Predisposing Factor: Family history of cancer

Precipitating Factors: Exposure to pesticides Exposure to UV light (living in mountain province)

Human cells releases growth factor Normally bind to adjacent cells Cells travel to nucleus

Activates proto oncogenes Error occur in mitosis

Mutation occurs in one gene

Proto oncogenes becomes oncogenes

Gene malfunction

Cell grow and divide repeatedly Excretes growth inhibitor Nucleus activates TSG P53 prevents prevent cell from reproducing until repair TSG malfunction P53 allows cell to continue in reproduction Unable to repair apoptosis Produces telomerase Extends length of telomerase DNA damage

Never ending cell division Mass/tumor

Abnormal tissue formation