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    Yersinia pestis is a gram-negative coccobacillus that is the causative agent of bubonic and pneumonic plague. It was discovered in 1894 by Alexandre Yersin during a plague epidemic in Hong Kong. Y. pestis typically infects rodents and is transmitted to humans by flea bites. Symptoms of bubonic plague include sudden fever, swollen lymph nodes, and general discomfort. Pneumonic plague causes respiratory symptoms like cough, chest pain, and bloody mucus. Y. pestis has been used in biological warfare by infecting fleas and releasing them from aircraft.

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    Yersinia pestis is a gram-negative coccobacillus that is the causative agent of bubonic and pneumonic plague. It was discovered in 1894 by Alexandre Yersin during a plague epidemic in Hong Kong. Y. pestis typically infects rodents and is transmitted to humans by flea bites. Symptoms of bubonic plague include sudden fever, swollen lymph nodes, and general discomfort. Pneumonic plague causes respiratory symptoms like cough, chest pain, and bloody mucus. Y. pestis has been used in biological warfare by infecting fleas and releasing them from aircraft.

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    12 views20 pages

    Y. Pestis

    Uploaded by

    Isaac Bernstein
    Yersinia pestis is a gram-negative coccobacillus that is the causative agent of bubonic and pneumonic plague. It was discovered in 1894 by Alexandre Yersin during a plague epidemic in Hong Kong. Y. pestis typically infects rodents and is transmitted to humans by flea bites. Symptoms of bubonic plague include sudden fever, swollen lymph nodes, and general discomfort. Pneumonic plague causes respiratory symptoms like cough, chest pain, and bloody mucus. Y. pestis has been used in biological warfare by infecting fleas and releasing them from aircraft.

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    YERSINIA PESTIS

    Formerly Pasteurella pestis

    What is Yersinia pestis

    GOOD QUESTION!

    This

    End of slideshow, click to exit

    It is
    Gram negative
    Coccobacillus
    Obligate intracellular pathogen
    Fermentative
    A facultative anaerobe
    Non-motile inside of host but motile when isolated. (different!)

    NOT SO INTERESTING BUT


    FUNDATORY HISTORY

    Yersinia pestis was


    discovered in Hong Kong in
    1894 by a Swiss physician
    Alexandre Yersin during the
    Chinese epidemic of plague!

    Y. Pestis interacts with


    mostly rodents and fleas.
    This is how it is able to invade
    humans and create

    Y.
    Pestis
    inside
    flea

    Diseases

    Bubonic Plague
    Pneumonic Plague

    Symptoms of Bubonic PLague


    Sudden high fever
    Swelling of lymph glands
    Chills
    General Discomfort
    Muscular pain
    Headaches
    Seizures

    SYMPTOMS OF Pneumonic
    Plague
    Trouble Breathing
    Chest pain
    Cough
    Fever
    Headache
    General Weakness
    Bloody saliva and
    mucus

    Y.
    Pesits

    INFECTION CYCLE

    Resevoi
    r

    Techinall
    y True, if
    Direct
    you eat
    Contact
    mice.

    Vector

    Flea feeding
    off blood

    Blood meal

    Victim

    IN ITS PNEUMONIC FORM,


    Human human transmission

    HEALTHY
    MAN

    INFECTE
    D MAN

    Cough/sneeze

    BUBONIC PLAGUE

    Exit (highly
    contagious)

    Disease

    Spread
    (Lymphatic
    & systemic)

    Entry
    (inflected
    flea bite)

    PNEUMONIC PLAGUE

    Fun overview

    Entry
    (airborne)

    Exit
    (airborne)

    Disease

    HOW TO NOT GET INFECTED


    Dont touch dead rodents
    Dont eat/roll around in live rodents
    COOK your meat correctly
    Use bug repellent for fleas with DEET or permethrin
    Treat pets for fleas
    Wear long sleeves
    Give money to vaccine researchers BECAUSE THERE ISNT a
    vaccine YET
    Avoid the sick

    BIOLOGICAL WARFARE
    1347- Plague victims catapulted by
    mongols.

    1940- Japanese plane releasing rice


    and rat fleas containing Y. pestis

    You guys didnt


    read the article

    Mutant
    No
    Protease

    Wild Type

    Protease

    Fas-FasL
    Signalli
    ng

    Caspase-3

    WORKS CITED

    Caulfield, A., Walker, M., Gielda, L., Lathem, W. (2014) The Pla
    Protease ofYersinia pestisDegrades Fas Ligand to Manipulate
    Host Cell Death and Inflammation. Cell Host and Microbe 15(4)
    (424-434)
    "Plague."Centers for Disease Control and Prevention. Centers for
    Disease Control and Prevention, 28 Nov. 2012. Web. 14 July 2014.

    ANY
    QUESTIO

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