CLASSIFICATIONS OF ANEMIA & LEUKEMIA (TUTOY)

CLASSIFICATIONS OF ANEMIA

I. ANEMIA OF BONE MARROW FAILURE AND SYSTEMIC DISORDERS a. Pancellular HPHF

(NORMO/NORMO) b. Heterocellular HPHF
4. Other Thalassemias
1. APLASTIC ANEMIA a. ᵝᵞᵟ Thalassemia
a. Acquired Aplastic Anemia (could be macro/normo) b. ᵞ Thalassemia
b. Inherited Aplastic Anemia c. ᵟ Thalassemia
 Fanconi Anemia (Congenital Aplastic Anemia)
 Dyskeratosis Congenita V. ANEMIA OF ABNORMAL GLOBIN DEVELOPMENT –
 Schwachman-Bodian-Diamond syndrome HEMOGLOBINOPATHY (NORMO/NORMO)

2. PURE RED CELL ANEMIA 1. Beta chain substitution

a. Acquired PRCA a. Sickle cell Anemia
b. Diamond-Blackfan Anemia (Congenital PRCA) (could be b. Sickle cell Trait
macro/normo) c. Hb-S Thalassemia (micro/hypo)
d. Hb C Disease
3. MYELOPHTHISIC ANEMIA e. Hb C Trait
4. ANEMIA OF SYSTEMIC DISORDERS f. Hb SC disease
a. Anemia of Chronic Renal Disease g. Hb D (rare)
b. Anemia of Endocrine Disorders h. Hb SD
c. Anemia of Pregnancy i. Hb E
2. Multiple amino acid substitution
II. ANEMIA OF ABNORMAL NUCLEAR DEVELOPMENT a. Hb-C Harlem
(MACRO/NORMO) 3. Alpha chain substitutions
a. Hb G – Philadelphia
1. Megaloblastic Anemia 4. Other variants
a. Hb I
III. ANEMIA OF ABNORMAL IRON METABOLISM & HEME SYNTHESIS 5. Amino Acid deletions
(MICRO/HYPO) a. Hb Gun Hill
6. Elongation of Polypeptide chain
1. Iron Deficiency Anemia a. Hb Constant spring
2. Anemia of Chronic Disorders (ACD) (could be normo/normo) 7. Unstable Hemoglobin Disease/Congenital Heinz Body
3. Sideroblastic Anemia Hemolytic Anemia
a. Hereditary a. Hb Koln
 ALA Synthase Deficiency 8. Hemoglobin M
b. Acquired a. Hb M – Boston
 Idiopathic (primary) b. Hb M – Iwate
 Secondary Type) c. Hb M – Saskatoon
4. Lead Intoxication d. Hb M – Hyde Park
5. Hemochromatosis e. Hb M – Milwaukee
6. Porphyria 9. Hemooglobins with increased oxygen affinity
a. Primary (inherited) a. Hb Chesapeake
b. Secondary (acquired) 10. Hemoblobin with decreased oxygen affinity
a. Hb Kansas
IV. ANEMIA OF ABNORMAL GLOBIN DEVELOPMENT –
THALASSEMIAS (MICRO/HYPO)

1. Alpha Thalassemia VI. HEREDITARY ANEMIAS OF INCREASE DESTRUCTION

a. Bart Hydrops Fetalis/Hb Bart (4 gamma)
b. Hb H disease 1. Erythrocyte Membrane Abnormalities
c. Hb H – Constant Spring a. Hereditary Spherocytosis (micro/hyper)
d. Alpha Thalassemia minor (alpha thalassemia trait) b. Hereditary Elliptocytosis (normo/normo)
e. Silent Carrier  Common HE
 Spherocytic HE
 Southeast Asian ovalocytosis/Stomatocytic HE
2. Beta Thalassemia c. Hereditary Pryopoikilocytosis (micro/normo)
a. Beta Thalassemia Major d. Hereditary Stomatocytosis/Hereditary Xerocytosis
b. Beta Thalassemia Intermedia (macro/hyper)
c. Beta Thalassemia Minor 2. Hereditary Erythrocyte Enzymopathies
d. Beta Thalassemia Minima (Silent B Thalassemia trait) a. Pyruvate Kinase Deficiency
3. Hereditary Persistence of Fetal Hemoglobin b. G6PD Deficiency (Class 1-5)
 CLASSIFICATIONS OF ANEMIA & LEUKEMIA (TUTOY)

3. Hereditary Plasma Constituent Abnormalities

a. Abetalipoproteinema
b. LCAT Deficiency

VII. ACQUIRED NONIMMUNE ANEMIA OF INCREASED DESTRUCTION

1. Microangiopathic Hemolytic Anemia

a. Acquired Extracorposcular Defects
 Disseminated Intravascular Coagulation (DIC)
 Thrombotic Thrombocytopenic Purpura (TTP)
 Hemolytic Uremic Syndrome (HUS)
 HELLP Syndrome
2. Macroangiopathic Hemolytic Anemia
a. Abnormal blood vessel structure
b. Mechanical Injury to Erythrocytes
3. Acquired Intracorposcular Defect
a. Paroxysmal Nocturnal Hemoglobinuria

VIII. ACQUIRED IMMUNE ANEMIA OF INCREASED DESTRUCTION

1. Isoimmune HA
a. Hemolytic Disease of the Newborn (HDN)
b. Hemolytic Transfusion Reaction (HTR)
2. Autoimmune HA
a. WAIHA
b. CAIHA
c. Paroxysmal Cold Hemoglobinuria
3. Drug-induced HA

IX. ANEMIA OF BLOOD LOSS

1. Acute bleeding
2. Chronic Bleeding
 CLASSIFICATIONS OF ANEMIA & LEUKEMIA (TUTOY)

CLASSIFICATIONS OF LEUKEMIA

I. MYELODYSPLASTIC SYNDROME (MDS) h. M7 – Acute Megakaryocytic Leukemia

1. FAB Classification V. ACUTE LYMPHOBLASTIC LEUKEMIA

a. Refractory Anemia (RA) 1. L1
b. Refractory Anemia with Ringed Sideroblasts 2. L2
(RARS) 3. L3
c. Refractory Anemia with Excess Blasts (RAEB)
d. Chronic Myelomonocytic Leukemia (CMML) VI. CHRONIC LYMPHOPROLIFERATIVE LEUKEMIA
e. Refractory Anemia w/ Excess blast in
Trasformation (RAEBIT) 1. Chronic Lymphocytic Leukemia
2. WHO Classification a. B-cell CLL
a. MDS-SLD 2. Prolymphocytic Leukemia
b. MDS-MLD a. B-cell PLL
c. MDS-RS b. T-cell PLL
d. MDS-EB 3. Hairy Cell Leukemia
e. MDS-U 4. Large Granular Lymphocytic Leukemia
a. T lymphocyte
II. MYELODYSPLASTIC SYNDROME/MYELOPROLIFERATIVE b. NK cell
NEOPLASMS (MDS/MPN)
VII. LYMPHOMA
1. Chronic Myelomonocytic Leukemia (CMML)
2. Atypical Myelomonocytic Leukemia (AMML) 1. Hodgkin Lymphoma
3. Juvenile Myelomonocytic Leukemia (JMML) 2. Non-hodgkin lymphoma
4. MDS/MPN with Sideroblasts a. Small lymphocytic lymphoma
b. Follicular lymphoma
III. MYELOPROLIFERATIVE NEOPLASMS (MPN) c. Mantle cell lymphoma
d. Diffuse Large B-cell lymphoma
1. Chronic Myelogenous Leukemia (CML)/Chronic e. Burkitt lymphoma
Granulocytic Leukemia (CGL) f. Lymphoblastic lymphoma
a. Juvenile CML g. Anaplastic large cell lymphoma
2. Chronic Neutophilic Leukemia (CNL) h. Peripheral T/NK cell Lymphoma
3. Polycythemia Vera 3. Mycosis Fungoides/Sezary’s syndrome/cutaneous T
4. Essential Thrombocythemia cell lymphoma
5. Primary Myelofibrosis (PMF)/Agnogenic Myeloid
Metaplasia (AMM) VIII. PLASMA CELL DYSCRASIA (Paraproteneima)
6. Chronic Eosinophilic Leukemia 1. Plasma Cell neoplasms
7. Myeloproliferative Neoplasm, Unclassifiable (MPN-U) 2. Multiple Myeloma
8. Mastocytosis (previously categorized under MPN) 3. Plasma Cell Leukemia
4. Waldenstorm’s Macroglobulinemia
IV. ACUTE MYELOPROLIFERATIVE DISORDERS (AML) 5. Heavy chain disease
6. Amyloidosis
1. FAB Classification
a. M0 – Acute Myeloblastic Leukemia with minimal
Differentiation
b. M1 – Acute Myeloblastic Leukemia without
Maturation
c. M2 – Acute Myeloblastic Leukemia with
Maturation
d. M3 – Hypergranular Promyelocytic Leukemia
 M3m – Microgranular Promyelocyci
Leukemia
e. M4 – Acute Myelomonocytic Leukemia (Naegli
Monocytic Leukemia)
 M4e
f. M5 – Acute Monocytic Leukemia (Schilling
Leukemia)
 M5a
 M5b
g. M6 – Erythroleukemia (DiGuglielmo’s syndrome)