1 5

1 CHILD ATTITUDE JOWARD JLLNESS SCALE

opics Prevalence I HLA-B27 in world populations HLA-B27 is not uncommon in the general population, but its
prevalence varies among different ethnic/racial groups throughout the world. This is shown in Table 3. The numbers
are rounded If for simplicity, and indicate percentage prevalence in the general population. For example, in the USA
approximately 8% I whites and 2-3% I AfreicanAmericans posses this gene, but it is much more common among the
native Americans. In general, AS and related diseases are more common in populations with a relatively higher
prevalence I HLA-B27, such as among the Inuit and Eskimos, and the converse is also true (Table 4). HLA-B27 and
AS are both absent from Australian aboriginal populations I unmixed genetic ancestry. However, there are some
exceptions o this generalization; e. g. AS is virtually absent in certain West African populations even though HLA-
B27 is present in up o 6% I them. Different CH2 H C CH3 CH3s I HLA-B27 So far, 25 different CH2 H C CH3 CH3s
I HLA-B27 (named B*2701 o B*2725) have been distinguished; most I them are quite rare. The presence I the
different HLA-B27 sub CH2 H C CH3 CH3s also differs markedly among the Table 3 Percentage prevalence I HLA-
B27 in different populations throughout the world. Native American linguistic population groups Eskimo-Aleut Eskimos
and Inuit Na-Dene Tlingit, Dogrib, and Navajo Amerind Bella co-ola Yakima and Pima Cree, Zuni and Chippewa
Papago, Hopi and Havasupai Mexican Mestizo Central American natives South American natives North and central
Asiatic linguistic population groups Chukchic Siberian Chuckchis Siberian Eskimo Uralic Ural mountain natives Samis
(Lapps) Altaic Siberians: Yakuts PIs Buryats Japanese Ainu (native Japanese) Koreans, Uygurs and Mongolians
Uzbeks, Kazakhs and Turkic populations Sino-Tibetan Chinese (mainland) Chinese (overseas) Tibetans Caucasoid
populations Ugro-Finnish Northern Scandinavians Slavic populations Western Europeans Caucasoid populations
Ugro-Finnish Northern Scandinavians Slavic populations Western Europeans Mediterranean Europeans Basques
Gypsies (Spain) Arabs, Jews, Armenians, and Iranians Pakistanis Indians (Asian) Other Asiatic populations South-
east Asians Vietnamese Khmer, Taiwanese aborigines and Filipinos 25-40 20-35 26 18-21 11-14 7-9 3-6 4-20 0 19-34 40 8-15 24 17-19 13 3-
6 4 9 8 6 9 2 2 1 1 1 7 1 6 9 6 1 1 1 1 6 8 6 5 8 3
1 3- 3- 2- 4- 1 1 - 8 0- 6 - 4 - 2- 9- 4 6- 8 - 6- 2- 9 - Table (contd) Indonesians, Malaysians and Thais Nauru
Guam Papua New Guineans Vanuatuans and New Caledonians Ouveans Fijians Hawaians, Samoans and
Marquesas Guineans Vanuatuans and New Caledonians Ouveans Fijians Hawaians, Samoans and Marquesas
Islanders Maoris Pokelau and Society Islanders Rapanui (Easter Islanders) Australian aborigines 5-12 2 5 12-26 18-23 11 4-6
3 3 0 3 5 1 6 0 1 0 0 0 3 0 7
2- 0- 0 0 - 2 2- 1 7- 0 0 0- . 0- . Micronesians Melanesians Polynesians North and West African populations North

Africans Arabs Berbers Ethiopians West Africans Gambia and Senegal Mali Equaorial and Southern African
populations pygmies San (Bushmen) Bantu Nigerians Zimbabweans South African Xhosas Zaireans various world
populations. For example, HLAB*2705 is the most common sub CH2 H C CH3 CH3 among white people, and the
Siberian and North American native populations, whereas HLA-B*2704 is the most common sub CH2 H C CH3 CH3
among the Chinese and Japanese populations, HLA-B*2706 (B*2722) is the most common sub CH2 H C CH3 CH3
among Indonesians, and HLA-B*2703 is only observed among West Africans or people with African ancestry. 24) HLA-
B27 and the cause I ankylosing spondylitis 5/29/02 Table 4 Recent prevalence studies I AS and related
spondyloarthropathies HLA-B27 frequency in general population (%) Eskimos (Alaska) Eskimos (Alaska and Siberia)
and Chukcki Samis (Lapps) Northern Norway Mordovia Western Europe Germany (Berlin) 40 25-40 Prevalence I AS
(%) in