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User 11952785Ahmed Ibrahim Mohammad Imran 11
A
Course Medical Immunology
Test The new exercises
Started 1/3/14 6:20 PM
Submitted 1/15/14 12:23 PM
Status Completed
Score 27 out of 195 points
Time Elapsed 282 hours, 3 minutes.
Instructions
Question 1
1 out of 1 points
a hapten
Answer
Selected Answer:
requires a carrier to initiate an immune response
Correct Answer:
requires a carrier to initiate an immune response
Question 2
0 out of 1 points
Binding of antigen to antibody

Answer
Selected Answer: [None Given]
Correct Answer:
Is optimized by spatial complementarity.
Question 3
0 out of 1 points
The intermolecular forces which contribute to the interaction between antibody

and antigen:
Answer
Correct Answer:
Rely on a combination of the above.
Question 4
0 out of 1 points
class II HLA molecules

Answer
Correct Answer:
present peptidic epitopes to CD4+ T helper cells
Question 5
0 out of 1 points
The processed peptide binding to the MHC class I groove:

Answer
Correct Answer:
Usually binds to the groove through 2 anchor residues.
Question 6
0 out of 1 points
TCR recognition of peptide-MHC class II depends on:

Answer
Correct Answer:
CDR-mediated binding.
Question 7
0 out of 1 points
CD1:
Answer
Correct Answer:
Can present lipid antigens.
Question 8
0 out of 1 points
A discontinuous antigen epitope is:

Answer
Selected [None Given]
Answer:
Correct
Answer: Produced by amino acid residues on non-adjacent polypeptide
sequences.
Question 9
0 out of 1 points
Superantigens:
Answer
Correct Answer:
Have to be processed before recognition by the T-cell.
Question 10
0 out of 1 points
Alpha beta T-cell receptors recognize:

Answer
Correct Answer:
Lipid and glycolipid antigens associated with the MHC.
Question 11
0 out of 1 points
Peptides produced by processing of cytosolic proteins largely:

Answer
Answer:
Correct
Answer: Are presented at the cell surface with MHC class I to CD8
cytotoxic T-cells.
Question 12
0 out of 1 points
Differentiation of antibody classes is a property of

Answer
Correct Answer:
CH chain region
Question 13
0 out of 1 points
The immunoglobulin that has four subclasses is

Answer
Correct Answer:
IgG
Question 14
0 out of 1 points
The secretory piece

Answer
Answer:
Correct Answer:
?Is a poly Ig receptor on the membranes of mucosal
epithelial cells
Question 15
0 out of 1 points
Antiserum developed in rabbits against pooled human IgA will react with human
Answer
Correct Answer:
Each of the above
Question 16
0 out of 1 points
The antigenic determinants defining the 5 Ig isotypes are associated with

Answer
Correct Answer:
Heavy chains
Question 17
0 out of 1 points
The basic Ig unit is composed of:
Answer
Correct Answer:
2 identical heavy and 2 identical light chains.
Question 18
0 out of 1 points
The Fc fragment of an IgG antibody:

Answer
Correct Answer:
is characterized by all of the above.
Question 19
0 out of 1 points
The complementarity determining regions:

Answer
Correct Answer:
Are concerned in antigen recognition.
Question 20
0 out of 1 points
A Fab fragment:
Answer
Correct Answer:
Binds antigen.
Question 21
0 out of 1 points
Cleavage of IgG by papain produces:

Answer
Correct Answer:
Fab.
Question 22
0 out of 1 points
Which class Ig can form a dimer?

Answer
Correct Answer:
lgA
Question 23
0 out of 1 points
___ is the natural antibodies against blood cell determinants.

Answer
Correct Answer:
lgM
Question 24
0 out of 1 points
The mucosal surfaces of the body are initially protected by free:

Answer
Correct Answer:
Secretory IgA.
Question 25
0 out of 1 points
Secretory IgA protects external mucosal surfaces by:

Answer
Correct Answer:
Preventing microbial adherence to the mucosa.
Question 26
0 out of 1 points
IgM:
Answer
Correct Answer:
Is the main class of the 'natural antibodies'.
Question 27
0 out of 1 points
IgD:
Answer
Correct Answer:
Is present mainly as a surface receptor on B-cells.
Question 28
0 out of 1 points
The mononuclear phagocyte system does not include:

Answer
Correct Answer:
Endothelial cells.
Question 29
0 out of 1 points
A polymorphonuclear neutrophil (PMN):

Answer
Correct Answer:
Contains microbicidal cytoplasmic granules.
Question 30
0 out of 1 points
The membrane attack complex of complement system consists of:

Answer
Correct Answer:
"C5b,6,7,8,9"
Question 31
0 out of 1 points
C3b
Answer
Correct Answer:
Opsonizes bacteria.
Question 32
0 out of 1 points
Lysozyme:
Answer
Correct Answer:
Splits peptidoglycan.
Question 33
0 out of 1 points
Virally infected cells can be killed directly by:

Answer
Correct Answer:
NK cells
Question 34
0 out of 1 points
The specialized cell type involved in the entry of lymphocytes into lymph nodes
are called:
Answer
Correct Answer:
HEV endothelial cells
Question 35
0 out of 1 points
The spleen is largely involved with the response to antigens which are in the:
Answer
Correct Answer:
Blood
Question 36
0 out of 1 points
The germinal centers found in the cortical region of lymph nodes and peripheral
region of splenic periarteriolar lymphatic tissue
Answer
Answer:
Correct
Answer: Provide an infrastructure that on antigenic stimulation contains
large population of B lymphocytes and plasma cells.
Question 37
0 out of 1 points
The development of self-tolerance in the T-cell compartment is important for the

prevention of autoimmunity. Which of the following results in T-cell self-
tolerance?
Answer
Correct Answer:
negative selection
Question 38
0 out of 1 points
Where are B-lymphocytes developed?
Answer
Correct Answer:
Bone marrow
Question 39
1 out of 1 points
The function of the B-cell receptor (BCR) is to

Answer
Selected Answer:
recognize foreign antigens
Correct Answer:
recognize foreign antigens
Question 40
1 out of 1 points
____ is the most important co-stimulatory molecule during B cell activation?

Answer
Selected Answer:
CD40
Correct Answer:
CD40
Question 41
1 out of 1 points
Stages of B cell development in bone marrow does NOT include:

Answer
Selected Answer:
Plasma B
Correct Answer:
Plasma B
Question 42
1 out of 1 points
Which molecule is responsible for triggering a cascade of biochemical signal

after mIg binds to specific antigen?
Answer
Selected Answer:
CD79a/79b
Correct Answer:
CD79a/79b
Question 43
1 out of 1 points
"During maturation, B cell check and dispose self-reactive B cells at ( ) stages."

Answer
Selected Answer:
Immature B
Correct Answer:
Immature B
Question 44
1 out of 1 points
Which molecule of B-1 and B-2 is different?

Answer
Selected Answer:
CD5
Correct Answer:
CD5
Question 45
1 out of 1 points
Cytokines always act:

Answer
Selected Answer:
by binding to specific receptors.
Correct Answer:
by binding to specific receptors.
Question 46
1 out of 1 points
Cytokines are NOT:

Answer
Selected Answer:
synthesized for a long time
Correct Answer:
synthesized for a long time
Question 47
1 out of 1 points
Which cytokine plays an important role in innate immunity to combat viral

replication?
Answer
Selected Answer:
IFNs
Correct Answer:
IFNs
Question 48
1 out of 1 points
B1 cells express which of the following molecule?

Answer
Selected Answer:
CD5
Correct Answer:
CD5
Question 49
0 out of 1 points
Which of the following molecule is essential for B cell activation?

Answer
Correct Answer:
CD40
Question 50
1 out of 1 points
"During primary antibody response, B cells initially produce which type of

antibody?"
Answer
Selected Answer:
IgM
Correct Answer:
IgM
Question 51
0 out of 1 points
"On the B cell surface, receptors for antigen are associated with"
Answer
Correct Answer:
Ig and Ig
Question 52
1 out of 1 points
Which of the following is not feature of the immune response to TD antigens?

Answer
Selected Answer:
Mainly IgM production
Correct Answer:
Mainly IgM production
Question 53
0 out of 1 points
Which of the following is not feature of plasma cells?

Answer
Correct Answer:
BCR expression
Question 54
0 out of 1 points
Which of the following is not right for isotype switching?

Answer
Correct Answer:
Change in VH genes
Question 55
0 out of 1 points
Which of the following is right for somatic hypermutation?

Answer
Correct Answer:
Point mutations of VH or VL gene
Question 56
1 out of 1 points
Which of the following is not right for primary immune response?

Answer
Selected Answer:
mainly IgG production
Correct Answer:
mainly IgG production
Question 57
1 out of 1 points
Which of the following description is right for memory B cells?

Answer
Selected Answer:
long-lived
Correct Answer:
long-lived
Question 58
1 out of 1 points
Which cell type is most potent antigen-presenting cells

Answer
Selected Answer:
Dendritic cell
Correct Answer:
Dendritic cell
Question 59
1 out of 1 points
Which cell type could initiate immune response

Answer
Selected Answer:
Dendritic cell
Correct Answer:
Dendritic cell
Question 60
1 out of 1 points
Antigen presentation does not need:

Answer
Selected Answer:
antibody
Correct Answer:
antibody
Question 61
1 out of 1 points
The principle function of immature dendritic cell is:
Answer
Selected Answer:
antigen capture
Correct Answer:
antigen capture
Question 62
1 out of 1 points
The principle function of mature dendritic cell is:

Answer
Selected Answer:
antigen presentation
Correct Answer:
antigen presentation
Question 63
0 out of 1 points
Which cell type could be target APC

Answer
Selected Answer:
T cell
Correct Answer:
Tumor cell
Question 64
1 out of 1 points
Which cell type belong to migratory dendritic cell:

Answer
Selected Answer:
langerhans cells
Correct Answer:
langerhans cells
Question 65
1 out of 1 points
Which molecule could present lipid antigen:

Answer
Selected Answer:
CD1a
Correct Answer:
CD1a
Question 66
1 out of 1 points
Which is wrong for the following statements about immunoregulation:

Answer
Selected Answer:
Immunoregulation just occurs in the immune system.
Correct Answer:
Immunoregulation just occurs in the immune system.
Question 67
0 out of 1 points
The character of inhibitory Th-cell is :

Answer
Correct Answer:
Suppress the activated Th cell through secretory cytokines.
Question 68
0 out of 1 points
The targeted cell of T cell inhibitory factor (TsF):

Answer
Correct Answer:
Activated CD4+Th cell
Question 69
1 out of 1 points
Which is wrong about Th1 and Th2 in the following statements?

Answer
Selected Answer:
Th1 and Th2 can be switched each other
Correct Answer:
Th1 and Th2 can be switched each other
Question 70
0 out of 1 points
Whats wrong about immune tolerance in the following?

Answer
Correct Answer:
is the synonym to immune inhibitory
Question 71
0 out of 1 points
The antigen-injection manner which easily leads to cause immune tolerance
Answer
Correct Answer:
"vein injection peritoneal subcutaneous, muscular"
Question 72
0 out of 1 points
The natural immune tolerance usually refers to:

Answer
Correct Answer:
Body has no response to itself component
Question 73
0 out of 1 points
B cell form the immune tolerance:

Answer
Correct Answer:
Maintanence time is short
Question 74
0 out of 1 points
Which cell is the easiest cell to be induced to immune tolerance:

Answer
Correct Answer:
T cell
Question 75
0 out of 1 points
Defects in neutrophil NADPH oxidase system produce:

Answer
Correct Answer:
Chronic granulomatous disease.
Question 76
0 out of 1 points
Paroxysmal nocturnal hemoglobulinuria results from deficiency in:

Answer
Correct Answer:
Decay accelerating factor. (DAF).
Question 77
0 out of 1 points
X-linked agammaglobulinemia results from a mutation in:

Answer
Correct Answer:
Bruton's tyrosine kinase (Btk) gene
Question 78
1 out of 1 points
Di George syndrome results from a defect in:

Answer
Selected Answer:
Thymic development.
Correct Answer:
Thymic development.
Question 79
1 out of 1 points
"Mutations in the gammac chain of the receptors for IL-2, 4, 7, 9 and 15 lead to:"
Answer
Selected Answer:
Severe combined immunodeficiency (SCID).
Correct Answer:
Severe combined immunodeficiency (SCID).
Question 80
0 out of 1 points
Poor skin tests to a range of microbial antigens such as tuberculin and mumps
indicate a deficiency of:
Answer
Correct Answer:
T-cells.
Question 81
0 out of 1 points
HIV binds to:

Answer
Correct Answer:
CD4.
Question 82
0 out of 1 points
A coreceptor for HIV is:

Answer
Correct Answer:
CXCR4
Question 83
0 out of 1 points
Which of the following HIV antigens provides a potential target for neutralizing
antibody:
Answer
Correct Answer:
??gp120
Question 84
0 out of 1 points
Primary immunodeficiency producing susceptibility to infection by viruses and

molds is due to:
Answer
Correct Answer:
T-cell deficiency.
Question 85
0 out of 1 points
Which of the following is not helpful in the diagnosis of AIDS:
Answer
Correct Answer:
CD8 numbers.
Question 86
0 out of 1 points
Deletions in the T-cell CD154 (CD40L) gene produce:

Answer
Correct Answer:
The hyperCIgM syndrome.
Question 87
0 out of 1 points
Which of the following have not provided examples of secondary

immunodeficiency:
Answer
Correct Answer:
High fat diet.
Question 88
0 out of 1 points
?A graft between members of the same species is termed an:

Answer
Correct Answer:
Allograft.
Question 89
0 out of 1 points
Which one of the following statements is false. Rejection of a second (set) skin
graft from the same allogeneic donor:
Answer
Correct Answer:
?Proceeds at the same speed as the first graft rejection.
Question 90
0 out of 1 points
The human major histocompatibility complex:

Answer
Correct Answer:
Provokes the most intense allograft reactions.
Question 91
0 out of 1 points
Mitosis occurs when mixing lymphocytes of two individuals:

Answer
Correct Answer:
Of differing MHC class II haplotype.
Question 92
0 out of 1 points
Non-specific suppression of graft rejection can be achieved with:
Answer
Correct Answer:
Anti-CD3
Question 93
0 out of 1 points
?Pigs have been proposed as a source of organs for xenotransplantation to

humans because:
Answer
Answer:
Correct
Answer: Their hearts are an appropriate size and the pigs can be
genetically modified to limit the possibility of hyperacute
rejection.
Question 94
0 out of 1 points
Graft vs host disease often accompanies transplantation of:

Answer
Correct Answer:
?Bone marrow.
Question 95
0 out of 1 points
?The very rapid response to a second allogeneic graft is:

Answer
Answer:
Correct
Answer: Specific for antigens of the major histocompatibility complex
(MHC).
Question 96
0 out of 1 points
"Concerning MHC class II antigen differences between 2 individuals, which of

the following is untrue:"
Answer
Correct Answer:
There are MHC class II antigens on all of cells in
individuals
Question 97
0 out of 1 points
Hyperacute graft rejection is caused by:

Answer
Correct Answer:
Preformed antibody.
Question 98
0 out of 1 points
Which of the following allogeneic grafts does not require immunosuppression:

Answer
Correct Answer:
?Cartilage.
Question 99
0 out of 1 points
The single best chance of a tissue graft being accepted in a human recipient is if
it is:
Answer
Correct Answer:
An isograft
Question 100
0 out of 1 points
"Out of the following, the cadaveric organ with the best survival 10-years post-
transplant is:"
Answer
Correct Answer:
Liver
Question 101
0 out of 1 points
Type-I hypersensitivity is mediated by

Answer
Correct Answer:
IgE
Question 102
0 out of 1 points
Immediate hypersensitivity usually involves

Answer
Correct Answer:
Mast cells
Question 103
0 out of 1 points
Therapy of allergic disease does not include

Answer
Correct Answer:
Increase T cells making IL-4
Question 104
0 out of 1 points
Hemolytic disease of the newborn is

Answer
Correct Answer:
Type-II hypersensitivity
Question 105
0 out of 1 points
The response of delayed hypersensitivity

Answer
Answer:
Correct
Answer: Shows erythema (redness) and induration 1-2 days after
injection of the antigen
Question 106
0 out of 1 points
Which of the following factor is not usually involved in Type-I hypersensitivity

Answer
Correct Answer:
IgG
Question 107
0 out of 1 points
Which of the following disease is systemic hypersensitivity?

Answer
Correct Answer:
Anaphylaxis shock
Question 108
0 out of 1 points
Which of the following factor is not usually involved in Type-III hypersensitivity

Answer
Correct Answer:
Th1 cells
Question 109
0 out of 1 points
Which of the following disease is not Type-III Hypersensitivity

Answer
Correct Answer:
PPD skin test
Question 110
0 out of 1 points
Which of the following factor is not usually involved in Type-IV hypersensitivity

Answer
Correct Answer:
IgG
Question 111
0 out of 1 points
Which disease is caused by the accumulation of autoantigen-antibody complex?

Answer
Correct Answer:
Systemic lupus erythematosis
Question 112
0 out of 1 points
Which disease is caused by the IgG antibody against cellular receptor?

Answer
Correct Answer:
Grave's disease
Question 113
0 out of 1 points
Anti-nuclear antibodies (ANA) are diagnostic for

Answer
Correct Answer:
Question 114
0 out of 1 points
Autoimmune hemolytic anemia is mediated by

Answer
Correct Answer:
autoantibody against cell membrane
Question 115
0 out of 1 points
Which of the following auto-immune diseases belong to the systemic

autoimmune diseases?
Answer
Correct Answer:
Question 116
0 out of 1 points
Multiple sclerosis is mediated by

Answer
Correct Answer:
T lymphocytes
Question 117
0 out of 1 points
Which of the following statements on autoimmune diseases is wrong?

Answer
Correct Answer:
Women have a higher incidence in all diseases than men
Question 118
0 out of 1 points
Activation of adaptive immunity is required for initiation of innate immune

reactions
Answer
Correct Answer: True
Question 119
0 out of 1 points
IgG antibodies predominate in typical secondary humoral responses

Answer
Question 120
0 out of 1 points
"The antigen combining site of an antibody will typically be made up of VL,

VH, and carbohydrate "
Answer
Question 121
0 out of 1 points
The innate immune response is activated by pattern recognition of PAMPs

expressed on invading pathogens.
Answer
Question 122
0 out of 1 points
The apative immune system mainly consists of T and B lymphocytes and works
by clonal selection.
Answer
Question 123
0 out of 1 points
C5a is a complement component which is strongly chemotactic for neutrophils.

Answer
Question 124
0 out of 1 points
NK cells kill the target cells in an extracellular fashion.

Answer
Correct Answer: False
Question 125
0 out of 1 points
NK cells kill target cells by phagocytosis and intracellular digestion.

Answer
Question 126
0 out of 1 points
Lymphocytes in the lamina propria secrete large amounts of IgA.

Answer
Question 127
0 out of 1 points
The major cell type in the paracortical area of a lymph node is T lymphocyte.
Answer
Question 128
0 out of 1 points
"M cells are specialized cells located in the follicle-associated epithelium of the
Peyer's patch which selectively take up Ag, and transport Ag to intraepithelial
macrophages and lymphocytes. "
Answer
Question 129
0 out of 1 points
Maturation of T cells in the thymus requires the presence of foreign antigen.

Answer
Question 130
0 out of 1 points
CD3 is a major marker retained on all peripheral T cells.

Answer
Question 131
0 out of 1 points
The B cell development in bone marrow does not require foreign antigen.
Answer
Question 132
0 out of 1 points
B-lymphocytes can act as antigen-presenting cells (APCs).

Answer
Question 133
0 out of 1 points
Mature B cells expresses IgM and IgD.

Answer
Question 134
0 out of 1 points
Pro-B cells does not express CD79a/CD79b.

Answer
Question 135
0 out of 1 points
B-2 cells are the major B-cell type in the peritoneum.

Answer
Question 136
0 out of 1 points
The majority antibodies that B-1 cells produce are IgM.

Answer
Question 137
0 out of 1 points
Cytokines can not be produced by non-immune cells.

Answer
Question 138
0 out of 1 points
Some type I cytokine receptors share a common subunit.

Answer
Question 139
0 out of 1 points
Cytokines can only bind to neighbor cell receptor or self receptor.

Answer
Question 140
0 out of 1 points
One type of cytokines can only be produced by one type of cells.

Answer
Question 141
0 out of 1 points
CD3 is the important signaling molecule for B cell activation.

Answer
Question 142
0 out of 1 points
CD19 is one of the components of B cell co-receptor.

Answer
Question 143
0 out of 1 points
Memory B cells are long-lived low-proliferating cells.

Answer
Question 144
0 out of 1 points
CD28 is the second signaling molecule for B cell activation.

Answer
Question 145
0 out of 1 points
CD32 could enhance the signaling by the BCR complex.

Answer
Question 146
0 out of 1 points
CD21 could enhance B cell activation signal significantly.

Answer
Question 147
0 out of 1 points
Somatic hypermutation refer to point mutations of CH or CL gene.

Answer
Question 148
0 out of 1 points
Somatic hypermutation has no influence on specificity and affinity of BCR.

Answer
Question 149
0 out of 1 points
Plasma cells express BCR and MHC- molecule.

Answer
Question 150
0 out of 1 points
"Compared with primary immune responses, secondary immune responses need

lower concentrations of Ag stimulation."
Answer
Question 151
0 out of 1 points
T lymphocytes can recognize antigen in solution.

Answer
Question 152
0 out of 1 points
B lymphocytes belong to professional antigen-presenting cells

Answer
Question 153
0 out of 1 points
MHC molecules are expressed on T lymphocytes.

Answer
Question 154
0 out of 1 points
Endothelial cells are non-professional antigen-presenting cells.

Answer
Question 155
0 out of 1 points
Macrophages are most potent antigen-presenting cells

Answer
Question 156
0 out of 1 points
Langerhans cells are dendritic cell located in skin

Answer
Question 157
0 out of 1 points
MHC-I molecule present endogenous antigens to CD8+ T cells

Answer
Question 158
0 out of 1 points
MHC-II molecule present exogenous antigens to CD4+ T cells

Answer
Question 159
0 out of 1 points
The activation of CD4 T cells could cause death of target cells.

Answer
Question 160
0 out of 1 points
The activation of CD8 T cells could cause upregulation of immune responses.

Answer
Question 161
0 out of 1 points
Immune system responds in distinct way to different antigen.

Answer
Question 162
0 out of 1 points
Immunoregulation is antigen specific.

Answer
Question 163
0 out of 1 points
Lack of co-stimulation can lead to the passive death of activated T cell.

Answer
Question 164
0 out of 1 points
CTLA4 engagement inhibits activated T cells by competing for B7

(CD80/CD86).
Answer
Question 165
0 out of 1 points
Neuroendocrine system is not involved in the immunoregulation.

Answer
Question 166
0 out of 1 points
IFN- secreted by Th1 cells promotes further Th2 differentiation and inhibits
the proliferation of Th1 cells.
Answer
Question 167
0 out of 1 points
Certain antigens given subcutaneously or intramuscularly may be more
immunogenic than when given intravenously or intraperitoneally.
Answer
Question 168
0 out of 1 points
Large doses are needed for tolerance in adults compared neonates.

Answer
Question 169
0 out of 1 points
Tolerance is easier to achieve before birth or in early neonatal life.

Answer
Question 170
0 out of 1 points
Elimination of antigen leads to spontaneously termination of immunotolerance.

Answer
Question 171
0 out of 1 points
FK506 inhibits IL-12 production.
Answer
Question 172
0 out of 1 points
HLA-G involves in the fetal transplantation

Answer
Question 173
0 out of 1 points
Transplants from parents to siblings have a 50% match of HLA alleles

Answer
Question 174
0 out of 1 points
Sibling to sibling grafts have a 50% chance of having identical HLA alleles.
Answer
Question 175
0 out of 1 points
Cornea transplants can usually be accepted.
Answer
Question 176
0 out of 1 points
Type-III hypersensitivity is also called delayed-type hypersensitivity.

Answer
Question 177
0 out of 1 points
Serum sickness is a kind of type-II hypersensitivity.

Answer
Question 178
0 out of 1 points
The effector phase of allergic reaction includes acute phase and late phase
reaction.
Answer
Question 179
0 out of 1 points
The clinical signs of localized allergic reactions depends on portal of entry.
Answer
Question 180
0 out of 1 points
Type-II hypersensitivity reaction is often the combined activities of complement

and antibodies.
Answer
Question 181
0 out of 1 points
Drug-induced hemolytic anemia is a kind of type- III hypersensitivity.

Answer
Question 182
0 out of 1 points
Incompatible blood transfusion would lead to the occurrence of type-IV

hypersensitivity.
Answer
Question 183
0 out of 1 points
The mechanism of Graves disease is type- III hypersensitivity.
Answer
Question 184
0 out of 1 points
Type-III hypersensitivity can cause both localized and systemic reactions.

Answer
Question 185
0 out of 1 points
Intracellular pathogens and contact antigens could cause delayed-type

hypersensitivity.
Answer
Question 186
0 out of 1 points
No auto-antibody is present in healthy people.

Answer
Question 187
0 out of 1 points
Women have a greater risk in development of all autoimmune diseases than men.
Answer
Question 188
0 out of 1 points
Autoimmune diseases are often associated with pathogen infection

Answer
Question 189
0 out of 1 points
Auto-antigens are often high-conserved proteins.

Answer
Question 190
0 out of 1 points
Deficiency in complement components might lead to auto-immune diseases.

Answer
Question 191
0 out of 1 points
Antigens sequestered in hidden locations might become auto-antigens
Answer
Question 192
0 out of 1 points
The pathogenesis of autoimmune diseases are associated with all type

hypersenstivities.
Answer
Question 193
0 out of 1 points
Infant might suffer from Grave's disease due to the auto-antibody against TSHR
derived from mother.
Answer
Selected Answer: False
Question 194
1 out of 1 points
Rheumatoid arthritis is an organ specific autoimmune diseases

Answer
Selected Answer: False
Question 195
0 out of 1 points
Some autoimmune diseases are closely associated with MHC genotype.
Answer
Wednesday, January 15, 2014 12:24:17 PM CST
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Review Test Submission: The new

Binding of antigen to antibody

The intermolecular forces which contribute to the interaction between antibody

class II HLA molecules

The processed peptide binding to the MHC class I groove:

TCR recognition of peptide-MHC class II depends on:

A discontinuous antigen epitope is:

Alpha beta T-cell receptors recognize:

Peptides produced by processing of cytosolic proteins largely:

Differentiation of antibody classes is a property of

The immunoglobulin that has four subclasses is

The secretory piece

The antigenic determinants defining the 5 Ig isotypes are associated with

The Fc fragment of an IgG antibody:

The complementarity determining regions:

Cleavage of IgG by papain produces:

Which class Ig can form a dimer?

___ is the natural antibodies against blood cell determinants.

The mucosal surfaces of the body are initially protected by free:

Secretory IgA protects external mucosal surfaces by:

The mononuclear phagocyte system does not include:

A polymorphonuclear neutrophil (PMN):

The membrane attack complex of complement system consists of:

Virally infected cells can be killed directly by:

The development of self-tolerance in the T-cell compartment is important for the

The function of the B-cell receptor (BCR) is to

____ is the most important co-stimulatory molecule during B cell activation?

Stages of B cell development in bone marrow does NOT include:

Which molecule is responsible for triggering a cascade of biochemical signal

"During maturation, B cell check and dispose self-reactive B cells at ( ) stages."

Which molecule of B-1 and B-2 is different?

Cytokines always act:

Cytokines are NOT:

Which cytokine plays an important role in innate immunity to combat viral

B1 cells express which of the following molecule?

Which of the following molecule is essential for B cell activation?

"During primary antibody response, B cells initially produce which type of

Which of the following is not feature of the immune response to TD antigens?

Which of the following is not feature of plasma cells?

Which of the following is not right for isotype switching?

Which of the following is right for somatic hypermutation?

Which of the following is not right for primary immune response?

Which of the following description is right for memory B cells?

Which cell type is most potent antigen-presenting cells

Which cell type could initiate immune response

Antigen presentation does not need:

The principle function of mature dendritic cell is:

Which cell type could be target APC

Which cell type belong to migratory dendritic cell:

Which molecule could present lipid antigen:

Which is wrong for the following statements about immunoregulation:

The character of inhibitory Th-cell is :

The targeted cell of T cell inhibitory factor (TsF):

Which is wrong about Th1 and Th2 in the following statements?

Whats wrong about immune tolerance in the following?

The natural immune tolerance usually refers to:

B cell form the immune tolerance:

Which cell is the easiest cell to be induced to immune tolerance:

Defects in neutrophil NADPH oxidase system produce:

Paroxysmal nocturnal hemoglobulinuria results from deficiency in: