Professional Documents
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Lab Management Notes
Lab Management Notes
Level III: exotic agents associated w/ human disease & potential for aerosol
transmission
Biological
Spill
Hold
breath
&
leave
lab
immediately
no
enter
lab
for
at
least
30
mins
Wear
PPE
to
protect
eyes
&
mucous
membranes
decontaminate
spills
(BSL2/BSL3)
Risk
assessment
Identify
all
hazardous
materials,
consult
MSDS,
evaluate
BSL
&
type
of
toxicity
Consider
possible
route
of
exposure
Evaluate
quantitative
info
on
toxicity,
select
appropriate
procedures
to
minimize
exposure,
prepare
contingencies
Modes
of
transmission:
Airborne,
Droplets,
Contact,
Blood
borne
Prevention:
Percutaneous
Injuries:
Sharp
box
Cutaneous
Injuries:
Gloves
when
handle
blood
&
body
fluids,
wash
hands
Mucosal
exposures:
Goggles
Droplets:
Wear
N95
Airborne:
Wear
mask
(N95),
negative
pressure
room
with
doors
closed
PPE:
respiratory
equipment,
garments,
barrier
materials
protecting
rescuers
&
medical
personnel
from
exposure
to
biological,
chemical
&
radioactive
hazard
which
is
poisonous,
irritating,
corrosive,
carcinogenic
or
protect
from
hearing
loss
from
excessive
noise
levels
Other
protective
clothing:
safety
shoes,
boots,
apron,
coveralls,
full
body
suitx
Common
route
of
exposure:
inhalation,
skin
contact,
ingestion
Ergonmics:
science
of
designing
a
job,
equipment
&
workplace
to
suit
workers
needs,
with
ultimate
goals
of
making
them
safe,
comfortable
and
efficient
and
avoiding
adverse
health
effects.
DSE:
Display
screen
equipment
prolong
use
pain
and
discomfort
in
upper
limbs,
tired
eyes,
muscle
fatigue,
mental
stress
DSE
user:
work
at
computer
for
total
average
of
6
hours
/>1/3
daily
MHO:
Mind
your
back
Compressed
Gas-Cat
2
hazard:
Chemical
properties
of
gas,
Physical
hazards
Gas
cylinders:
heavy,
high
pressure,
left
standing
alone
unsupported,
damage
valve,
jet
away
like
missiles
Safety:
follow
guidelines,
secured
at
all
times
at
fixed
location,
secured
individually,
cylinder
cart
Centrifuge:
safety
cups,
disinfect
weekly
&
after
all
spills/breakage,
lubricate
O
rings
&
rotor
threads,
dont
use
rotor
that
have
been
dropped,
contact
centrifuge
rep
for
specific
information
Fire:
evacuate,
alert
others,
close
doors
to
confine
fire
&
smoke,
evacuate
through
nearest
safe
exit,
no
elevators,
move
away
from
building,
dont
return
until
all
clear
announced
Electrical
conductors:
water,
metal,
human
body
Personal
injury:
fire,
radiological
spill
Risk
management:
Top
management
set
policy,
allocate
resource;
supervisor
implement
policy,
training
workers
strict
&
rigorous
attention
to
details
of
procedures
and
practices
&
report
incidents
&
exposures
Scope
of
Accreditation:
Formal
&
precise
statement
of
the
activities
which
the
laboratory
is
accredited
for
HKAS
medical
programme
P
lab
=
directed
by
Pathologist
S
Lab
=
directed
by
Biomedical
Scientist
Lab
director
must
be
full-time
staff
HKAS
002:
Regulations
for
Lab
Accreditation
HOKLAS
015:
Technical
Criteria
for
Lab
Accreditation
`
Reference
Range
1. Select
analyte,
methodology,
instrumentation
use
for
testing.
Study
what
already
known
about
the
ISO15189
4.
Management
requirements
4.1.
Organization
&
Management
(authority,
resources,
no
pressure)
O
chart
Quality
Manager:
ensure
consistency,
quality
&
technical
validity
of
lab
results;
Maintain
quality
manual
&
operation
documentation,
monitor
lab
practice
to
verify
continuing
compliance
w/
documented
policies,
ensure
equipment
calibration
&
maintenance
done
per
schedule,
selection,
training
&
evaluation
of
internal
auditors,
schedule
&
coordination
of
internal
audits
&
management
review
4.2.
Quality
Management
System:
document
polices
&
procedures
communicated,
available,
understood
&
implemented
+
QC,
QC,
EQAP,
PT;
depends
on
size
of
lab,
staff
#,
range,
vol
of
tests
Quality
Manual:
quality
manual
describe
labs
quality
system;
shall
be
developed
as
a
working
document
for
use
by
lab
staff,
not
check
list
for
presentation
to
lab
assessors
Include
quality
policy
&
objectives,
documentation
structure,
policies,
procedures
&
roles,
scope
of
test
4.3.
Document
Control
<review
annually>
must
have
title,
date
of
issue,
page
#,
total
#
of
page,
issue
authorities,
source
identification
4.4.
Review
of
request
&
contracts
4.5.
Examination
by
referral
laboratories
4.6.
External
services
and
supplies
(verify
&
validated
before
use)
4.7.
Advisory
Services
(advice
client
on
choice
of
examination
&
interpret
results)
4.8.
Resolution
of
complaints
4.9
Identification
&
control
of
Nonconformities
e.g.
Out
QC,
complains,
calibration,
consumable
defect,
audits
4.10
Corrective
action
(investigate
to
determine
root
cause
P.A)