OTC Heartburn Remedy Comparison Chart

Proton Pump
Inhibitors/PPIs1
(such as PRILOSEC OTC®) H2 Blockers2 Antacids2

What It Does Most effectively reduces

acid production at its source
Partially reduces acid
production at its source
Neutralizes existing acid,
but doesn’t reduce acid
production at its source

How Long It Works Starts working on Day 1*;

Some people get complete
30-60 minutes Immediately

relief within 25 hours

*May take 1 to 4 days for full effect. Not for immediate relief.

How Long It Works 24 hours with one pill a day Up to 12 hours with one pill 20-30 minutes; Up to 3
hours if taken within 1 hour
after a meal

Use as directed for frequent heartburn for 14 days.

1

Use each product as directed.

2