Approved at the June 14, 2019 meeting of the USAN Council

New stems
Stem Definition Examples
-corilant glucocorticoid receptor antagonists relacorilant
(not glucocorticoids)
-ef- Fc region is present Pegefinodutide
-fungerp Antifungals, triterpinoids ibrexafungerp
-coplan1 Complement ligand inhibitors zilucoplan
-plenib Spleen tyrosine kinase (Syk) Lanraplenib,
inhibitors entosplenib
-tide
-dutide Oxyntomodulin analogs pegefinodutide
-vivint Wnt (Wingless/Int-1) signaling lorcivivint
pathway inhibitor

1. Derived from and related to the -copan stem, for complement recdptor
antagonists/inhibitors

Revised stems (for harmonization with INN)

Old stem New stem Definition
-ixafor1 -xafor CXCR receptor antagonists
-tirome 2 -tirom ntihyperlipidemic, thyromimetic derivatives

1. Stem is being revised to broaden its definition to account for all types of
CXCR receptor antagonists, since there are many receptor subtypes.
2. -tirome is being modified to -tirom to distance the stem from -terone.

Revised definitions
Stem Old Definition New Definition
-cept Receptor molecules Receptor molecules or membrane
or membrane ligands, ligands, natural or modified
natural, modified or
synthetic
-cirnon1 Chemokine receptor 9 Chemokine receptor (CCR)
(CCR9) antagonists antagonists, not antivirals
-viroc1 Antivirals, CCR5 Antivirals, chemokine receptor
antagonists (CCR) antagonists

1. Revision is being made so stem can be applied to all subtypes of CCR

receptor.
Harmonization of Definitions with INN
Stem INN Definition USAN Definition
None

Radicals and Anions

Modifier Chemical Name Structure
Choline 2-hydroxy-N,N,N- HO
+
N
trimethylethanaminium
Malate 2-hydroxysuccinate or 2- O
hydroxysuccinic acid HO
OH

O OH