TABLET ASETOSAL LEPAS LAMBAT

Konsentrasi Abs KURVA KALIBRASI ASESOTAL

0.7
80 0.299
100 0.6
0.398 f(x) = 0.003675x + 0.017
120 0.462 R² = 0.9932432432
0.5
140 0.531
160 0.600 0.4
Abs

0.3

0.2

0.1

0
70 80 90 100 110 120 130 140 150 160 170
Konsentrasi

DISOLUSI TABLET ASETOSAL LEPAS LAMBAT

Waktu A B C D E F
10' 0.037 0.040 0.032 0.038 0.030 0.033
15' 0.042 0.045 0.038 0.046 0.043 0.043
30' 0.080 0.064 0.070 0.065 0.055 0.054
60' 0.169 0.117 0.148 0.127 0.136 0.113
90' 0.246 0.185 0.207 0.235 0.251 0.218
120' 0.354 0.247 0.294 0.306 0.337 0.343
180' 0.483 0.344 0.457 0.415 0.458 0.483
240' 0.624 0.436 0.572 0.540 0.549 0.590
300' 0.677 0.534 0.633 0.637 0.624 0.645
360' 0.700 0.649 0.684 0.712 0.659 0.667

KURVA DISOLUSI
ABSORBAN TERHADAP WAKTU
0.8
0.7
A
0.6
B
0.5 C
0.4 D
Abs

0.3 E
F
0.2
0.1
0
0 2 4 6 8 10 12
Waktu (Menit)
Hasil Disolusi Tablet Lepas Lambat Asetosal Formula 1

Berat Asetosal Berat Asetosal Asetosal

Bejana Waktu Terlarut Tanpa Terlarut Setelah Ditambah Terlarut (%)
Faktor Koreksi (mg) Faktor Koreksi (mg)

10' 4.860 3,037%

15' 6.081 6.135 3,804%
30' 15.324 15.392 9,620%
60' 36.972 37.143 23,214%
90' 55.703 56.115 35,071%
A
120' 81.972 82.595 51,621%
180' 113.351 114.269 71,418%
240' 147.648 148.917 93,073%
300' 160.540 162.194 101,371%
360' 166.135 167.937 104,960%
10' 5.594 3,496%
15' 6.810 6.872 4,295%
30' 11.431 11.507 7,919%
60' 24.324 24.451 15,281%
90' 40.864 41.135 25,709%
B
120' 55.945 56.402 35,251%
180' 79.540 80.167 50,104%
240' 101.918 102.808 64,255%
300' 125.757 126.899 79,311%
360' 153.196 155.196 96,997%
10' 3.648 2,280%
15' 5.107 5.147 3,216%
30' 12.891 12.948 8,092%
60' 31.864 32.007 20,004%
90' 46.216 46.571 29,107%
C
120' 67.377 67.894 42,433%
180' 105.810 106.564 66,602%
240' 135.243 136.427 85,266%
300' 149.838 151.354 94,596%
360' 162.243 163.924 102,452%
10' 5.108 3,192%
15' 7.054 7.111 4,444%
30' 11.676 11.756 7,347%
60' 26.757 26.888 16,805%
90' 53.027 53.326 33,329%
D
120' 70.267 70.889 44,306%
180' 96.810 97.598 60,999%
240' 127.216 128.300 80,181%
300' 149.594 151.019 94,386%
360' 169.054 170.732 106,707%
 10' 3.162 1,976%
15' 6.324 6.359 3,974%
30' 9.243 9.314 5,821%
60' 28.946 29.049 18,156%
90' 56.919 57.242 35,776%
E
120' 77.878 78.514 49,071%
180' 107.270 107.813 67,383%
240' 129.406 130.604 81,627%
300' 147.649 149.100 93,187%
360' 164.054 165.710 103,569%
10' 3.891 2,431%
15' 6.324 6.351 3,964%
30' 9.000 9.070 56,69%
60' 23.351 23.451 14,565%
90' 48.892 49.152 30,720%
F
120' 79.297 79.843 49,901%
180' 113.351 114.238 71,399%
240' 139.378 140.647 87,904%
300' 152.757 154.319 96,440%
360' 158.108 159.823 99,890%
 0.1
0
0 2 4 6 8 10 12
Waktu (Menit)

Asetosal Terlarut (%Q)

Waktu
A B C D E F Rata-Rata
10' 3.037 3.496 2.280 3.192 1.976 2.431 2.735
15' 3.804 4.295 3.216 4.444 3.974 3.964 3.950
30' 9.620 7.919 8.092 7.347 5.821 5.669 7.411
60' 23.214 15.281 20.004 16.805 18.156 14.565 18.004
90' 35.071 25.709 29.107 33.329 35.776 30.720 31.619
120' 51.621 35.251 42.433 44.306 49.071 49.901 45.431
180' 71.418 50.104 66.602 60.999 67.383 71.399 64.651
240' 93.073 64.255 85.266 80.181 81.627 87.904 82.051
300 101.371 79.311 94.596 94.386 93.187 96.440 93.215
360 104.960 96.997 102.452 106.707 103.569 99.890 102.429

PROFIL DISOLUSI TABLET ASETOSAL LEPAS LAMBAT

FORMULA 1
120

100 A
80 B
C
60 D
%Q

E
40
F
20

0
290 300 310 320 330 340 350 360 370
Waktu
 Rata-Rata %Q
Waktu
Formula 1 Formula 2
10' 2.735 22.917
15' 3.950 35.026
30' 7.411 54.010
60' 18.004 69.797
90' 31.619 75.783
120' 45.431 79.897
180' 64.651 81.486
240' 82.051 83.445
300' 93.215 85.350
360' 102.429 87.256

PROFIL DISOLUSI RATA-RATA

TABLET ASETOSAL LEPAS LAMBAT
FORMULA 1 DAN FORMULA 2
120

100

80 F1
F2
60
%Q

40

20

0
0 2 4 6 8 10 12
Waktu
 TABLET ASETOSAL LEPAS LAMBAT

KURVA KALIBRASI TABLET ASESOTAL

Konsentrasi Abs
0.7

80 0.6
0.315 f(x) = 0.003675x + 0.017
100 0.399 R² = 0.9932432432
0.5
120 0.472
140 0.531 0.4
160
ABS

0.600
0.3

0.2

0.1

0
70 80 90 100 110 120 130 140 150 160 170
Konsentrasi

DISOLUSI TABLET ASETOSAL LEPAS LAMBAT

Waktu A B C D E F
10' 0.119 0.120 0.159 0.140 0.181 0.197
15' 0.192 0.180 0.209 0.203 0.259 0.295
30' 0.304 0.281 0.310 0.310 0.385 0.418
60' 0.397 0.367 0.393 0.389 0.491 0.525
90' 0.427 0.410 0.426 0.423 0.531 0.552
120' 0.468 0.428 0.449 0.447 0.542 0.579
180' 0.472 0.445 0.450 0.458 0.556 0.587
240' 0.473 0.451 0.467 0.468 0.572 0.606
300' 0.481 0.460 0.472 0.472 0.593 0.626
360' 0.488 0.475 0.489 0.489 0.603 0.627

KURVA DISOLUSI TABLET ASETOSAL F2

ABSORBANSI TERHADAP WAKTU
0.700
0.600
0.500
0.400
0.300
0.200
0.100
0.000
10' 15' 30' 60' 90' 120' 180' 240' 300' 360'
A B C D E F
0.400
0.300
0.200
0.100
0.000
10' 15' 30' 60' 90' 120' 180' 240' 300' 360'
A B C D E F
 Berat Asetosal Berat Asetosal Asetosal
Waktu Terlarut Terlarut
Bejana Serapan Terlarut
(menit) Sebelum Ditambah Setelah Ditambah (%Q)
Faktor Koreksi (mg) Faktor Koreksi (mg)
10 0.119 27.568 17.230
15 0.192 47.297 47.573 29.733
30 0.304 77.568 78.044 48.778
60 0.397 102.703 103.483 64.677
90 0.427 110.811 111.846 69.904
A
120 0.468 121.892 123.010 76.881
180 0.472 122.973 124.203 77.627
240 0.473 123.243 124.485 77.803
300 0.481 125.405 126.650 79.156
360 0.488 127.297 128.563 80.352
10 0.120 27.838 17.398
15 0.180 44.054 44.332 27.708
30 0.281 71.351 71.794 44.871
60 0.367 94.594 95.312 59.570
90 0.410 106.216 107.169 66.981
B
120 0.428 111.081 112.153 70.096
180 0.445 115.676 116.797 72.998
240 0.451 117.297 118.465 74.041
300 0.460 119.730 120.915 75.572
360 0.475 123.784 124.993 78.121
10 0.159 38.378 23.986
15 0.209 51.892 52.276 32.673
30 0.310 79.189 79.712 49.82
60 0.393 101.622 102.419 64.012
90 0.426 110.541 111.565 69.728
C
120 0.449 116.757 117.873 73.671
180 0.450 117.027 118.206 73.879
240 0.467 121.622 122.804 76.753
300 0.472 122.973 124.201 77.626
360 0.489 127.568 128.810 80.506
10 0.140 33.243 20.777
15 0.203 50.270 50.602 31.626
30 0.310 79.189 79.695 49.809
60 0.389 100.541 101.338 63.336
90 0.423 109.730 110.743 69.214
D
120 0.447 116.216 117.323 73.327
180 0.458 119.189 120.362 75.226
240 0.468 121.892 123.096 76.935
D

300 0.472 122.973 124.204 77.628

360 0.489 127.568 128.810 80.506
10 0.181 44.324 27.703
15 0.259 65.405 65.848 41.155
30 0.385 99.459 100.117 62.573
60 0.491 128.108 129.109 80.693
90 0.531 138.919 140.210 87.631
E
120 0.542 141.892 143.294 89.559
180 0.556 145.676 147.109 91.943
240 0.572 150.000 151.471 94.669
300 0.593 155.676 157.191 98.244
360 0.603 158.378 159.950 99.969
10 0.197 48.649 30.406
15 0.295 75.135 75.621 47.263
30 0.418 108.378 109.134 68.209
60 0.525 137.297 138.388 86.493
90 0.552 144.595 145.979 91.237
F
120 0.579 151.892 153.352 95.845
180 0.587 154.054 155.588 97.243
240 0.606 159.189 160.745 100.466
300 0.626 164.595 166.202 103.876
360 0.627 164.865 166.527 104.079
 %Q

Waktu Rata-Rata
A B C D E F

10 17.230 17.398 23.986 20.777 27.703 30.406 22.917

15 29.733 27.708 32.673 31.626 41.155 47.263 35.026
30 48.778 44.871 49.82 49.809 62.573 68.209 54.010
60 64.677 59.570 64.012 63.336 80.693 86.493 69.797
90 69.904 66.981 69.728 69.214 87.631 91.237 75.783
120 76.881 70.096 73.671 73.327 89.559 95.845 79.897
180 77.627 72.998 73.879 75.226 91.943 97.243 81.486
240 77.803 74.041 76.753 76.935 94.669 100.466 83.445
300 79.156 75.572 77.626 77.628 98.244 103.876 85.350
360 80.352 78.121 80.506 80.506 99.969 104.079 87.256

Profil Disolusi Asetosal F2

120

100
A
80 B
C
60
Abs

D
40 E
F
20

0
0 50 100 150 200 250 300 350 400
Konsentrasi