DRUG NAME

MECHANISM OF ACTION

INDICATION SIDE EFFECTS CONTRAININDICATION

NURSING RESPONSIBILITIES

BRAND NAME: Alloprim GENERIC NAME: allopurinol CLASSIFICATION: antigout DOSAGE: 200mg/m2/day ROUTE: IV

inhibits the enzyme responsible for the conversion of purines to uric acid, thus reducing the production of uric acid with a decrease in serum and sometimes in urinary uric acid levels, rekieving the signs and symptoms of gout.

Allopurinol also is used to prevent elevation of blood uric acid in patients undergoing chemotherapy for the treatment of certain cancers and in patients with recurrent calcium kidney stones and elevated uric acid levels.

y diarrhea y nausea y rash and itching y Drowsiness

y y y y y

liver disease kidney disease diabetes hypertension unusual diets (e.g., fasting) blood dyscrasias allergy to allopurinol

y y

y y

y painful urination y blood in the urine y eye irritation y y

y y swelling of the mouth or lips

administer drug following meals encourage patient to drink 2.5 to 3L/day to decrease the risk of renal stone development check urine alkalinity discontinue drug at first sign of skin rash; severe to fatal skin reactions have occurred. arrange for regular medical follow-up and blood tests.