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Замещение
Связывание
ГДФ
Ф α β γ Ф агониста Ф α β γ Ф на ГТФ Ф α β γ Ф
Рекомбинация
α- и βγ-субъединиц ГДФ
с трансмембранным
рецептором Диссоциация
ГТФ
Ф Ф гидролиз Ф Ф
α γ α γ
β β
ГТФ
ГДФ
Fig. 1.3 The functioning of G-protein subunits. Ligand (agonist) binding results in replacement of GDP on the α-subunit by
guanosine triphosphate (GTP) and the dissociation of the α- and βγ-subunits, each of which can affect a range of intracellular
systems (shown as E in the figure) such as second messengers (e.g. adenylyl cyclase and phospholipase C), or other enzymes
and ion channels (see Figs 1.4 and 1.5). Hydrolysis of GTP to GDP inactivates the α-subunit, which then recombines with the
βγ-dimer to reform the inactive receptor.