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REVIEW
Occipital Neuralgia:
Anatomic Considerations
ALPER CESMEBASI,1,2 MITCHEL A. MUHLEMAN,2,3 PAUL HULSBERG,2 JERZY GIELECKI,4
PETRU MATUSZ,5 R. SHANE TUBBS,2,6 AND MARIOS LOUKAS2,4*
1
INTRODUCTION
First described in 1821 by J. Beruto y Lentijo and
M.M. Ramos, occipital neuralgia can be a debilitating
disorder characterized by recurrent headaches localized in the occipital region (Perelson, 1947). The
symptoms of occipital neuralgia are often described as
paroxysmal burning, aching pain in the distribution of
the greater, lesser or third occipital nerves (Graff-Radford et al., 1986; Horowitz and Yonas, 1993; Sulfaro
and Gobetti, 1995). The International Headache Society (2013) denes these headaches as consisting of
paroxysms of jabbing pain in the distribution of the
greater, lesser, or third occipital nerves.
Of the 180 types of headache recognized by the
International Headache Society, occipital neuralgia is
classied as a subset including post traumatic pain,
whiplash, cervical spine abnormality, tension head-
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Reporting authors
Various authors
Occipital Neuralgia
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Fig. 2. Drawing of the nerves of the occiput. Surrounding images depict potential compression sites of
these nerves along their course. 1: Origin of the third
occipital nerve and proximal connection with the greater
occipital nerve. 2: Greater occipital nerve as it courses
inferior to the inferior oblique muscle. 3: Greater occipital
nerve coursing through the semispinalis capitis muscle.
4: Greater occipital nerve exiting the aponeurosis of the
trapezius muscle. 5: Greater occipital nerve traveling
before innervating and piercing the semispinalis capitis muscle (Standring, 2008). The GON then pierces
the tendon of the trapezius muscle along with the
deep cervical fascia just below the superior nuchal line
of the occipital bone (Schaeffer, 1953). While traversing the supercial fascia along with the occipital
artery, the GON splits into many terminal branches
that connect with the third and lesser occipital nerves
to supply the skin of the scalp as far forward as the
coronal suture (Schaeffer, 1953; Standring, 2008).
Tubbs et al. (2007) found that the GON pierced the
semispinalis capitis muscle on average 2 cm superior
to the intermastoid line. The mean diameter of this
nerve was 3.5 mm and it was found to branch into
medial and lateral branches on average 0.5 cm superior to the inion.
Emerging from the C2 dorsal ramus. With such
a meandering path through the posterior head and
neck, it is not surprising that the GON is at high risk
for compression and entrapment. The rst area where
the GON may be irritated is just as the nerve emerges
from the C2 dorsal ramus between the atlas and the
axis (Hunter and Mayeld, 1949; Steechison and Mullin, 1994; Loukas et al., 2006; Hoppenfeld, 2012).
Hunter and Mayeld (1949) have described the anatomical basis for this compression, particularly when
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Occipital Neuralgia
above the mastoid process to supply the skin of the
scalp along with the GON (Schaeffer, 1953). Tubbs
et al. (2007) found that the LON branched into a
medial and lateral component at approximately the
midpoint between a horizontal line drawn through the
inion and the intermastoid line. The main LON trunk
was found on average 7 cm lateral to the inion.
Stretching of the LON by the inferior oblique
muscle. Compared with the vast amount of studies
on the contributions of the GON to occipital neuralgia,
there is a somewhat limited amount of literature concerning the anatomical etiology of lesser occipital neuralgia. Lucas et al. (1994) published a comprehensive
review concerning the LON and the etiology of cervicogenic headaches. They described the details of the
C2 ventral ramus, noting that either the levator scapulae or the middle scalene can be encircled anteriorly
by one of the loops of this nerve (Lucas et al., 1994).
When forceful movements are made, the inferior
oblique muscle can stretch the C2 ventral ramus,
which can result in neuralgia of the LON (Lucas et al.,
1994).
Crossing the atlantoaxial junction. Another
point of compression for the C2 ventral ramus is present as the nerve crosses the lateral atlantoaxial articulation on the posterosuperior articular process of the
axis, rather than the facet of the axis (Lucas et al.,
1994). Hunter and Mayeld (1949) described this site
in their discussion of rotary movements of the head.
While the dorsal ramus (GON) is compressed at the
point where the atlantal facet strikes the lamina of the
axis, the ventral ramus is also at risk because of the
increased distance that the nerve must traverse in
order to leave the spine. When a force is applied in
this position, a stretch injury of the LON may occur
(Hunter and Mayeld, 1949).
Compression by the vertebral artery. The proximity of the C2 ventral ramus to the vertebral artery
can lead to a form of vascular compression, particularly when the nerve crosses the posterolateral surface of the artery (Lucas et al., 1994). The path of the
ventral ramus is known to express anatomical variations as Bogduk (1981) stated that the nerve crosses
anteriorly to the vessel, while Lucas et al. (1994)
were only able to nd one example of this aberration
in 16 dissections.
Clinical features of LON compression. Neuralgia
of the LON can sometimes be confused with that of
the GON, leading to an under-representation of LON
neuralgia in the literature. Sjaastad et al. (1983), in a
hypothesis of cervicogenic headaches, stated that
anesthetic blockade of the GON stopped the pain of
occipital neuralgia and led to sensory decit in the
area above and behind the ear. According to the anatomical study performed by Lucas et al. (1994), this
area is actually innervated by the LON rather than the
GON. The authors of the latter study suggest that
Sjaastad et al. (1983) were actually treating lesser
occipital neuralgia, most likely in conjunction with that
of the GON due to their overlap in cutaneous distribution (Lucas et al., 1994).
In another study on cervicogenic headaches, Fredriksen et al. (1987) reported the clinical manifestations of 11 patients. Ten of these patients experienced
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it is Valsalva-induced. Rapoport et al. (1999) presented two similar cases, each representing one of
the conditions in present discussion, and discussed
the similarities and distinctive presentations of each.
The most commonly presenting symptom of the
Chiari I malformation is headache, head pain, and
pressure in the occipital region (Cesmebasi et al.,
2014). If a patients occipital pain is worsened by
coughing, yawning, or Valsalva maneuvers, this is typically indicative of Chiari I malformation. Such maneuvers may result in descent of the herniated cerebellar
tonsils with subsequent intradural irritation of the
upper cervical nerve roots and thus radiating pain in
the distribution of the occipital nerves.
CONCLUSIONS
ACKNOWLEDGMENTS
The authors thank the individuals who donated their
bodies to the Department of Anatomy. This article was
made possible by the seless gift from donor cadaver
patients.
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