Physical Pharmacy II

PHR 210
Course Outline
Course Faculty: D M ISHA OLIVE KHAN
Email: isha.khan@northsouth.edu
Available at: SAC 955

Course Content & Distribution

Diffusion and Dissolution (2 classes)
Surface and interfacial phenomena (3)
Micromeritics (3)
Colloidal dispersions (3)
Chemical thermodynamics (5-6 classes)
Phase Equilibria (4)
Pre-formulation studies (2)

Course Contents
Diffusion and Dissolution: Ficks law of diffusion, drug release from
modern drug delivery systems.
Surface and interfacial phenomena: adsorption at liquid surfaces,
classification of surfactants, HLB system, critical micelle
concentration, application of surface active agents
Micromeritics: Introduction and concepts of particle size
determination, different means of expressing particle size, methods of
particle size determination, powder properties.
Colloidal dispersions: Types of colloidal dispersions, preparations,
properties and purification of colloids, pharmaceutical applications of
colloids.
Chemical thermodynamics: Introduction, scope and limitations, types
of thermodynamic systems and processes, First law of
thermodynamics, enthalpy, heat capacities, thermochemistry,
thermochemical laws, 2nd law of thermodynamics, entropy.
Phase Equilibria: Phase rule, phase conversions, freeze drying.
Pre-formulation studies: physical and chemical incompatibilities.

Recommended Books:
1. Physical Pharmacy: Alfred Martin.
2. Aultons Pharmaceutics

3. Essentials of Physical Pharmacy: B.S. Bahl, G.D. Tuli, Arun

Bahl.