ASIM & SHOAIB (GYNAE & OBS.

)
Biochemistry
3. A requirement for conversion of Glucose-1-Phosphate to Glucose-6-Phosphate
a. ATP
b. NAD+
c. Fructose-1, 6-bisphosphatase
d. Glucose-1, 6-bisphosphatase
e. Phosphoglucose isomerase
pg34

14. Removal of some of Carbohydrate bound to serum proteins results in

a. aggregation and precipitation
b. Proteolysis by serum proteases
c. Rapid excretion by kidney
d. Rapid uptake and destruction by the liver
e. Their becoming antigenic
pg36

23. In Diabetes
a. conversion of extracellular glucose to intracellular glucose-6-phosphate decreases
b. glucose-6-phosphate activity increases
c. glucose utilization becomes independent of blood glucose concentration
d. glucose-6-phosphate activity decreases
e. glycogen synthesis decreases
pg38

24. Concerning pernicious anemia

a. cause by an inadequate intake of vitamin B12
b. caused by inadequate intake of iron
c. The gastric juice of patient is deficient in HCL and pepsin
d. The hemopoietic failure is caused by overproduction of a specific glycoprotein
e. Vitamin B12 is identified with intrinsic factor
pg38

Gynae & Obs

15. 42 year old para 3 reported with heavy cyclic vaginal bleeding for the last 6 months. Her clinical
examination was unremarkable. She had a recent D&C Histopathology showed early secretory phase
endometrium. What is the best standard first line of treatment
a. Anti-fibinolytic agents
b. Gn Rh analogeus
c. Mefenamic acid
d. Danazol
e. norethisterone
pg41
20. Hormones or substances synthesized by the kidneys include the following except
a. 1, 25 dihydroxycholecalciferol (vit D3)
b. Erythropoietin
c. Kinins
d. Prostaglandins
e. Renin
pg 42

61. Drug not useful in Dysmenorrhea is

a. Aspirin
b. Ibuprofen
c. Naproxen
d. Nevaquin-P
e. Piroxicam
pg51

76. During sexual excitement in female, fluids are secreted by vaginal walls mainly due to action of
a. Adrenaline
b. Bombesin
c. GnRH
d. Relaxin
e. VIP
pg54

97. Which of the following would be expected to reduce Maternal behavior

a. Hysterectomy
b. Lesions of the mediobasal hypothalamus
c. Lesions of occipital cortex
d. Loss of expression of the gene for fos-B
e. Ovariectomy
pg58

116. The most important physiological buffer in the blood is

a. Acetate Buffer
b. Bicarbonate Buffer
c. Haemoglobin buffer system
d. Phosphate buffer
e. Proteinate Buffer
pg62
131. The mean corpuscular volume ‘MCV’ is high in
a. Chronic blood loss
b. iron deficiency
c. pernicious anemia
d. sickle cell anemia
e. tahlasemia
pg65

132. First line of defence during bleeding is provided by

a. blood vessels
b. Coagulation inhibitors
c. Coagulation mechanism
d. fibrinolysis
e. platelets
pg65

144. The absorption of iron is adversely affected by except

a. Excess of phosphate, oxalates or phytic acid
b. Ingestion with citrus fruits
c. Ingestion with meals
d. Partial gastrectomy
e. The trivalent, Ferric form
pg67

146. After two abortions in first trimester patient reported during third pregnancy and is concerned
about the porsibility of recurrence of abortion. Change of recurrence
a. Depends about genetic make up of previous abortions
b. depends upon sex of previous conceptus
c. is more than 50%
d. Is not increased
e. Is upto 50%
pg68

222. The highest content of triglyceridies is present in

a. chylomicrons
b. high density lipoproteins
c. intermediate density lipoproteins
d. Low density lipoproteins
e. very low density lipoproteins
pg83
244. When a firm stroke with a pointed object is applied on the skin, there is spreading redness (flare)
due to arteriolar dilatation. This response is due to
a. Axon reflex
b. Histamine
c. Kinins
d. Mechanical stimulation
e. Tissue injury
pg87

256. Regarding allantois, Following statements are true except that it

a. contributes in development of cloaca
b. Doesn’t function in human embryos
c. Extend from the umbilicus to the urinary bladder
d. is purely endodermal in origin
e. Takes part in blood formation during third to fifth weeks
pg90

262. As compare to the male pelvis, the female pelvis has

a. A large pelvic outlet
b. narrow subpubic angle
c. A relatively shallow false pelvis with flaring of the ilia
d. An oval shaped pelvic inlet
e. Larger diagonal conjugate
pg91

274. The sacro iliac joint

a. has less mobility
b. Is a plain variety of synovial joint
c. is covered by psoas and iliacus
d. is innervated by ventral rami S1+S2 and lateral branches of dorsal rami S1+S2
e. Is supported by posterior division of external iliac artery
pg93

325. Leptin is a hormone produced from fats cells in the body. Its plasma level is higher in
a. Fasting
b. Increased cortisol secretion
c. Males
d. Obese persons
e. Hypothyroidism
pg103
342. Which of the following statements regarding vitamins is correct
a. All coenzymes contain vitamins or are vitamins
b. All vitamins can act as coenzymes
c. All water soluble vitamins act as coenzyme or coenzymes precursosrs
d. Ergosterol is provitamin A
e. Prostaglandins can be derived from fat soluble vitamins
pg107

346.Haemorrhagic disease of newborn is caused by the deficiency of vitamin K because

a. mother had malabsorption during pregnancy
b. normally the plasma concentration of vitamin K drops immediately after birth
c. Placenta does not pass the vitamin to the fetus
d. Prothrombin drops too low soon after birth in new born
e. The gut is sterile immediately after birth
pg108

347. Which of the Following is not a phospholipid

a. Cephalin
b. Gangliosides
c. Lecithin
d. Lysolecithin
e. Plasminogen
pg108

377. Increased urinary excretion of calcium mainly occurs in

a. Hyperparathyroidism
b. hyperthyroidism
c. Magnesium depletion
d. metabolic acidosis
e. Phosphate depletion
pg114

385. A 25 year old female presents with a typical chest pain, Dyspnoea on exertion and palpitations.
Clinical examination shows pulse rate 80/min, BP 130/80 mmHg , and a grade II systolic murmur at 4
sternal boder. ECG was normal, Chest X-ray normal. Which of the following is the most likely diagnosis
a. Aortic stenosis
b. Atrial septal defect
c. Coarctation of aorta
d. Normal Heart
e. Pulmonary stenosis
pg115
412. Meiosis is a type of cell division in which
a. DNA synthesis takes place
b. exchange of genetic material takes place in autosomes
c. one cell give rise to eight spermatozoa
d. take place in somatic cells
e. total number of chromosomes remain the same after the process is complete
pg121

467. Enzymes and co-enzymes are essential to life, each of the following serves as a cofactor for
enzymes except
a. ascorbic acid
b. Biotin
c. Copper
d. Pantothenic acid
e. Zinc
pg132

473. The rate of excretion of certain substances in the urine on a 24 hours basis can be used to estimate
the rate of muscle protein loss. Which of the following substances falls into the category
a. 3-Methyl histidine
b. Ammonia
c. None of above
d. Urea
e. Uric acid
pg133

522. Pelvic tuberculosis is

a. Most often bovine
b. Post secondary
c. Associated with amenorrhoea
d. precuasor of endometrial cancer
e. Decreasing in Pakistan
pg143

599. Premenstural syndrome is characterized by the following

a. Sudden weight loss
b. Lightness in breast
c. Bloating feeling
d. euphoria
e. Nauses, vomiting, backache
pg158
606. Essential tuberculosis
a. Can be diagnosed on X-ray
b. Amenorrhea is frequent presentation
c. Tubes are rarely involved
d. can be asymptomatic
e. Usually secondary
pg160

624. In cervix
a. Erosion can be symptomatic
b. Polyp is a malignant condition
c. Squamous metaplasia always leads to invasive carcinoma
d. Dyslplasia is a malignant condition
e. Carcinoma in situ is malignant condition
pg163

641. Carcinoma cervix is associated with the following

a. Multiparity
b. Nulliparity
c. Diabetes mellitus
d. hypertension
e. promiscuity
pg167

704. tubal patency test can be done by

a. Can not be done by laparoscopy
b. Blood test
c. Hysterosalpingography
d. MRI
e. Computerized tomography scan (C.T. Scan)
pg179

761. A 22 year old primigravida at 28 weeks of gestation has come for her first antenatal checkup, Scan
reveals an intact intra uterine pregnancy. Haematological Investigation reveals a low HB and abnormal
red cells. Which single further investigation will you perform at this stage to diagnose the type of
anaemia
a. Absolute values (MCV, MCH, MCHC, PCV)
b. Bone marrow biopsy
c. Hb electrophoresis
d. RBC count
e. Serum iron/ serum ferritin
pg191
789. Antenatal care helps in reducing
a. postnatal mortality
b. neonatal mortality
c. Postnatal morbidity
d. Congenital malformations
e. Gestational amenorrhea
pg196

793. Antenatal care:

a. Oral iron should be given as soon as patient missed her periods
b. pelvic examination should be done on first visit
c. Pelvic assessment should be done at 32 weeks
d. Tetanus toxoid should be given in 4 doses every 4 weeks from 22 weeks of pregnancy
e. Hb. And urine D/R should be done on each visit
pg197

Pathology
4. Omphalocele occurs due to failure of the bowel to return to the body cavity from its physiological
herniation during the following weeks
a. 11th – 13th week
b. 14th – 16th week
c. 17th – 20th week
d. 5th – 6th week
e. 6th – 10th week
pg210

6. The most common cause of gram negative infection in a patient with septic shock is the infection in
a. biliary tract
b. Colon
c. Small bowel
d. Tracheobronchial tree
e. Urinary tract
pg211

51. When no specific factor VIII concentrate available the next best source of factor VIII is
a. Albumin infusion
b. Cryoprecipitate
c. Packed cells
d. Platelet concentrate
e. Whole blood
pg220

122. The most important microscopic diagnostic criteria for premalignant lesions is
a. Enlargement of cells
b. High N.C ratio
c. mitotic figures
d. Pleomorphism
e. Presence of the nucleolus
pg234

132. One of the following not parasites transmitted by faecal oral route is
a. Entamoeba histolytica
b. Enterobius vermicularis
c. Giardia lamblia
d. trichinella spiralis
e. Troichuria trichuris
pg236

141. Following immunoglubulins are transferres from material to fetal circulation except
a. Ig A
b. Ig D
c. Ig E
d. Ig G
e. Ig M
pg238

157. One of the following is not a tumor markers

a. Alpha-fetoprotein
b. CEA (carcino-embryonic antigen)
c. HCG (human chorionic gonadotrophin)
d. PLAP (placental alkaline phosphate)
e. Prostatic acid phosphatase
pg241

162. One of the following condition is not in klinefelter’s syndrome

a. A lower incidence of mental retardation
b. A male phenotype
c. A raised urinary excretion of pituitary gonadotrophin
d. Gonadal dysgenesis
e. More than one X chromosome
pg242

167. Chronic inflammation results from

a. Acute inflammation in which the causative agents persist
b. Auto immune reaction
c. Infection by intracellular microorganisms
d. Persistent infection by organisms of low virulence
e. Repetitive bouts of acute inflammation
pg243
212. A 65 year old female had chronic obstructive airway disease. She develops fever and later on
septicemia due to salmonella infection. Her acid-base profile revealed pH 7.37 (7.35-7.45), pco2 (mmHg)
48 (35-45), Hco3 (mmol/l) 30 (23-29) The most likely biochemical diagnosis is
a. Fully compensated respiratory acidosis
b. Metabolic acidosis with metabolic alkalosis
c. Metabolic acidosis with respiratory alkalosis
d. Respiratory acidosis with metabolic alkalosis
e. Respiratory acidosis with respiratory alkalosis
pg252

216. A known case of rheumatic mitral stenosis develop fever, Lassitude, Body ache after tooth
extraction. Doctor is suspecting subacute bacterial endocarditis. The most likely organism present in
blood culture would be
a. H. Influenza
b. Staphylococus aureus
c. Strept. Faecalis
d. Strept. Pneumonia
e. Strept. Viridans
pg253

229. A new born baby develop fever, fits, neck rigidity and head retraction. The CSF examination show
counts mostly neutrophyls. The most likely organism present in CSF culture would be
a. haemophilus influenza
b. Neisseria meningitis
c. Staphylococeus aureus
d. Streptococus agalactiae
e. Streptococus pneumoniae
pg255

261. A 24 year female, six month pregnant, complains of generalized weakness and lethargy. Her Hb is
9.8 GM/dl , M.C.V. 58 FL and M.C.H 15 Peg. She probably has
a. Anaemia of chronic liver disease
b. folic acid deficiency
c. Iron-Deficiency anemia (WHY NOT ??)
d. Megaloblastic anemia
e. Thalassemia major
pg262

267. In true hermaphroditism, the genetic configuration is

a. XO
b. XX
c. XX/XY
d. XXY
e. XY
pg263
284. Pedigree analysis is essential in ascertaining some inherited disorders. The “Proband” is one of the
following
a. The affected person who presents for medical attention
b. The offspring of the person who presents
c. The person who presents for medical attention, whether affected or unaffected
d. The suppose of the concerned individual
e. The unaffected parent who presents for medical attention
pg266

294. CD4+TH cells have at least two different profiles of cytokine production, TH1 and TH2. TH1
cytokines do not include
a. IL-12
b. IL-2
c. Interferon-gamma (IFN-Gamma)
d. Interleukin (IL-4)
e. Tumor necrosis factor beta (TNF-Beta)
pg268

322. 25 year old girl with fever and ESR 40 in operated for right adnexal mass. She is found to have right
fallopian tube distorted and covulated round right ovary. During dissection it ruptured and white cheesy
material came out. The most likely diagnosis is
a. Aqute salpingitis
b. Dermoid Cyst
c. Mucinous cyst adenoma
d. Pyosalpinx
e. tuberculos salpingitis
pg274

360. A woman was admitted in hospital suffering from puerpueral sepsis. The lochia was sent for
Bacteriological examination. The most likely organism for this sepsis is
a. Bacteroides
b. Candida albicans
c. Lacto bacillus
d. Mixed bacterial infection
e. Proteus mirabilis
pg281

Pharmacology

29. Propranolol differs from atenolol in having

a. Less membrane stability activity
b. Less first pass effects
c. Lesser lipid solubility
d. Equal effects on beta-1 and beta-2 receptors
e. More effects on periphery nervous system
pg300
 Physiology

12. Mole for mole..which of the following has greatest effect on Na excretion?
a. ANP
b. Aldosterone
c. Cortisol
d. Progesterone
e. Vasopressin
pg307

23. Stimulus increasing aldosterone secretion without affecting glucocorticoid secretion include
a. Anxiety
b. Haemorrhage
c. Low potassium intake
d. Physical trauma
e. Surgery
pg309

42. A 32 year old obese male complains of rapid heart rate, 9kg weight loss in 2 months and heat
intolerance. His pulse is 110/min Serum T4 is elevated. On questioning he admits that he is using
Thyroxine tablets to lose weight. The parameter which shows an increase is
a. Serum T3
b. Serum T4
c. Serum TSH
d. Serum free T3
e. Serum free T4
pg313

101. Development of Alveoli and lobules in the breast is primarily by

a. Cortisol
b. Estrogens
c. Human chorionic somatomamotropin
d. Progesterone
e. Prolactin
pg325

PLZ Remember Dr. Goshi in your prayers

BEST OF LUCK