLIDE 4 of 5

    138175 >>> 0:03:8:

    LOCALIZED TYPES OF AMYLOID


    Al(heimer6s disease A4 4app Chromosome 81 #enile cardiac am)loidosis 1lder men A--2 -ransth)retin
    1381;0 >>> 0:0::08

    SLIDE 5 of 5

    CLINICAL FEATURES OF AMYLOIDOSIS


    Distri&ution /idne) eart epatosplenome%al) ,9 tract -on%ue enlar%ement Dia%nosis 4iops) 3 stain 'ith Con%o red +ro%nosis +oor polari(e

    You might also like