This document summarizes the effects of abnormal proliferation of myeloid cells in hematopoiesis. It disrupts normal production of red blood cells, white blood cells, and platelets, leading to anemia, increased risk of infection and bleeding, pallor, fatigue, and shortness of breath. The abnormal cells can also spill into the bloodstream and infiltrate organs like the liver, spleen, lymph nodes and central nervous system, causing organomegaly, lymphadenopathy and increased intracranial pressure. Proliferation of these cells increases their numbers and nutritional demands, depleting the body's energy reserves and causing weight loss and generalized fatigue.
This document summarizes the effects of abnormal proliferation of myeloid cells in hematopoiesis. It disrupts normal production of red blood cells, white blood cells, and platelets, leading to anemia, increased risk of infection and bleeding, pallor, fatigue, and shortness of breath. The abnormal cells can also spill into the bloodstream and infiltrate organs like the liver, spleen, lymph nodes and central nervous system, causing organomegaly, lymphadenopathy and increased intracranial pressure. Proliferation of these cells increases their numbers and nutritional demands, depleting the body's energy reserves and causing weight loss and generalized fatigue.
This document summarizes the effects of abnormal proliferation of myeloid cells in hematopoiesis. It disrupts normal production of red blood cells, white blood cells, and platelets, leading to anemia, increased risk of infection and bleeding, pallor, fatigue, and shortness of breath. The abnormal cells can also spill into the bloodstream and infiltrate organs like the liver, spleen, lymph nodes and central nervous system, causing organomegaly, lymphadenopathy and increased intracranial pressure. Proliferation of these cells increases their numbers and nutritional demands, depleting the body's energy reserves and causing weight loss and generalized fatigue.
with normal hetopoiesis Disruption in hematopoiesis Disruption in erythropoiesis Disruption in thrombopoiesis Disruption in Leukocyte formation Decreased platelet production Increased risk for bleeding, and petechial bruising Decreased normal WBC production Increased risk for infection Pallor Low HCT Low HGB Decrease O2 circulating in the body Easy Fatigabilty Body weakness Shortness of Breath Decreased RBC production Anemia Bleeding gums
B Spillage of myeloblast in bloodstream Organ infiltration CNS Liver Spleen Lymph nodes Increased ICP Hepatomegaly Spleenomegaly Lymphadenopathy
C Increase number of myeloblasts Increase cellular demand for nutrition Depletion of bodys normal energy reserve Weight loss Generalized fatigue