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Fluid and Electrolyte

balance
Willy Handoko

Body is mostly water


New planet does it have water?

Body is in osmotic
equilibrium

Check point 1
Osmosis vs osmotic pressure
Molarity vs osmolarity
Osmolarity vs osmolality
Iso, hyper and hypo osmolar

Osmolarity vs tonicity
Iso, hyper and hypo tonic

Posm = 2[Na] + [glucose]/18 +


BUN/2.8
Posm in human?

Water balance

Electrolytes in body fluids

Two carefully regulated parameters

Effective
circulating
volume
(ECV)
Plasma
volume
Extracellula
r fluid
volume

Tonicity

Serum
osmolarity
Serum Na+
concentrati
on

Check point 2
How kidney conserve water
Vasopressin and aquaporins

Plasma volume and osmolarity


osmoreceptors, baroreceptors and atrial
stretch receptor
AngII, Ald, ANP, thirst, ADH

Graphical representation of volume


vs solute in ICF and ECF

Check point 3 - IV fluid

Crystalloid vs colloid
NS 0,9%
NS 0,45%, 3%
RL
D5%
D40%
D5% - NS0,9%
D5% - NS0,45%

Thanks

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