Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility

(Brand Name) Route, Action

Frequency
Methylergonovine Indication: 2 Ampules Methergine Cardiovascular: > contraindicated in >Be alert for adverse
maleate Prevention and immediately ↓ hypertension, patients reactions and drug
(Methergine, treatment of after the Stimulates uterine temporary chest hypersensitive to interactions.
Methylergobasine postpartum and delivery of smooth muscles pain, palpitation methylergonovine or
Methylergobrevin postabortion the Placenta ↓ any component of the >This drug should be
Methylergonovine) hemorrhage producing CNS:Hallucinations, formulation. used extremely
caused by uterine sustained dizziness, seizure, carefully because of it's
atony or contractions headache >ergot alkaloids are potent vasoconstrictor
subinvolution ↓ contraindicated with action. I.V. use may
thereby shortens Gastrointestinal: potent inhibitors of induce sudden
the third stage of Nausea, vomiting, CYP3A4 (includes hypertension and
labor diarrhea, foul taste protease inhibitors, cerebrovascular
azole antifungals, and accidents. As a last
Local: some macrolide resort, give I.V. slowly
Thrombophlebitis antibiotics); over several minutes
and monitor blood
Otic: Tinnitus >hypertension; pressure closely.
toxemia of pregnancy
Renal: Hematuria (PIH) >Monitor Uterine
Contractions
Respiratory:
Dyspnea, nasal
congestion

Miscellaneous:
Diaphoresis

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Oxytocin Indication: For Oxytocin Cardiovascular: > Contraindicated in > Monitor and record
(Pictopin, Induction of labor stimulation of ↓ hypertension; patients hypersensitive uterine contractions, heart
labor: 10 units rate, BP, intrauterine
Syntocinon) at term; control of (1ml) of drug
Causes potent and increased heart rate, to the drug or any of
postpartum selective systemic venous its component. pressure, fetal heart rate,
infused in 1L
and blood loss q15.
bleeding; D5LRS before stimulation of return, and cardiac
adjunctive deliver uterine and output, and > Also contraindicated
>Be alert for adverse
therapy in mammary gland arrhytmias in cephalopelvic
For reaction
management of smooth muscles disproportion or
Reduction of
abortion Postpartum ↓ CNS: seizures, delivery that requires >Monitor I/O. Antidiuretic
bleeding: 1 producing sustained coma from water conversion, as in effect may lead to fluid
amp after contractions intoxication tranverse lie; in fetal overload, seizures, and
delivery of ↓ distress when delivery coma
placenta isn’t imminent; in
Induces labor and Gastrointestinal:
milk ejection and prematurity and in >never give oxytocin
Nausea, vomiting,
severe toxemia, simultaneously by more
reduces post partum
than one route.
bleeding GU: titanic uterine hypertonic uterine
contractions, patterns, total placenta >have 20% solution
abruption previa or vasa previa. magnesium sulfate
placentae, impaired available for relaxation of
uterine blood flow, the myometrium.
pelvic hematoma
> Also contraindicated >If contractions are less
in fetal distress. than 2 minutes apart, if
Hematologic:
they’re above 50mm Hg
afibrinogenemia
,or if they last 90seconds
or longer, stop infusion,
Respiratory: and turn patient on her
anoxia, asphyxia side, and notify physician
or midwife.

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Hyoscine Indication: Given via Hyoscine CNS: dizziness, Contraindicated in >Be alert for adverse
Butylbromide To reduce IV, 1mg/ml Butylbromide headache, patients with angle- reactions and drug
(Buscopan) secretions to promote ↓ restlessness, closure glaucoma, interactions.
perioperatively. cervical Inhibits muscarinic disorientation, obstructive uropathy,
effacement. actions of irritability, fever asthma, COPD, >Encourage pt. to void
acetylcholine in the myasthenia gravis,
ANS GI: constipation, paralytic ileus, >Monitor BP for
↓ dry mouth, nausea, intestinal atony, & possible hypotension.
Affecting neural vomiting unstable CV.
pathway >Monitor cervical
↓ CV: palpitations, effacement and
Relieves spasticity, tachycardia, dilatation.
nausea and flushing
vomitting; reduces
secretions; and EENT: dilated
blocks cardiac pupils, blurred
vagal reflexes. vision,
photophobia,
↓ dysphagia
Promotes cervical GU: urinary
effacement hesitancy, urinary
retention

Skin: rash, dryness

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Hydralazine Indication: 5 mg/dose Hydralazine CNS: peripheral Contraindicated to pt.s >Assess blood pressure
(Apresoline) Pre-eclampsia / then 5-10 ↓ neuritis, headache, hypersensitive to the before starting therapy
eclampsia mg every Directly relaxes dizziness drug and any of its and regularly thereafter.
20-30 arteriolar smooth component and in
minutes as muscle CV: orthostatic those with coronary >Instruct client to take
needed. ↓ hypotension, artery disease or mitral oral form with meals.
Vasodilaion tachycardia, valvular rheumatic
↓ arrythmias, angina, heart disease. >Inform client that
Lowers Blood palpitations. orthostatic hypotension
Pressure Use cautiously in can be minimized by
GI: n/v, diarrhea, patients with rising slowly and not
anorexia suspected cardiac changing position
disease, CVA, or suddenly.
Hematologic: severe renal
neutropenia, impairment, and in >Tell pt. not to abruptly
leukopenia, those taking other stop taking drug, but to
agranulocytopenia antihytensives. call prescriber if adverse
reaction occurs.
Metabolic: weight
gain, sodium >Tell client to limit
retention sodium intake.

Skin: rash

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Hydralazine Indication: 5 mg/dose Hydralazine CNS: peripheral Contraindicated to >Assess blood pressure
(Apresoline) Pre-eclampsia / then 5-10 ↓ neuritis, headache, patients who are before starting therapy
eclampsia mg every Directly relaxes dizziness hypersensitive to the and regularly thereafter.
20-30 arteriolar smooth drug and any of its
minutes as muscle CV: orthostatic component and in >Instruct client to take
needed. ↓ hypotension, those with coronary oral form with meals.
Vasodilaion tachycardia, artery disease or mitral
↓ arrythmias, angina, valvular rheumatic >Inform client that
Lowers Blood palpitations. heart disease. orthostatic hypotension
Pressure can be minimized by
GI: n/v, diarrhea, Use cautiously in rising slowly and not
anorexia patients with changing position
suspected cardiac suddenly.
Hematologic: disease, CVA, or
neutropenia, severe renal
leukopenia, impairment, and in
agranulocytopenia those taking other
antihytensives.
Metabolic: weight
gain, sodium
retention

Skin: rash

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Phytomenadione >To stimulate the 0.1 cc via Sterility of GI tract >The synthetic >Contraindicated to >Ensure that the
(Vitamin K, clotting factors of IM to the ↓ form of Vitamin K those who are adequate dose is given
Phylloquinone, the newborn Vastus Administration of and Vitamin K3 hypersensitive to any while following the
menaquinone) >To prevent Lateralis of Vitamin K (Menadione) can component of Vitamin proper IM Drug
hemorrhagic the newborn ↓ cause allergic K containing products. Administration.
disease of the Increased Synthesis reaction, Hemolytic
Newborn. of precursor Anemia, and >Apply pressure to the
proteins in the GIT Cytotoxicity in injection site to prevent
mainly factors II, liver cells. further bleeding.
VII, IX, and X are
produced and >Document the giving
increased. of the medication to
↓ newborn to prevent an
From 30-60% accidental doubling of
compared to adult the dose.
clotting factor
values, blood
clotting factors
increase.

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Oxytetracycline To prevent 1 cm strip >Irritation
(Terramycin infection of the applied >Redness
Opthalmic eye which may from the >Tearing
Ointment, derive from flora inner >Iching sensation
Terak, or present canthus of
Terramycin infections of the the eye to
with vagina during the outer
Polymyxin B) normal canthus
spontaneous
delivery

To prevent
Opthalmia
neonatorum in
infants.

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Nubaine

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Lidocaine >Injected prior to For normal Lidocaine > Dizziness >Hypovolemia > Observe for untoward
(Xylocaine) normal vaginal ↓ >Paresthesia >Heartblock reactions such as
spontaneous delivery: Stabilizes the >Drowsiness >Other Conduction drowsiness, depressed
delivery to 50mg/ml of neuronal membrane >Confusion Disturbances respiration, or seizures.
anesthetize the a 5% ↓ >Respiratory
area of the hyperbaric Inhibits sodium ion Depression
perineum to be solution or movemnts >Convulsions
used for 9mg-15mg ↓
episiotomy. (0.6ml-1ml) Conduction of
of a 1.5% impulses are
>Used as a local solution. inhibited
anesthesia for ↓
Cesarean section. Local loss of pain
For sensation
Cesarean
Section:
Up to 75 mg
(1.5ml) of a
5%
hyperbaric
solution.

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Duvadilan

Maniulit, Joeanne Mae A.

N-304 Group 3
Generic Name Indication Dosage, Mechanism of Adverse Reaction Contraindication Nursing Responsibility
(Brand Name) Route, Action
Frequency
Epinephrine

Maniulit, Joeanne Mae A.

N-304 Group 3
Maniulit, Joeanne Mae A.
N-304 Group 3