DRUG STUDY

Generic &
Brand Name,
Classification
Dose,
Strength
&
Formulation
Indication/Mechanism
s of Drug
Action
Adverse/Side Effects
Drug Interaction
Nursing
Responsibilities
Rationale
Client
Teaching

Generic: allopurinol

Brand: Purinase

Classification:
Antigout drug


Dose: 200 mg
1tab

Frequency:
OD

Route: Oral

.


Indications:
Management of
the signs and
symptoms of
primary and
secondary gout
Management of
patients with
recurrent calcium
oxalate calculi
whose daily uric
acid excretion
exceeds 800
mg/day (males) or
750 mg/day
(females)

Therapeutic action:
Inhibits the
enzyme
responsible for
the conversion of
purines to uric
acid, thus
reducing the
production of
uric acid with a
decrease in

Adverse Reaction:
Hematologic:
Anemia, leukopenia,
agranulocytosis,
thrombocytopenia,
aplastic anemia, bone
marrow depression
CNS: Headache,
drowsiness,
peripheral
neuropathy, neuritis,
paresthesias
Dermatologic:
Rashes-
maculopapular, scaly
or exfoliative-
sometimes fatal
GI: Nausea,
vomiting, diarrhea,
abdominal pain,
gastritis,
hepatomegaly,
hyperbilirubinemia,
cholestatic jaundice
GU: Exacerbation of
gout and renal








serum and
sometimes in
urinary uric acid
levels, relieving
the signs and
symptoms of
gout.
calculi, renal failure

Interactions:
Drug-drug
Increased risk
of
hypersensitivi
ty reaction
with ACE
inhibitors
Increased
toxicity with
thiazide
diuretics
Increased risk
of rash with
ampicillin or
amoxicillin