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Osteosarcoma occurs mainly in the metaphysic of the long bones. Most tumors arise in
bones involved with the knee joint at the distal end of the femur or proximal distal end of
of osteiod tissue. The tumor borders are distinct and merge into adjacent normal bone.
(male),Family history, Teenage growth spurt, Tall for age, Previous treatment with
disturbance.
Once there is mutation of tha DNA,it activates the oncogene which leads to a
deactivation of the suppressor gene which causes a malignant osteoblast that leads to
overcrowding of the bone. There is then suppression of red bone marrow which leads to
causes pressure inside the bone which is a main cause of pain and fractures.
The cancer then metastasizes spreading to other parts of the body especially the
Malignant osteoblast
Increased pressure
inside bone
Intense Spasm
inflammatory
response
pressure/irritation
Pain
of nerve endings
angiogenesis
Administer
analgesics
CONCLUSION
has already metastasized and most commonly into the lungs. Patients are either
doing some of the following: provide quiet environment and calm activities to prevent or
lessen pain, Provide comfort measure such as back rub, change position and use of
indicated to maximal dose as needed, Encourage the patient to increase fluid intake,
Encourage rest periods to prevent fatigue, Provide accurate information about the
situation, medication and treatment, Assess muscle strength, gross and fine motor
This study gives us information and knowledge about the Osteosarcoma and way on
how to deal with these kinds of patients. Proper management and treatment and
specially ensuring that the patient is kept comfortable and that he receives support and
understanding.