Normal Hematology Cell

Adhi Kristianto Sugianli

Objectives

Hematopoiesis
Process
Cell differentiation

Normal morphology of blood cell

Hematopoiesis

Red blood cell

Erythopoiesis
White Blood cell
Granulopoiesis
Lymphocyte
Lymphopoiesis
Thrombocyte
Thrombopoiesis
 Monocyte

Lymphocyte

Segmented Neutrophil Band Neutrophil

Lymphocyte Normal RBC

Normal Cell Maturation

Changes in cytoplasm
Changes in nucleus
Reduction in cell size
Gradual transformation
Changes are simultaneous and parallel
Changes in Cytoplasma

Loss of basophilia:
Romanowsky staining (Giemsa)
The more basophilic cytoplasma, the more
immature cell
Cytoplasmic granules in granulocytes
Azurophil (primary granules)
Specific (secondary granules)
Eosinophil
Basophil
Neutrophil
Elaboration of hemoglobin
Blue cytoplasm in pronormoblast and red cytoplasm
in erythrocyte
Changes in Nucleus

Nuclear Maturation
Shape
Round or oval in blasts
Striking changes in granulocytes
Structure delicate netlike or sponge like
Chromatin in blasts
Chromatin strands become more coarse and
clumped as the cells matures
Reduction in the number of nucleoli
Megakaryocytes
 Further Reading

Denise Harmening, Clinical Hematology and

Fundamentals of Hemostasis,
Publisher: FA Davis Company

Atlas of Hematology Nagoya University School of

Medicine,1996
http://pathy.med.nagoya-u.ac.jp/atlas/doc/

http://www.hematologyatlas.com/principalpage.htm
Thank You