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  • Mechanism of Muscle Contraction

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    Rocking Ripun
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    The document summarizes the mechanism of muscle contraction at the molecular level. It describes how an action potential travels down the sarcolemma and T-tubules to the sarcoplasmic reticulum, causing calcium ions to be released. The calcium ions bind to troponin C, causing tropomyosin to move and expose actin binding sites for myosin heads. The myosin heads then bind to actin and generate a power stroke through ATP hydrolysis, causing sliding of the actin and shortening of the sarcomere. When calcium ions are reabsorbed by the sarcoplasmic reticulum, relaxation occurs as tropomyosin again covers the actin binding sites.

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    The document summarizes the mechanism of muscle contraction at the molecular level. It describes how an action potential travels down the sarcolemma and T-tubules to the sarcoplasmic reticulum, causing calcium ions to be released. The calcium ions bind to troponin C, causing tropomyosin to move and expose actin binding sites for myosin heads. The myosin heads then bind to actin and generate a power stroke through ATP hydrolysis, causing sliding of the actin and shortening of the sarcomere. When calcium ions are reabsorbed by the sarcoplasmic reticulum, relaxation occurs as tropomyosin again covers the actin binding sites.

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    26 views10 pages

    Mechanism of Muscle Contraction

    Uploaded by

    Rocking Ripun
    The document summarizes the mechanism of muscle contraction at the molecular level. It describes how an action potential travels down the sarcolemma and T-tubules to the sarcoplasmic reticulum, causing calcium ions to be released. The calcium ions bind to troponin C, causing tropomyosin to move and expose actin binding sites for myosin heads. The myosin heads then bind to actin and generate a power stroke through ATP hydrolysis, causing sliding of the actin and shortening of the sarcomere. When calcium ions are reabsorbed by the sarcoplasmic reticulum, relaxation occurs as tropomyosin again covers the actin binding sites.

    Copyright:

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    of 10

    Mechanism of muscle

    contraction

    SUBMITTED TO- Dr.Deeptee warikoo


    MADE BY- Ripun BPT 4th yr.
    H zone
    TROPOMYOSIN
    ACTIN
    SARCOTUBULAR
    MYOSIN SYSTEM
    HEAD MYOSIN
    SARCOPLASM

    A-BAND I-BAND

    SARCOMERE
    GENERAL INTRODUCTION

     Originally proposed by Huxley


     At that time it was known as SLIDING
    FILAMENT THEORY
     Now it is known as CROSS BRIDGE THORY or
    RATCHET THEORY
    Mechanism
    Mechanism at molecular level-
    •Boat,bars and oars
    •Cross bridges formation
    •Attachment swivelling detachment cross bridge
    cycle
    • power stroke
    •Type of contraction
    Role of Troponin, Tropomyosin & Calcium
    ions
    Summarized Mechanism-
    On the sarcolemma an action potential (AP)
    develops

    Action potential proceeds downwards the


    sarcolemmal membrane

    AP enters within the muscle cell via T-tubule


    AP comes in contact with the cisterns

    Released Calcium ions binds with the


    Troponin-c which results in loosening
    of the tie between Troponin & Actin

    It causes Tropomyosin filament to move


    away
    Myosin head now gets attached to
    these uncovered sites

    Power stroke develops

    Sliding of Actin

    Shortening of sarcomere
    CONTRACTION DEVELOPS

    The released calcium ions now return to


    the cistern

    Relaxation develops
    Rigor mortis
    Treppe-staircase phenomenon,many
    curves are formed each having a higher
    stimulus than previous one.
    Clonus-if repeated stimulus is given
    during contraction
    Tetanus-streamlined curve is produced
    bcz repeated stimulus is given during latent
    period.
    Twitch-a single muscle will produce a
    single muscle curve
    Thank
    thank you
    you

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