Insufficient Insulin/insulin

resistance

Reduced tissue uptake of

glucose

Intracellular Extracellular Blood viscosity Retinopathy

hypoglycemia hyperglycemia Neuropathy
Nephropath
Decreased blood y
glycogenolysis Hyperosmotic Renal flow to O2 kidney
plasma threshold of
blood
gluconeogenesis Stimulate renin
Dehydration release
of cells glucosuria

Breakdown Decreased protein Converted

of fats synthesis angiotensin I
Hypoglycemic Osmotic diuresis
coma (polyuria)
Converted
High level Cachexa
angiotensin II
of ketones Lethargy
Poyphagia Polydipsia
Decreased Vasoconstriction
Diabetic gamma
ketoacidosi globulins
s Myocardial infarction
Suscep
Cerebrovascular disease
tibility
Peripheral vascular dse.
to