INDIAN JOURNAL OF MEDICAL & PAEDIATRIC ONCOLOGY Vol.

29 No 1, 2008 71

Multiple choice questions

1. Which of the following chemotherapy drug 7. On immunohistochemistry, classical

is likely to be toxic to gonads? Hodgkin’s lymphoma Reed sternberg cells
a. Adriamycin are likely to be
b. Vinblastine a. CD15(-), CD 30(+),CD45(-)
b. CD15(+), CD 30(+),CD45(+)
c. Paclitaxel
c. CD15(+), CD 30(+),CD45(-)
d. Procarbazine
d. CD15(-), CD 30(+),CD45(+)
2. High dose chemotherapy given prior to 8. For children with β-thalassemia, the
stem cell transplant may be associated with transplant outcome is likely to be best in
gonadal failure. Risk is least with the use of which subgroup?
a. Busulfan + cyclophosphamide a. Hepatomegaly
b. Cyclophosphamide + TBI b. Liver fibrosis
c. Ifosfamide +carboplatin+ Etoposide c. Inadequate iron chelation
d. Fludarabine + ATG d. Absence of above factors
3. Incidence of Gallbladder cancer is highest 9. For allogenic hemopoietic stem cell
in transplantation in children with
hemoglobinopathies. Presently best source
a. Chile of stem cells is
b. India a. Bone marrow
c. United Kingdom b. umbilical cord
d. South Africa c. peripheral blood
4. Which of the following is least to occur as d. bone marrow +peripheral blood
Gallbladder primary? 10. Involvement of which of the following
a. Adenocarcinoma organ is likely to be associated with poor
outcome in primary amyloidosis
b. Squamous cell carcinoma
a. cardiac
c. Lymphoma b. renal
d. Carcinoid tumour c. skin
5. Which of the following is less likely to be d. liver
associated with Gallbladder cancer? 11. Most common site of metastasis in breast
a. Obesity cancer is
b. Use of tobacco and alcohol a. lung
c. Aflotoxins b. liver
c. bone
d. Past history of enteric fever
d. brain
6. Most common subtype of Hodgkin’s
12. Which one of the following cancers is
lymphoma seen in children in India is
usually associated with a moderate to high
a. Nodular sclerosis uptake of 18 F-fluorodeoxyglucose ( 18 F-
b. Mixed cellularity FDG)?
c. Nodular lymphocytic predominant a. Bladder
hodgkins lymphoma (NLPHL) b. Colorectal
d. Lymphocyte rich classical Hodgkin’s c. Thyroid
lymphoma (LRCHL) d. Testicular
INDIAN JOURNAL OF MEDICAL & PAEDIATRIC ONCOLOGY
13. Which one of the following is an accurate
definition of the sensitivity of a screening
test?
a. The percentage of screening tests that
are positive
b. The percentage of screening tests that
are negative among patients who
remain unaffected by the condition of
interest after screening
c. The percentage of screening tests that
are positive among patients who
remain unaffected by the condition of
interest after screening
d. The probability of a diagnosis of the
condition of interest after a positive
screening test
Answers
1. d, 2. d, 3. a , 4. c 5. c, 6. b, 7. c, 8. d
Vol. 29 No 1, 2008 72
14. Epstein-Barr virus-associated Hodgkin’s
lymphoma is …
a. common in the elderly
b. common in young children
c. more common in industrialized
countries
d. more common in females
15. T reatment of early stage favorable
Hodgkin’s lymphoma …
a. necessarily includes radiotherapy
b. requires 6 to 8 cycles of multiagent
chemotherapy
c. with 4 cycles of chemotherapy and low-
dose involved-filed radiotherapy is the
standard of care
d. with complete response to 2
chemotherapy cycles further treatment
is not needed.
9. a, 10. a 11. c, 12. b. 13. c 14. b 15. c