C6 metabolism Glucose metabolism and central pathways C5 metabolism C4 metabolism C3 metabolism C2 metabolism Metabolism of aromatics Inorganic metabolism

GLe GLYNe LLACe LACe PROPe PROPALe ACe ACALe ETHe PHPYRe PHALe PHACe 3HBAe PCCe COUMe LMANDe DMANDe BNe BAe BAMNe INDe TRPe ANe SALIe RESe DMTe TPHTHe DHSKe VANe FERe UREAe HNO3e NH3e H2SO3e CHOSLFe SLFe
GALUNTe GALNTe GLACe GALOLe IDOLe SORe SOTe MANe MNTe FRUe RHAe GLCNTe GLCN15LACe bDGLCe DGLCe GLCe TANAe RIBe RIBOLe RLe ARABe AOLe XYLe XULe XOLe LXULe LAOLe LARABe EUe EOLe Ee TARe
H2Oe H2O2e O2e
10 345THBe 10 H2Oe

DGLC AMP
PI
NADP NADPH H2O2 O2 NAD NADH
CO2 H2O ATP PPI
ATP
MNT FRU RHA NADP COA
GALOL IDOL SOR SOT MAN GLCNT GLCN15LAC bDGLC GLC RIB RIBOL ARABLAC ARAB LAOL LARAB EU EOL E TAR OXGLY G LLAC PROP PROPAL AC ACAL ETH PHPYR IND TRP DMT FER UREA HNO3 NH3 H2SO3 H2SO3 H2SO3 PAP CHOSLF SLF APS
GALUNT PI GLYAL GL GLYN AMP 2 NH3
NADP NADPH ATP NADPH ATP
NAD ATP ATP ATP ATP ATP r125 O2 H2O
ATP NADP H2O2 O2 NADPH NAD OTHIO
NADH NAD NADH NAD NADPH NADP NADPH NADP NADP NADPH ATP O2 COA CO2 NADPH 3 NADPH
ATP NADPH ATP NADH NAD NAD NADH NADP NAD ATP
H2O NAD NADH NADPH NADP NADP NADPH NADH NAD NADH NAD
ADP NADH ADP ADP H2O ADP ADP NAD H2O
NADPH ADP ATP H2O ATP
ADP METHOL
NADPH NADP NADP NADH H2O CO2 AMP
PI D6PGL D6PGC NADP
GALUNTP GALN14LAC GLAC FRU MAN6P MNT1P F6P RHAMN bDG6P G6P To Ox at COA NADP 3 NADP O2
ADP
KDDGC R5P RL ADP H2O NADPH NADH 3HIND FKYN MTPHTH AMP
UTP H2O ATP Nucleotide sugars NAD NADH ATP ATP ADP H2O NADP NADPH H2O NADP
NADH AOL LXUL
EU1P E4P OA
ADP mitochondrion ACCOA PHAL ADP H2O 3 H2O H2O
RTHIO
NADH NAD

r1
ADP GL3P 3HPYR PYR O2 H2O FERCOA

1
NADPH H2O PI HNO2 H2S S PAPS CHO PAPS

47
NADH NADPH H2O NAD H2O
PPI ADP H2O
ATP
ADP D6PGC To Mitochondrion UREAC
UDPGALU GALNT GAL1P G1P G6P MAN1P H2O ADP F6P 3 NADPH
GLYAL PYR NAD NADP NADP NADPH O2 H2O NADP FOR METHOL
2 NADH GTP RHAMNP NADP PI ATP
Pyrimidine
CO2
RL5P ADP NADH
UTP UTP F26P NADPH R1P
metabolism To HIS biosynthesis XUL5P XUL XOL T3P1 FALD To Ox at To TCA NFAN KYN TPHTH
PHAC 4HPAC FERHCOA
2 NAD H2O ADP mitochondrion 3 NADP
PPI PPI 2 CO2
H2O
UDP
PPI
NADPH
RL5P ADP ATP NADH
O2
H2O
NADPH
H2O2e
LACAL T3P2 FDP FALD NAD H2O 3 H2O
2D3DGALT UDPGAL UDPG GDPMAN DPDGC
NADPH O2
UDPGAL NAD NADH
AMP ATP
NADP 2 NH3 NH4OH
T3P1 GLYN ALA METHOL
UDP H2O
TRE6P PRPP R5P XUL5P T3P1 NADP FOR NADP CO2e
GLYAL PYR H2O GL3P T3P2 T3P1 NADPH 4HMAND AN VANIN
XYL 2HPAC
Di-tetrasaccharide metabolism 13GLUCAN 14GLUCAN
PI
PI
NAD O2
NADPH DHCHDDC NAD
OH
H2O O2 H2O
Export/ PI NADP NAD
NADP
TRE T3P1 S7P NADPH
NIG PSNIG import NADH H2Oe
Purine PI NH3
NADPH NADH
13PDG metabolism PRCP CO2 H2O O2 NADP
H2O
H2O
RGT PI Fatty acid catabolism Fatty acid catabolism NADP
NADPH NADH
NH3 CO2
H2Oe MTHGXL ADP
SALI VAN
2 DGLC F6P E4P F6P GNTAL HOMOGEN 4HPP 4HBFOR COUM DMAND LMAND DHBA PCC O2e
2 GLCe MLTe MLT 2 GLC NADPH H2O

3PG
ATP
Even number of carbons Odd number of carbons O2
O2
O2 NAD
NAD NADPH
CO2 O2
NADP H2O O2
PI FALD H2O NADP NADPH O2 CO2
GLACe GLAC To biomass
CO2 NADH CO2 PIe
H2Oe H2O LGT LACAL AC NADH
R1P H2O2 MACAC 4HBAL BN BFOR CCL GUA
LACT
NAD 2PG
LACTe GEN
H2O

NAD H2O
H2O H2O NADP NADPH O2
GLCe GLC NADH
O2 NADH NAD O2
H2O C120COA C140COA C160COA C180COA C200COA C150COA C170COA C190COA NADH
RGT LAC From C2 metabolism NH3 CO2 BTOL RES
PEP ACAL CAR CAR CAR CAR CAR CAR CAR CAR
FUACAC 4HBA BA BAL O2
ADP MUCO
H2O O2
TREe TRE COA COA COA COA COA COA COA COA 3MPYR H2O NADP O2 H2O2
GLACe ATP CO2
H2O
NADPH
H2Oe NAD NADPH NADPH NADP NH3
C120CAR CAR C140CAR CAR C160CAR CAR C180CAR CAR C200CAR CAR C150CAR CAR C170CAR CAR C190CAR CAR
PYR ACTP AC ACAL ETH 3OA H2O NH3 CO2 O2 PI
MELIe NADP
NADH
ACTAC 2MAC
H2O
GLCe
O2 H2O CO2 ADP ATP 3HBA PCC MUCL
3FPYR ATP O2
NADPH
COA
H2O O2 NADPH NADP H2O BAMN
GLACe ADP H2O
H2Oe O2 NADP
PI
STACe COAm FUM PYR 3CMUCO 4CMUCL OAEL 3OA To Mitochondrion
ATPm AACCOA
NADm COAm

RAFFe GLACe PYRm CO2m ACm ACALm ETHm 3OAm H2Om NH3m CO2m O2m PIm C120CARm CARm C140CARm CARm C160CARm CARm C180CARm CARm C200CARm CARm C150CARm CARm C170CARm CARm C190CARm CARm
AMPm CO2
PEP PYR
NADHm SUCCOAm COAm COAm COAm COAm COAm COAm COAm COAm
SUCe NADHm NADm NADHm NADm
CO2
CARm CARm CARm CARm CARm CARm CARm CARm
GLCe COAm SUCCm
CO2 ATP
PYR C40COAm C60COAm C80COAm C100COAm C120COAm C140COAm C160COAm C180COAm C200COAm C50COAm C70COAm C90COAm C110COAm C130COAm C150COAm C170COAm C190COAm
To C1 ACCOAm 3OACOAm FADm FADm FADm FADm FADm FADm FADm FADm FADm FADm FADm FADm FADm FADm FADm FADm FADm
FRUe AC H2O ADP NADPH
H2Om
metabolism NADPHm
ADP NADH CO2 COAm FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m FADH2m
NADHm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm

ACCOAm
CO2m ADPm
OXAL OA ATP NAD NADm C4DCOAm C6DCOAm C8DCOAm C10DCOAm C12DCOAm C14DCOAm C16DCOAm C18DCOAm C20DCOAm C5DCOAm C7DCOAm C9DCOAm C11DCOAm C13DCOAm C15DCOAm C17DCOAm C19DCOAm
OA OAm
C1 metabolism To export NADP NADPm
ATPm
SUCCOAm H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om H2Om
COAm
transporter CIT ADP
MAL MALm CITm COA ACCOAm
METHOLe METHOL ACCOA ACm

COAm

COAm

COAm

COAm

COAm

COAm

COAm

COAm

COAm
ATPm AMPm
NAD COA ATP
ASPm PPIm C4HCOAm C6HCOAm C8HCOAm C10HCOAm C12HCOAm C14HCOAm C16HCOAm C18HCOAm C20HCOAm C5HCOAm C7HCOAm C9HCOAm C11HCOAm C13HCOAm C15HCOAm O2 C17HCOAm C19HCOAm
To export

COAm

COAm

COAm

COAm

COAm

COAm
NADH
transporter H2Om
NADm NADm NADm NADm NADm NADm NADm NADm NADm NADm NADm NADm NADm NADm NADm NADm NADm
QTe
H2Om
H2O
FALD FGT ACCOAm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm NADHm
FUM FUMm H2Om ACOm
GLXm
Acid transporters NAD
TCA cycle
CITRm ARGSUCCm AACCOAm
COAm
C6OCOAm C8OCOAm C10OCOAm C12OCOAm C14OCOAm C16OCOAm C18OCOAm C20OCOAm C5OCOAm C7OCOAm C9OCOAm C11OCOAm C13OCOAm C15OCOAm C17OCOAm C19OCOAm

NADH
RGT NAD NADH
FADH2m FADH2m
H2Om
COAm
AA biosynthesis SMEe
PIm
H2O ACCOAm
Glyoxylate shunt
OXAL
From OA FADm Urea cycle 2 ACCOAm PROPm PROPCOAm
FORe FOR
degradation FADm
CO2m AKGm MAL Glycine, GLYe
GLUm CAPm Glutamate,

QH2m

Qm
SUCCm NADm ICITm FUMm ATPm COAm AMPm PPIm H20m
Proline Methionine Cysteine Homoserine Serine, Aromatic AA Histidine
O2
ICIT SUCC SUCCSALm GABAm Branched amino acids Alanine and aspartate
CO2 To export NADHm NADm NADPm
UREAm H2Om OAm
AKG Glutamine Threonine
CO2
H2O2
transporter
GTPm
COAm
CO2m
NADHm
ORNm ARGm (Valine, leucine, isoleucine) conversions Lysine
MALm
ASPm GLU
NADP
GABA shunt ALAe
AKG GLUm GLUm OAm ACCOAm AKGm
CO2 2 PYRm THRm PYRm COAm
CO2
SUCCOAm AKGm GLUm ASP
NADPH To export H2Om
E4P PEP
GDPm CO2m
COAm ACCOAm 2MCITm AKG GLU ASP 3PG PRPP
NADPHm transporter THRm bALAe
THR NADH
ATP NAD ATP
COAm NH3 NH3
CO2m NH3m
MAL ACOm COAm NAORNm NAGLUm GLUm HCITm
OXALe OXAL NADHm
H2Om NADPH NADH PI
CO2m NADm ALAm AKGm ASPm ADP
ACLACm OBUTm ARGm ARG
NADH PPI
ATPm BASP PHP 3DDAH7P ARGe
ACO MALm NADPHm 2MACOm NADP NAD GLUGSAL PRBATP
ICITm Proline NADPH GLU
MALe MAL MAL GLU H2O
ASPm ASP
GLUm ADPm CO2m conversions HACNm
H2Om
NH3 NH3 PI ASNe
MALm NADPm
H2O AKG PI
ICIT ATP NAD NADP PPI
ABUTm PROm DQT QT
AKGe AKG NAGLUSm NAGLUPm DHVALm 2MICITm LEUm LEU P5C ASPSA 3PSER PRBAMP
2 H2O
AKG NADHm
AKGm NADPHm ADP NADPH NADH
NAD H2O
CYS biosynth. NADH ASPe
ACCOAm COAm
GLN NADH
COA ACCOA
ACOe ACO NADPm NADm HICITm ILEm ILE NADPH NADH
NH3 H2O
NADP
OA OAm NAD PI
NADPm NADPHm NADm PYRm SUCCm GLU PRO Protein synthesis SER DHSK
OIVALm IPPMALm DDHVAm GLUGSALm P5Cm OAHSER HSER PYR PRFP CYSe
ORNm NADPH NADH
NADm ORN NADP NAD ATP THF
SUCC SUCCm GLUm CO2m H2S
FUMe FUM NADPm NADHm
2 GLU GLX
THF MTHF ADN H2O
NADHm ACCOA METTHF NADP NAD
VALm VAL AC ADP ALA GLUe
FUM FUMm NADPHm NADm PHSER SME
AKGm NADHm MET HCYS SAH COA GLY PRLP
CITe CIT OXAm ASER ATP
GLUm GLUm ATP SER PYR GLN
VALm OICAPm OMVALm AC ACAL PYR
LYSm LYS NH3
GLNe
ICIT ICITm H2O SAH SAM NADH
GLUm GLUm Aspartate, Beta- alanine Alanine H2O H2O
ADP GLU
ICITe ICIT GLYm NAD SME3P AIRCAR
Asparagine PI LLCT PEP
GABA GABAm Energy metabolism AKAm THFm PPI THR OBUT DIMGP
THFm OA PYR SAM HISe
AKGm AKGm GLUm THF PI
NADm GLU AC
OAe OA NH3 NH3 NH3 NH3 NH3 PI
GLX GLXm LEUm ILEm NADPHm NADPm OBUT 3PSME
OTHIOm GTPm AMPm ITPm AMPm ADPm ADPm PPIm AKGm H2O2 GLU NADPH NADH
H2O
NADHm
ILEe
AMASAm SACPm METTHFm METTHF Protein synthesis CYS H2S Protein synthesis IMACP
NADPHm AMAm LYSm NH3m AKG NADP NAD
PYRe PYR H2O AKG ATP GLU
CITR CITRm CO2m O2
2 CYS
GLUm NADPm NADm NADHm ALA GLU PI
NADPHm AKGm ARG biosynthesis ASP bALA AC GLN CHOR LEUe
NADPm
NADHm NADm MTHFm METTHFm METHFm FTHFm FORm FOR O2 NAD AKG
SUCCe SUCC
CAP CAPm GLN PYR
NADPm NADPHm NADPm NADPHm H2Om CO2 ADP GLU HISOLP
ADPm ATPm ATP NADH
RTHIOm 2 PIm H2O2
GDPm ADPm IDPm ADPm AMPm ADPm
THFm THF LYSe
Protein synthesis NH3
CYST
GC Glutathione
GABAe GABA UREA UREAm AMP NADP
ATP
NAD
Protein synthesis
AN PHEN
GLU PI
3.88 H+POm K+m 3.88 H+POm Ca2+m GLY FOR GLY PRPP NADPH
FADH2m FADm NADHm NADm 0.5 O2m H2Om 4 H+POm 4 H+POm 3.88 H+POm
3.88 H POm
+
H POm
+
FADH2m FADm
ASN HISOL METe
4 H+POm NADH NAD
4 H POm
+
LLACm PYRm LACm PYRm ½ O2m H2Om ADPm ATPm ATPm ADPm ATPm ADPm ATPm ADPm ATPm ADPm PROPm CO2 2 NAD
Proton pump NH3
ADP PPI CO2
CO2
ATP H2O RGT NPRAN PHPYR 4HPP
H2O Qm Qm Qm Qm Qm Qm Qm Qm 2 FERIm 2 FERIm 2 FERIm 2 FERIm 2 FERIm
2 NADH PHEe
r235

Qm NADH
GLU GLU HIS
QH2m QH2m QH2m QH2m QH2m QH2m QH2m QH2m QH2m 2 FEROm 2 FEROm 2 FEROm 2 FEROm 2 FEROm
3.88 H+_e 3.88 H+ METTHF FTHF Degradation
AKG AKG
PROe
ADP NADPH NAD CO2
PI CPADSP PHE TYR
DOROA OROA NADH NADH NAD NADPH NAPD 4 H+PO NADPH NAPD 4 H+PO 3.88 H+PO
4 H+PO NAD 4 H+PO 3.88 H+PO 3.88 H+PO K+ 3.88 H+PO Ca2+ ADP H+PO ATP
GL3P PROP HISN
T3P2
COA
SERe
H2O
NADH CO2
NADPH NADP NADPH NADP 2 H2O
NADP ACCOA
From C3
IGP Protein synthesis
metabolism NAHISN THRe
OTHIO RTHIO O2 H2O2 2 H2O2 PPI 2 PI
MTHF METHF SER

O2
T3P1
TRPe
TRP

TYRe

VALe

Fatty acid synthesis CITRe

PROP
ATP

Pyrimidine metabolism Purine metabolism Even number of carbons COA Odd number of carbons
AMP
PPI
From
GLN CAP CAASP DOROA EMP PROPCOA
2 ATP GLU 2 ADP ASP PI ACP
O2
PRPP PRAM GAR FGAR FGAM AIR MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP COA
CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP MALACP CO2 ACP
OMP OROA
GLN GLU PPI GLY ATP PI ADP FTHF THF GLN ATP GLU ADP ATP ADP C40e
ATNe ATN ADP CBCCP ACCOA ACACP ACACP
PPI PRPP CO2

H2O2 ACP COA MALACP

PI
H2O AACACP C6OACP C8OACP C10OACP C12OACP C14OACP C16OACP C18OACP C20OACP C5OACP C7OACP C9OACP C11OACP C13OACP C15OACP C17OACP C19OACP C60e
CO2
PRFICA AICAR SAICAR CAIR NADPH NADPH
NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH
ATPe ATP NADPH NADPH NADPH
AMP ADP GDP GMP THF FTHF FUM ADP ASP ATP ATP BCCP MALCOA
ADP ATP H2O
RIB CO2 NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP
C80e
NADP NADP NADP
H2O ACP
UTP UDP UMP URI URA PPI AMP ADP C4HACP C6HACP C8HACP C10HACP C12HACP C14HACP C16HACP C18HACP C20HACP C5HACP C7HACP C9HACP C11HACP C13HACP C15HACP C17HACP C19HACP
NH3
GLN
ITP ACTAC C100e
H2Oe
RTHIO ATP cAMP IDP cGMP COA
ATP
ATP
cIMP
ADP ATP ADP ATP
H2O ADP ATP H2O H2O H2O H2O H2O H2O H2O H2O H2O H2O H2O H2O H2O H2O H2O
H2O AMP
cAMPe AMPe AMP DTHIO NH3
H2O H2O
COA
MALACP H2O H2O
C120e
PI
H2O PPI
PRPP C4DACP C6DACP C8DACP C10DACP C12DACP C14DACP C16DACP C18DACP C20DACP C5DACP C7DACP C9DACP C11DACP C13DACP C15DACP C17DACP C19DACP
PI
dUTP dUDP dUMP DU ADP ATP
FUM GDP ASP GTP ATP GLN H2O AMP GLU PPI ATP ADP PI NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH NADPH
NADPH NADPH NADPH
ADP ADP
XANe XAN PI DR1P GDP GTP ADP C140e
ADP ATP ADP ADP AMP ASUC IMP XMP GMP NADP NADP
PI NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP NADP
GLU NADP NADP
NH3
H2O RTHIO
PPI
H2O H2O NAD NADH H2O RTHIO AACCOA 2 ACCOA
ADP ADP ATP ADP
ADP C40ACP C60ACP C80ACP C100ACP C120ACP C140ACP C160ACP C180ACP C200ACP C50ACP C70ACP C90ACP C110ACP C130ACP C150ACP C170ACP C190ACP
H2O AMP ADP
PI
H2O
C141e
COA
PPI DTHIO NADH NADH NADH NADH NADH
URIe URI ADP ATP ADP ATP DTHIO
H2O NH3
PPI PPI PPI PI
H2O COA COA COA COA COA COA COA COA COA
COA
COA COA COA
ATP PI ATP PI ATP H2O H2O H2O H2O H2O O2 H2O O2 H2O O2 H2O H2O H2O O2 H2O O2
CTP CDP CMP CYTD CYTS dGDP dGTP
dATP dADP PRPP ADN INS GSN ACP C150e
H2O PI NAD NAD NAD NAD NAD
RTHIO H2O H2O ACP
URAe URA H2O GMP GDP
ADP PI
H2O
PI PI ADP ADP ATP ACP ACP ACP ACP ACP ACP ACP ACP C50COA ACP ACP ACP
ADP ATP NH3 PI PRPP PRPP PRPP ACP 2 H2O 2 H2O 2 H2O 2 H2O 2 H2O
ACP ACP ACP ACP ACP ACP ACP ACP ACP ACP ACP
H2O
DTHIO R1P NADH C160e
cCMP H2O R1P RIB R1P RIB R5P C40 C40COA C60 C60COA C80 C80COA C100 C100COA C120 C120COA C140 C140COA C141ACP C160 C160COA C161ACP C180 C180COA C181ACP C180 C180COA C150 C150COA C170 C170COA C171ACP C190 C190COA C191ACP
PI R5P ATP RIB NH3 R1P ATP
HYXNe HYXN H2O R1P COA COA COA COA COA COA COA COA COA COA COA COA
PPI AMP PPI AMP PPI AMP PPI AMP PPI AMP PPI AMP H2O COA PPI AMP H2O COA PPI AMP H2O COA PPI AMP PPI AMP PPI AMP H2O COA PPI AMP H2O COA
DC DG NADH
dCTP dCDP dCMP DA dAMP AD HYXN XAN GN dGMP NAD C161e
ATP ATP ATP ATP ATP ATP ATP ATP ATP ATP ATP ATP
ACP ACP ACP ACP ACP ACP COA ACP ACP ACP ACP
ADP ATP ADP ATP H2O NAD H2O NADH NAD PI NADH NADH NADH
PI NH3 H2O
ADe AD H2O NAD O2 O2 PENAL O2
METTHF
NH3 C141 C141COA C161 C161COA C181 C181COA C171 C171COA C191 C191COA C162e
DR1P COA
H2O2
PI NADH COA COA COA COA COA
BUTAL PPI AMP
NAD
PPI AMP
NAD
PPI AMP NH3 PPI AMP
NAD
PPI AMP

r2102
URIC 2 H2O 2 H2O 2 H2O
ADP ATP ADP ATP DIN DR1P H2O2
ATP ATP ATP ATP ATP C170e
DHF
PI
O2 H2O
dTTP dTDP dTMP NH3 C162ACP C182ACP C192ACP
DT THY H2O
NADH O2
H2O PI DR1P
COA COA O2 COA C171e
PI
H2O2
H2O H2O H2O PENN H2O

O2
HIUR ATN ATT UGC GLX NAD
BUTN ACP ACP ACP C180e
H2O H2O 2 H2O
H2O H2O UREA 2 NH3 CO2 ACP ACP ACP

C162 C162COA C182 C182COA C183ACP Incorporation of fatty acids from medium C192 C192COA
C181e
COA COA COA
Biosynthesis of precursors for glucolipids PPI AMP PPI AMP H2O COA Degradation of alkane amines PPI AMP
ATP ATP ATP
Folate biosynthesis NAD and NADPH biosynthesis CoA and pantothenate biosynthesis Biotin biosynthesis ACP ACP
C182e
DTBe DTB C180COA C171COA
C183 C183COA
SER SER
GTP ASP IMASP OIVALm 3 MALCOA
COA
C183e
PPI AMP
O2 H2O2 ATP
2 H2O T3P1 METTHF 4 NADPH COA COA

FOR PI THF CO2 CO2 C190e

4 NADP
3CPYRDe 3CPYRD 2 H2O C20DHSPH C191DHSPH
AHTD AKP 2 CO2

QUIN NADPH 2 COA

NADPH NADPH C191e
3 PI
PRPP NADP CHCOA NADP NADP

C192e
CHOR DHP PANT ALA
C20SPH C191SPH
GLN NAD H2O NADH
PPI ATP NADPH
QUINe QUIN
CO2 bALA COA
O2 C200e
GLU GLAL GLYA CO2
DMNAD NAMN 3CPYRD NADP
ADCHOR AHHMP AMP
H2O ATP
PPI
AONA 4.3.1.17
O2
KYNe KYN GLU GLN PPI ATP H2O
PPI H2O
AMP C20PSPH
ATP H2O2 SAM
PPI
PRPP PNTO
PI AMP
AMP
GLX H2O ADP H2O NH3 SAMOB
NICDe NICD PYR
NAD ATP
Biosynthesis of cerebrin 1 Biosynthesis of cerebrin 2 Biosynthesis of lanosterol Biosynthesis of zymosterol Biosynthesis of ergosterol Ergosterolester metabolism Glycerolipid metabolism Glycolipid metabolism Phosphatidylinositol biosynthesis BUTNe
NAMR NAR NICA DAONA Phosphatidylserine Phosphatidylethanolamine
PABA AHHMD ADP
PI
H2O CO2
C18PSPH C18PSPH C20PSPH C20PSPH C18SPH C18SPH C20SPH C20SPH AACCOA LNST ZYMST GL3P GL3P DAGLY C181COA
biosynthesis biosynthesis PENNe
ATP PI ATP
NICAe NICA COA Acyl-ACPs Acyl-ACPs G6P
C180COA C181COA C180COA C181COA C180COA C181COA C180COA C181COA 3 NADPH
SAM
H2O ADP
CYS ADP ACCOA 3 O2
UDPGAL UDPG
AMP H2O CTP PI
GL3P T3P2 GL3P T3P2
COA COA COA COA COA COA COA COA
PPI NADP
ACP ACP Acyl-ACPs Acyl-ACPs Acyl-ACPs Acyl-ACPs
NMN NICD CMP
UDP UDP
DTB COA 3 NADP
SAH
SEMAGP MAGLYP MAGLY 0.25 CLCDPDG
R5P PPI CERB1A CERB1B CERB1C CERB1D CERB2A CERB2B CERB2C CERB2D COA
H2O H2O NH3 4 H2O FEST Acyl-ACPs Acyl-ACPs MGDG MI1P 0.25 PECDPDG
DHPT S H3MCOA Acyls ACP ACP ACP ACP
4PPNCYS FOR H2O PI MGC181 0.25 PSCDPDG
GLU
2 NADPH UDPGAL PSAGL3P PSAT3P2 PEAGL3P PEAT3P2
0.25 CERB1A 0.25 CERB1B 0.25 CERB1C 0.25 CERB1D 0.25 CERB2A 0.25 CERB2B 0.25 CERB2C 0.25 CERB2D ACP 0.25 PCCDPDG Acyl-ACPs Acyl-ACPs
ATP DCTOL ACP
H2O ADPR 2 NADP H2O NADP NADPH NADP NADPH
BT SEDAGP UDP
ADP
COA NADPH DAGLYP DAGLY
PI
CO2
H2O DGDG MYOI CDPDG ACP ACP

MVL EPST Acyls PSPA PEPA

4PPNTE Acyl-ACPs H2O PI
DHF ATP NADPH
NADP
PI CTP CTP
ATP O2
NADPH
CERB1 DCDOL SEDAG ACP
H2O
CMP
PPI CERB2 ADP ERGOST r957 PINS
NADP 3 O2 PPI PPI
NADP TAGLYP TAGLY
DPCOA 3 NADPH PSCDPDG PECDPDG
THF PMVL 2 H2O

GLU
Biosynthesis of glucocerebrosides Biosynthesis of GPSL G SEMAG GL H2O PI SER SER
ATP 3 NADP
ATP ATP ERGOD ERGOSE
C91SPH C191SPH CERB2 4 H2O
H2O Acyls
CMP CMP
ADP ADP
C180COA C181COA Biosynthesis of galactocerebroside PINS ADP
DCDA NADPH
H2O PS PEPS
PI O2
CERB2A CERB2B
THFG COA COA COA PPMVL
UDPGAL UDPGAL Acyls Acyls
CEREB1 CEREB2 IPC ATP CO2
NADP

2 H2O ERGOST
Chitin biosynthesis Galactoglucomannan Phosphatidylcholine
UDP UDP biosynthesis biosynthesis CO2

UDPG UDPG GDPMAN CDOL PE LPE

ADP
ERGOT GL3P T3P2
GALCERA GALCERB PI 3 O2
UDP UDP
3 NADPH NADPH F6P 0.13 UDPG 0.435 GDPMAN 0.435 UDPGAL Acyl-ACPs Acyl-ACPs
CO2
0.5 GALCERA 0.5 GALCERB GLN Cardiolipin
GLUCER1 GLUCER2 MIPC IPPP DMPP 3 NADP
NADP
ACP ACP biosynthesis
4 H2O
GDPMAN GLU PCAGL3P PCAT3P2
ERGOST
Secondary metabolism CDA GA6P
0.565 UDP Acyl-ACPs
GL3P
ACCOA NADP NADPH
0.435 GDP Acyl-ACPs
ACP
DMIPC
GALCER
CO2 COA
GGM PCPA ACP
UDPGAL
GPP NAGA6P
ZYMST CTP
CLAGL3P
PHE UDP Acyl-ACPs
PPI
ACCOA PPI
GDMIPC Galactosaminogalactan ACP
4 MALCOA
UDPGAL FPP NAGA1P biosynthesis SER CLPA
5 COA UTP
CTP
UDP FPP
NADPH CMP

DGDMIPC PPI PCPS PPI

OTA NADP
UDPNAG UDPNAGAL CLCDPDG
UDPGAL
SQL Chitin hydrolysis GL3P
O2
UDP 0.064 UDPG 0.184 UDPNAGAL 0.752 UDPGAL CO2
NADPH AC H2O
UDP PCPE CMP
TGDMIPC
NADP CHITO CHIT CLPIGP
SAM
S23E H2O
UDP

H2O H2O GAG SAH

PI
NAG PCPMME
PG
H2O
SAM CLCDPDG
LNST
AC SAH CMP
GLCN PCPDME CL
ATP
SAM
Acyls
ADP
SAH
GA6P
PC LPC

OTAe