Comparison between different GFR

indicators

AbdelRahman Omar
ID: 1710184

4/12/2020
 Indicator used for measuring Glomerular Filtration Rate

Inulin Creatinine Urea

Advantages  It is the most accurate  Endogenous compound can  Its plasma

indicator for GFR because
it is filtered by the
glomerulus and does not
undergo reabsorption or
secretion in the tubules of
the nephron.
 Its clearance is equal to
the GFR of the kidney.
Disadvantages  Exogenous compound
that is found in plants, do
it needs to be given to
patient through a viable
administration route.
 Its clearance is normally
measured by infusing it to
patients intravascularly for
a period of time, which
makes it invasive and
undesired in clinical
practice.
constantly be found in concentration in
certain limits in humans, so it normal conditions
can be measured from blood is used as a
directly without the need for reference for
invasive procedures. function of
glomerulus.
 It can be measured from a
24-hour urine collection  Readily available
which gives another option in the body and
for measurement. does not require
invasive
procedure.
 Exogenous intake of  Renal disorders
creatinine through diet can can cause an
cause minor changes in its increase in urea
excretion. concentration in
the plasma.
 Not as accurate as inulin and  Less accurate than
its clearance is greater by 7% creatinine because
because it goes through many factors can
secretion and reabsorption affect it.
processes.
 Protein-rich diet
 It’s not accurate in patients can affect plasma
with low GFR that’s less than concentration of
10ml /min because it urea in a major
overestimated and should way and its
not be used in patients with excretion.
advanced chronic kidney
disease (CKD).  It can also be
affected by
dehydration,
treatment with
cortisol, and
muscle wasting.