Histologi of

The Immune System

E. A. JALAL

The Lymphoid
Organs
Central/Primary lymphoid
organs
Bone marrow
Thymus

Peripheral/Secondary lymphoid
organs
Lymph nodes
Spleen
Mucosa-associated lymphoid
tissue (MALT)
Gut-associated lymphoid
tissue (GALT)
Nasal-associated lymphoid
tissue (NALT)
Bronchus-associated
lymphoid tissue (BALT)
Urogenital tract and other
mucosa

Bone Marrow

Thymus
Cortex

Medulla

Hassal corpuscle

Thymus

T cells development in thymus

 CD8+, CD3+ TCR

Nave Cytotoxic T Cells

Thymus derived
lymphocytes
( T Lymphocytes)

CD4+, CD3+ TCR

Nave Helper T Cells
CD4+, CD25+, FOXP3+
Regulatory T Cells
CD4+, TCR NK T /
Natural Killer T Cells
CD3+, TCR
T Cells

Lymphocytes mature in the

bone marrow or the
thymus,
then congregate in
lymphoid tissue throughout
the body

 The lymph nodes

filter out antigens
draining from the
peripheral bodily
tissues.

A lymph node
Capsula fibrosa

Cortex
Para cortex

Hylus

Medulla

Figure 1-8 part 1 of 2

Lymphonodules

Germinal center

Afferen lymph vessel

Sinus sub capsularis

Sinus trabecularis

High Epithelial Venule

Medullary cords and sinuses

Spleen

Spleen

Spleen. Trabecula, central artery,

splenic corpuscle

White pulp

Red pulp

Red pulp

Reticular fiber, spleen

The Mucosal Immune System

Mucosa-associated lymphoid
tissues

MALTs

GALTs

Peyers patch

M cells

Lymphocytes in Lamina Propria

Waldeyers
ring

Tonsila palatina

Tonsila lingualis

Tonsila
pharingea

Bronchus-associated LT

Solitary lymph node, upper resp

tract

Mucosal Immune System

IELs
Intra Epithelial
Lymphocytes

LP
Lamina Propria
Lymphocytes

ILF
Isolated Lymphoid
Follicles

PP
Peyers Patches

MLN
Mesenteric Lymph
Nodes

Mucosal Immune System