Skin Dz.

Multiple Choice Questions

Question 1. Which one of the following is the correct statement about cryoglobulins?
A Samples for cryoglobulin detection must be stored on ice before they reach the laboratory.
B Type III cryoglobulins are associated with hepatitis C infection.
C Type I cryoglobulins are monoclonal proteins typically of IgA or IgD class.
D Cryoglobulins are always monoclonal immunoglobulins.
Question 2. Which one of the following statements relating to infections in the skin is true?
A Skin granulomas are rare in Mycobacterium leprae infections
B Human papilloma virus (HPV) is associated with a reactive, non-infective skin rash
C The measles rash is infective
D Recurrent herpes labialis is caused by reactivation of persistent herpes simplex infection often
provoked by exposure to UV light
E Atopic individuals have an increased tendency to varicella zoster virus (VZV)
Question 3. Which one of the statements about allergic contact dermatitis is true?
A Allergic contact dermatitis is best diagnosed by intra-dermal prick testing.
B Contact dermatitis is common in atopic individuals
C The sensitizing agents are usually of relatively high molecular weight (>12 kDa)
D A clinical diagnosis of contact dermatitis depends on a careful medical history and the distribution
of the lesions.
Question 4. A normal C4 concentration during an episode of angioedema usually excludes a
diagnosis of hereditary angioedema (HAE).
A True
B False
Question 5. Which one of these statements in relation to bullous skin diseases is FALSE?
A In the bullous skin eruptions, the edge of established bullae should be biopsied for direct
immunofluorescent examination
B Pemphigus vulgaris is the least serious of the bullous skin disorders
C Pemphigus vulgaris is a disease of younger individuals ? usually 20?40 years
D Pemphigus vulgaris blisters occur within the dermis
E The main antigenic target the autoantibodies in pemphigoid is the adhesion molecule, desmoglein
3.

Question 6. Which one of the following statements about discoid lupus erythematosus is true?
A The skin lesions rarely, if ever, scar
 B Only 20% of the patients with this condition have antibodies to dsDNA
C The lupus band test typically shows granular deposits of immunoglobulin at the dermoepidermal
junction of unaffected skin
D Systemic involvement is rare
Question 7. Which one of the following clinical features is NOT commonly found in limited
systemic sclerosis?
A Raynaud's phenomenon
B Oesophageal dysfunction
C Eczema
D Sclerodactyly
E Telangiectasia
Question 8. Which one of the following cell types is known to play important roles in the
pathogenesis of allergic contact dermatitis?
A B lymphocytes
B Desmosomes
C NK cells
D T cells
Question 9. Circulating autoantibodies to skin antigens may be diagnostically helpful in which
one of the following conditions?
A Pemphigus vulgaris
B Alopecia areata
C Allergic contact dermatitis
D Subacute cutaneous lupus erythematosus
Question 10. Langerhans’ cells are intra-epidermal antigen-presenting cells.
A True
B False

Question 11. Which one of the following statements about psoriasis is true?

A Psoriasis is a rare skin disease

B Important risk factors for psoriasis include alcohol and recreational drugs
C Psoriasis is a disease of younger individuals
D The disease is limited to the skin
E The currently approved biologic therapies include the TNF-alpha inhibitors and IL-12 inhibitors.