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Neuro Study Guide
Neuro Study Guide
Neurotransmitters:
1. Chemicals that cross synaptic cleft
a. dopamine
b. serotonin
c. norepinephrine
d. GABA
e. Enkephalin, endorphin
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Anatomy of Brain:
1. Cerebrum: higher thought, two hemispheres
a. Corpus callosum: nerve fibers that connect the two hemispheres
b. four lobes:
Frontal: concentration, abstract thought, motor function
Parietal: sensory, pain, touch, temperature
Temporal: auditory, sensory and speech
Occipital: visual
2. Brain Stem:
a. midbrain: relay station
b. pons: respirations
c. medulla: HR, respirations, blood vessel diameter, sneezing, swallowing, vomiting
3. cerebellum: motor function, balance
4. basal ganglia,: asssits cerbral cortex in smooth voluntary movement
5. thalamus: emotions, relay station to other areas of body
6. hypothalamus: regulations of body temp, sleep wake- cycles ect, considered master gland
Spinal cord: carries messages from brain to rest of body, 1st cervical to 2nd lumbar vertebra
Afferent fibers: sensory
Efferent: motor
Cerebral circulation:
1. Arteries: 2 internal carotid, 2 vertebral
2. Veins: do not have valves
Diagnostic Tests:
Skull and spinal x ray: bone information such as fractures, dislocation, compressions ect.
a. maintaining immobilzation is important when dealing with these injuries!!
CT: can be with or without dye,
a. detects intracranial bleeding, cerebral edema, infarctions, hydrocephalus, shifts of brain
structures
b. pre procedure: need informed consent if using dye!
c. monitor for allergies for shellfish, iodine (if using dye)
d. hold metformin (if using dye) to limit renal damage, need current BUN and creatinine
MRI: Ids tumors and vascular abnormalities, similar to CT but does not need dye
a. no metal
b. no MRIs on pacemakers ect.
c. claustrophobia an issue
Lumbar puncture:
a. insertion through L3 - L4
b. used to take sample of CSF
c. contraindicated with clients with increased intracranial pressure
d. empty bladder before
e. knee chest position during procedure
f. complication is headache due to loss of CSF, must call physician
Meylogram: injection of dye or air into subarachnoid space to detect abnormalities of spinal cord and
vertebrae, (not used as much due to the use of CT and MRI) ..true dat.
a. #1 complication is headache due to loss of CSF similar to lumbar puncture
Cerebral Angiography: perfusion study, such as aneurisms
EEG: graphic recording of electrical activity
a. need to hold stimulants, anticonvulsants, antidepressants ect before procedure
Neurological Assessment:
1. Subjective data: loss of consciousness, dizziness, fainting, numbness, ect., H/A, convulsions
2. mental status
a. observation of patient
b. asking questions
c. objective data: posture, gait, motor movements, dress, hygiene, facial expressions
d. mood, thought process, level of consciousness
e. length of concentration
f. memory
g. abstract reasoning, sound judgments ect.
3. Cranial Nerves:
I Olfactory: hold scent under nostril
II Optic: eye chart
III Oculomotor: follow finger, eye movement
IV Trochlear: eye movement
V Trigeminal: sensory function, light versus sharp touch
VI Abducens: eye movement
VII Facial: sensory and motor function of face,
VIII Acoustic: whisper test
IX Glossopharyngeal: say ah
X Vagus
XI Spinal acessory: shrug shoulders
XII Hypoglossal: protude tongue.
4. Cerebellar function
5. Motor assessment: muscle size, tone, movement ect.
6. reflexes
Glasgow coma: score between 1 - 15. score of 8 coma is present (probably needs intubation)
a. eye opening
b. verbal
c. best motor response
Respirations:
Cheyne-Stokes: periods of apnea
Neurogenic hyperventilation: rapid and deep sustaining respirations, dysfunction of midbrain and middle
pons
Apneustic: irregular respirations with pauses at end of inspiration and expiration
Ataxic: irregular
Patho:
1. increased ICP leads to decreased cerebral perfusion
2. leads to ischemia and cell death which stimulates further edema
3. shifting of brain tissue
4. herniation
5. death. this is bad.
complications:
1. brain stem herniation
a. cushings triad: rise in BP with widening pulse pressure, bradycardia, decrease respirations
2. diabetes insipidus: from pressure on the pituitary gland, lack of antidiuretic hormone.
3. syndrome of inappropriate antidiuretic hormone: too much antidiuretic hormone, sodium goes down to
due hemodilution
Management of ICP:
1. osmotic diuretics (mannitol)
2. corticosteroids (dexamethasone)
3. fluid restriction
4. hypothermia
5. reduce CSF and intracranial blood volume
a. ventriculostomy drain
b. hyperventilation will result in vasoconstriction (this reduces ICP)
6. Control temperature
a. antipyretic meds
b. cooling blanket
c. a shivering patient will have increased ICP
7. reduce metabolic demands
a. barbiturates: pentobarbital
b. paralyzing agents: pavulon
c. sedation: diprivan
d. analgesia: fentanyl
Intracranial surgery:
1. craniotomy: surgical opening of the skull
a. to relieve ICP
b. evacuate blood clot
c. control hemorrhage
d. remove a tumor
2. transphenoidal: mouth and nasal sinus to gain access to pituitary glands
3. Burr holes; exploration or diagnosing, evacuate hematoma or abscess
4. craniectomy: removal of portion of skull
5. cranioplasty: repair of cranial defect
Preoperative management:
1. antiseizure meds: dilantin, cerebx
2. Corticosteroids
3. fluid restrictions mannitol
4. antibiotics:
5. anxiolytic
Brain Injury:
1. Closed (blunt) brain injury: head accelerates and rapidly decelerates and collides with another object
2. Open brain injury: objects penetrates the skull, and damages the soft brain tissue
Types of brain injury:
1. Concussion: temporary loss of function with no apparent structural change
a. if frontal lobe is affected: bizarre behavior
b. temporal: amnesia
2. Contusion
a. unconscious for more than a few seconds or minutes
b. involuntary evacuation of bowels and bladder
c. shallow respirations, cool pale skin
d. B/P and temp subnormal
e. abnormal eye movement
f. body functions will eventually return to normal
g. full recovery days to months
h. vertigo, seizures, residual h/a are common
3. Diffuse axon injury
a. widespread damage to axons in the cerebral hemispheres, corpus callosum, and brain stem
b. mild to sever head trauma: axonal swelling and disconnection
c. severe, no lucid intervals and experiences immediate coma, decorticate and decerebrate
posturing, global cerebral edema
d. diagnosis: clinical signs plus CT or MRI
e. recovery depends on the severity of the axonal injury
4. Intracranial Hemorrhage: collection of blood, most serious brain injury
a. epidural: arterial blood between skull and dura, S/S: loss of consciousness, an apparent
recovery, then sudden signs of compression
b. Subdural; collection of blood between dura and the brain, can be acute and chronic, elderly and
alcoholics more susceptible, number one symptom: change in LOC
c. Intracerebral: bleeding into the substance of the brain: force is exerted to the head over a small
area (bullet wound), systemic HTN, saccular aneruysm, vascular anomalies. Management if
mostly dealing with ICP and supportive care.
5. Management of brain injuries
a. all treatment is towars preserving brain homeostasis and preventing secondary injury
b. cerebral edema, B/P, respirations, electrolyte imbalance, anti-hypertensives, head of bed 30-45
degrees, diuretics
Patho:
1. Transient concussion: usually 100 percent recovery
2. Contusion
3. Laceration
4. Compression
5. Transection: complete cutting of cord
Catagories:
1. Primary: initial trauma
2. Secondary: contusion or tear injury after the initial injury
Emergency Management:
1. rapid assessment
2. Immobilization
3. extrication (from vehicle if possible)
4. Stabilization
5. Transportation to close location
Complications: pg 1938
1. Spinal shock and neurogenic shock: develops due to loss of autonomic innervations below area of injury
a. the higher the injury on the spinal cord results in more areas that are affected
2. Respirations: especially the higher spinal cord injuries
a. decreased vital capacity
b. retention of secretions
c. increased CO2 levels
d. decreased O2 levels
e. respiratory failure
f. pulmonary edema
3. DVTs: increased risk for blood clots
4. Autonomic dysflexia
a. S/S: headache, profound sweating, nasal congestion, bradycardia, HTN, urinary retention
b. considered acute emergency from exaggerated autonomic responses to normal stimuli
c. occurs after spinal shock is resolved
d. triggered by: distended bladder, bowel distention, distention or contraction of visceral organs,
simulation of skin (break in skin, rash ect.)
e. need to remove triggering stimulus to avoid serious complications (check bladder first)
f. put in high fowlers to lower BP
Diagnostics: CT, MRI, PET, EEG, CSF (MRI the most helpful)
Medical management:
1. chemo
2. radiation
3. brachytherapy: inplanted radiation into system
4. bone marrow transplant
5. corticosteroids
Cerebral Aneurysm:
1. def: Dilation of the walls of the cerebral artery, often resulting from a weakness in arterial wall.
a. usually occurs around circle of willis
2. cause:
a. atherosclerosis
b. congential defect of vessel wall
c. hypertensive vascular disease
d. head trauma
e. age
f. multiple cerebral aneurysms are not uncommon
3. S/S:
a. sudden, severe headache, loss of consciousness (if aneurysm ruptures)
b. pain and rigidity in back of neck and spine
c. visual disturbance
d. tinnitus, dizziness, hemiparesis
e. coma and death.
4. Management:
a. prevent rupturing of aneurysm
b. aneurysm can be reinforced or ligated (clipped off) in surgery
c. extracranial-intracranial arterial bypass
d. bed rest
e. analgesics
f. elastic compression stockings to prevent DVT while on bed rest.