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histolec2-Connective tissue

histolec2-Connective tissue

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lecture~ connective tissue~
lecture~ connective tissue~

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Published by: Laine Aerith Sylvire Yue on Sep 04, 2008
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05/09/2014

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CON NECT IV E TIS SUE

Components
1. Cellular component a. fibroblast b. fat cells c. white blood cell derivatives 2. Fibrous component – collagen, elastin, reticular 3. Ground substance

Fibroblast
- most common cell - Single,spindle shaped , elongated - Secretes : fibrous component ground substance

Fibers
• Collagen fibers - most abundant protein in human body - fibrillar proteins secreted by fibroblast - amino acids : glycine, proline, hydroxyproline - protein unit: tropocollagen

Reticular fibers
- Thinnest - Network of fibers - Argyrophilic fibers - Type III collagen - Location: smooth muscle , endoneurium hematopoetic organs parenchymal organs

Elastic fibers
- 3 types of fibers: oxytalan, elaunin, elastin - Location: smooth muscle cells walls of large arteries

Ground Substance
• Composition : a. glycoproteins – fibronectin, laminin, chondronectin b. proteoglycans – core protein + GAG

Glycosaminoglycans
• 4 groups: a. hyaluronic acid b. heparin and heparan sulfate c. chondroitin sulfate dermatan sulfate d. keratan sulfate

PROTEOGLYCAN STRUCTURE & H2O-BINDING Sugar side-chains of repeating pairs (disaccharides)

H2O
SO4 SO4

Core protein Side chains bear

-XL-GA-GU-GA-GU-GA-GU-GA-GUco o
H2O -binding

charged groups

which mutually repel, but cannot disperse because of O2 bonds & anchorage to the core protein

}

SO4

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