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Stress Diabetes

Age
Oxygenation - Great impact on - Diabetic individuals
- Increased age is a human health exhibit a
- Important for cell metabolisme, major risk factor - Induced documented
- Prevent wound from infection for impaired disruption of impairment in the
- Induces angiogenesis wound healing healing of acute
neuroendocrine
- Increase keratinocyte - In healthy adults, immune wounds
differentiation, migration, and the effect of - All diabetes related
equilibrium is
re-epithelialization aging causes a consequential to lower leg
- Enhances fibroblast proliferation temporal delayed health amputation.
and collagen synthesis in wound healing
- Promotes wound contraction
Obesity Sex Hormones
- Obese individually - Aged mates have been
Systemic frequently face wound shown to have delayed
Local Factors Factors complications, include healing of acute wounds.
skin wound infection,
- Female estrogens, male
dehiscene, hematoma
Infection androgens and their
and seroma formation,
pressure ulcer and steroid precursor DHEA
- Contamination FACTOR AFFECTING venous ulcer appear to have significant
- Colonization WOUND HEALING - Obesity well-known to effects on the wound-
- Local infection/ critical
increase risk of disease healing process.
colonisation
and health conditions
- Invasive infection
- Inflammation is a normal
part of the wound-healing Alcohol Consumpation
process to removal of Smoking ( show a delay in Medication
- Acute ethanol exposure can
microorganisms Nutrition wound healing and an increase lead to impaired wound healing - Glucocorticoid
in a variety of complications) by impairing the early
inflammatory responses,
steroids
- Fats and carbo are the
Substances in cigarettes: inhibiting wound closure, - Non-steroidal anti-
primary source of energy
angiogenesis, and collagen inflammatory
in the wound healing
- Nicotine: decreased production, and altering the - Chemotherapeutic
process protease balances at the wound
- Glucose is provide energy
tissue blood flow, drugs
side
- Protein is important for increase blood viscosity
- The host respondes to choronic
nutrient factors affecting - Carbon monoxide: alcohol exposure appears to be
wound healing and effect decreased fraction of different from that of acute
immune system oxygenated hemoglobin alcohol exposure
- Vitamins has multiple - Choronic alcohol exposure
- Hydrogen cyanide:
causes impaired wound healing
effect on tissue repair compromised oxygen and enhanced host
consumption in tissue susceptibility to infections.

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