BAB III

METODE KERJA

III.1 RANCANGAN FORMULA

R/ Difenhidramin HCl

III.2 FORMULA YANG DISETUJUI

Tiap 250 mg mengandung :
Difenhidramin HCl 25 mg
Talk 2%
Mg. Stearat 1%
PVP 5%
Amilum Manihot (Intragranular) 7,5%
Amilum Manihot (Extragranular) 2,5%
Potasium Sorbat 0,1%
Avicel pH 102 ad 100%

III.3 PERHITUNGAN BAHAN

Dibuat 30 tablet :
Tiap tablet 250 mg dilebihkan 10% = 275 mg x 30 tab = 8250 mg
1. Difenhidramin HCl = 25 mg x 30 tab = 750 mg
2. Talk = 2% x 275 mg = 5,5 mg x 10% = 6,05 mg x 30 tab = 181,5 mg
3. Mg. Stearat = 1% x 275 mg = 2,75 mg x 10% = 3,025 mg x 30 tab =
90,75 mg
4. PVP = 5% x 275 mg = 13,75 mg x 10% = 15,125 mg x 30 tab
= 453,75 mg
5. Amilum Manihot (Intragranular) = 7,5% x 275 mg = 20,62 mg x 10%
= 22,682 mg x 30 tab = 680,46 mg
6. Amilum Manihot (Extragranular) = 2,5% x 275 mg = 6,9 mg x 10%
= 7,59 mg x 30 tab = 227,7 mg
7. Potasium Sorbat = 0,1% x 275 mg = 0,27 mg x 10% = 0,297 mg x 30
tab = 8,91 mg
8. Avicel pH 102 ad 100% = 275 mg x 30 tab = 8250 mg
8250 mg – (750 mg + 181,5 mg + 90,75 mg + 453,75 mg + 680,46 mg +
227,7 mg + 8,91 mg) = 8250 mg – 2393,07 mg = 5856,93 mg