COSHH Assessment of Tablet assay

 Before planning an analysis (experiment), assess the hazards and potential risks associated with the chemicals and laboratory operations to be used.
 The chemicals encountered in the laboratory have a broad spectrum of physical, chemical, and toxicological properties and physiological effects. The risks
associated with chemicals must be well understood prior to their use in an experiment.
 In spite of guidelines and staff supervision, the primary responsibility for safety rests with the individual performing an analysis (experiment).

Chemical Risks Precautions/controls Storage Disposal

Anhydrous dibasic 1. Emergency Overview : Eye Contact Keep containers tightly As per SOP :
sodium phosphate May cause eye, skin, and respiratory tract Rinse immediately with plenty of water, also closed in a dry, cool Handling of chemical, spillage,
irritation. under the eyelids, for at least 15 minutes. and well-ventilated and dispose off laboratory
Obtain place. chemical waste.
2. Hazards identification : medical attention.
Target Organs : Kidney
Skin Contact
3. Potential Health Effects Wash off immediately with plenty of water for
Acute Effects at least 15 minutes. Get medical attention
Principle Routes of Exposure immediately if symptoms occur.

Eyes Inhalation
May cause irritation Move to fresh air. If breathing is difficult, give
oxygen. Get medical attention immediately if
Skin symptoms occur.
May cause irritation. May be harmful in contact
with skin. Personal Protective Equipment
Eye/face Protection
Inhalation Wear appropriate protective eyeglasses or
May cause irritation of respiratory tract. May be chemical safety goggle.
harmful if inhaled.
Skin and body protection
Ingestion Wear appropriate protective gloves and
May be harmful if swallowed. Ingestion may clothing to prevent skin exposure.
cause gastrointestinal irritation, nausea,
vomiting and diarrhea.

Chronic Effects
May cause adverse kidney effects

Methanol 1. Hazards identification : Prevention Keep container tightly As per SOP :

Physical hazards P210 - Keep away from heat/sparks/open closed in a dry and Handling of chemical, spillage,
Flammable liquids - Category 2 flames/hot surfaces. - No smoking well-ventilated place. and dispose off laboratory

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Health hazards
Acute oral toxicity - Category 3
Acute dermal toxicity - Category 4
Acute Inhalation Toxicity - Vapors Category 3
Specific target organ toxicity - (single exposure)
Category 1
Hazard Statements
H225 - Highly flammable liquid and vapor
H301 - Toxic if swallowed
H311 - Toxic in contact with skin
H331 - Toxic if inhaled
H370 - Causes damage to organs
Substance is not considered to be persistent,
bioaccumulative and toxic (PBT). Substance is
not considered to be very persistent and very
bioaccumulative (vPvB).
Most important symptoms and effects,
both acute and delayed
Breathing difficulties. May cause blindness:
Inhalation of high vapor concentrations may
cause symptoms like headache, dizziness,
tiredness, nausea and vomiting.
Indication of any immediate medical
attention and special treatment needed
Notes to Physician Treat symptomatically.
Symptoms may be delayed.
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P280 - Wear protective gloves/ protective Keep away from open chemical waste.
clothing/ eye protection/ face protection flames, hot surfaces
P301 + P310 - IF SWALLOWED: and sources of ignition.
Immediately call a POISON CENTER or Flammables area
doctor/ physician
P302 + P350 - IF ON SKIN: Gently wash
with plenty of soap and water
P304 + P340 - IF INHALED: Remove to
fresh air and keep at rest in a position
comfortable for breathing
P240 - Ground/Bond container and receiving
equipment.
FIRST AID MEASURES
General Advice
Immediate medical attention is required.
Show this safety data sheet to the doctor in
attendance.
Eye Contact
Rinse immediately with plenty of water, also
under the eyelids, for at least 15 minutes. In
the case of contact with eyes, rinse
immediately with plenty of water and seek
medical
advice.
Skin Contact
Wash off immediately with plenty of water for
at least 15 minutes. Immediate medical
attention is required.
Ingestion
Do not induce vomiting. Call a physician or
Poison Control Center immediately.
Inhalation
Move to fresh air. If breathing is difficult, give
oxygen. Do not use mouth-to-mouth method
if
victim ingested or inhaled the substance; give
artificial respiration with the aid of a pocket
mask equipped with a one-way valve or other
 proper respiratory medical device. Immediate
medical attention is required.

Protection of First-aiders Ensure that

medical personnel are aware of the
material(s) involved, take precautions to
protect themselves and prevent spread of
contamination. Use personal protective
equipment. Avoid contact with skin, eyes and
clothing. Remove all sources of ignition. No
artificial respiration, mouth-to-mouth or
mouth to nose. Use suitable
instruments/apparatus.
Avoid contact with skin.

Environmental precautions
Should not be released into the environment.

Methods and material for containment

and cleaning up
Soak up with inert absorbent material. Keep
in suitable, closed containers for disposal.
Remove all sources of ignition. Use
spark-proof tools and explosion-proof
equipment

Paracetamol Hazard(s) identification PREVENTION Keep container tightly

closed in a dry and As per SOP :
Physical hazards Wash thoroughly after handling. Do not eat, well-ventilated place. Handling of chemical, spillage,
Not classified. drink or smoke when using this product. and dispose off laboratory
chemical waste.
Health hazards FIRST AID MEASURES
Acute toxicity, oral Category 4
Skin contact
OSHA hazard(s) Immediately flush skin with plenty of water.
Not classified. Get medical attention if irritation develops
andpersists.
Label elements
Signal word Warning Eye contact
Rinse with water. Get medical attention if
Hazard statement irritation develops or persists.
Harmful if swallowed.
Ingestion

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 Rinse mouth. IF SWALLOWED: Call a
POISON CENTER or doctor/physician if you
feel unwell
Potassium phosphate Keep container tightly
dibasic anhydrous Hazard(s) identification closed. Keep container As per SOP :
Eye Contact: in a cool, well- Handling of chemical, spillage,
Check for and remove any contact lenses. In First Aid Measures ventilated area. and dispose off laboratory
case of contact, immediately flush eyes with Eye Contact: Hygroscopic chemical waste.
plenty of water for at least 15 minutes. Cold Check for and remove any contact lenses. In
water may be used. Get medical attention if case of contact, immediately flush eyes with
irritation occurs. plenty of water for at least 15 minutes. Cold
Skin Contact: water may be used. occurs.
Wash with soap and water. Cover the irritated
skin with an emollient. Get medical attention if Skin Contact:
irritation develops. Cold water may be used. Wash with soap and water. Cover the
Inhalation: irritated skin with an emollient. Cold water
If inhaled, remove to fresh air. If not breathing, may be used. Serious Skin Contact
give artificial respiration. If breathing is difficult, : Not available.
give oxygen. Get medical attention. Do NOT Inhalation:
induce vomiting unless directed to do so by If inhaled, remove to fresh air. If not
medical personnel. Never give anything by breathing, give artificial respiration. If
mouth to an unconscious person. breathing is difficult, give oxygen. Get
medical attention.

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