08-11-14

Hemoglobin Synthesis and Catabolism

1.

1. State at least 3 laboratory abnormalities commonly associated with hemolytic anemia.

2.
3.

2. Explain the differences between intravascular and extravcular hemolysis.

3. Explain the effect of hemolysis on the level of haptoglobin.

The haptoglobin binds free hemoglobin and the complex is removed by the liver --> Haptoglobin levels
decrease when there is hemolysis.
4.
4. Name the test used to determine if an autoimmune process is the etiology of a hemolytic
anemia. Identify both names used to refer to this test.
Coomb's Test (Direct and Indirect)

5.
5. Identify the different types of direct Coombs (DAT) test positivity.
6.
6. identify at least four categories of non-autoimmune hemolytic anemia.
7.
7. List the pathways involved in normal hemolysis and recycling of hemolyzed red cells.
8.
8. Describe the findings that would be expected in each of the following organs and fluids as a
result of chronic hemolysis: sclerae, skin, gallbladder, and urine.