HISTOLOGI

SISTEM IMUN

E. A. JALAL
LIMFOSIT DAN ORGAN LIMFOID
LYMPHOCYTE AND LYMPHOID ORGANS
The Lymphoid Organs

Central/Primary lymphoid organs

Bone marrow
Thymus

Peripheral/Secondary lymphoid
organs

Lymph nodes
Spleen
Mucosa-associated lymphoid tissue
(MALT)

Gut-associated lymphoid tissue

(GALT)
Nasal-associated lymphoid
tissue (NALT)
Bronchus-associated lymphoid
tissue (BALT)
Urogenital tract and other
mucosa
 LIMFOSIT

 Limfosit dibentuk
didalam sumsum tulang
 Dari sel induk limfosit
(progenitor) dihasilkan 3
macam sel:
 Limfosit B (B cell)
 Limfosit T (T cell)
 Sel NK (natural killer cell)
 Secara morfologis
identik, dibedakan
dengan mengenali
molekul protein pada
permukaan sel (marker)
Bone Marrow
 Thymus

Cortex

Medulla

Hassal corpuscle
Thymus
T cells development in thymus
  CD8+, CD3+ αβ TCR Naïve
Cytotoxic T Cells
Thymus derived
lymphocytes  CD4+, CD3+ αβ TCR Naïve
( T Lymphocytes) Helper T Cells

 CD4+, CD25+, FOXP3+

Regulatory T Cells

 CD4+, αβ TCR NK T /
Natural Killer T Cells

 CD3+, γδ TCR
γδT Cells
Lymphocytes mature in the bone
marrow or the thymus,
then congregate in lymphoid
tissue throughout the body
• The lymph nodes
filter out antigens
draining from the
peripheral bodily
tissues.
A lymph node

Capsula fibrosa

Cortex

Para cortex

Medulla
Hylus
Figure 1-8 part 1 of 2
Lymphonodules Germinal center
Afferen lymph vessel
 Sinus sub capsularis

Sinus trabecularis
High Epithelial Venule

Medullary cords and sinuses

Spleen
Spleen
Spleen. Trabecula, central
artery, splenic corpuscle
White pulp
Red pulp
Red pulp
Reticular fiber, spleen
The Mucosal Immune System
MALTs
MUCOSA-ASSOCIATED LYMPHOID
TISSUES
GALTs
Peyer’s patch
M cells
Lymphocytes in Lamina
Propria
Waldeyer’s
ring
Tonsila palatina
Tonsila lingualis
Tonsila
pharingea
Bronchus-associated LT
Solitary lymph node, upper resp tract
Mucosal Immune System

 IELs
 Intra Epithelial
Lymphocytes
 LP
 Lamina Propria
Lymphocytes
 ILF
 Isolated Lymphoid
Follicles
 PP
 Peyer’s Patches
 MLN
 Mesenteric Lymph
Nodes
Mucosal Immune System