Pharmacology questions

1. Identical doses of a drug are given orally and intravenously. Periodically blood samples
were taken for measuring the concentration of drug and data is plotted as shown in figure

Further analysis of only these data will allow you to determine which of the following

A. Elimination route
B. Oral bioavailability
C. Potency
D. Therapeutic effectiveness

2. Prescription drugs are included in:

A. Schedule C of drugs & Schedule C of Drugs & Cosmetic Act
B. Schedule H of drugs & Schedule C of Drugs & Cosmetic Act
C. Schedule P of drugs & Schedule C of Drugs & Cosmetic Act
D. Schedule X of drugs & Schedule C of Drugs & Cosmetic Act
3. Drugs which can cause pseudo lymphoma are all except?
A. Phenytoin
B. Furosemide
C. Diphenhydramine
D. Procainamide
4. Drug which can cause Hypertrophic Pyloric Stenosis is?
A. Rifampicin
B. Erythromycin
C. Azithromycin
D. Ampicillin
5. Safest antimalarial drug during pregnancy is
A. Mefloquine
B. Pyrimethamine
 C. Proguanil
D. Quinine
6. Metrifonate is effective against
A. Amoebiasis
B. Leishmaniasis
C. Schistosomiasis
D. Giardiasis
7. Which of the following drugs causes an uncontrollable tendency to fall asleep at
inappropriate time?
A. Pramipexole
B. Methylphenidate
C. Dipyridamole
D. Memantine
8. Which of the following drugs results in thrombocytopenia due to drug-antibody reaction?
A. Aspirin
B. Quinine
C. Metronidazole
D. Artesunate
9. Local anaesthetic with vasodilatory property include all except?
A. Cocaine
B. Lidocaine
C. Mepivacaine
D. Prilocaine
10. Which of the following drug causes capillary leak syndrome?
A. GM-CSF
B. GCSF
C. Filgrastim
D. Peg Filgrastim
11. Pregnant woman is on valproate for juvenile myoclonic epilepsy. Alternative
monotherapy of choice is
A. Carbamazepine
B. Phenytoin
C. Levetiracetam
D. Lacosamide
12. Which statin is given to an 8 year old child with heterozygous familial
hypercholesterolemia?
A. Simvastatin
B. Pravastatin
C. Atorvastatin
D. Lovastatin
13. Antiepileptic drug of choice in child treated with ketogenic diet?
 A. Carbamazepine
B. Phenytoin
C. Valproate
D. Lamotrigine
14. Drug of choice for acute adrenal crisis is
A. Norepinephrine
B. Hydrocortisone
C. Dexamethasone
D. Fludrocortisone
15. A 65 year male with hypertension treated with maximum doses of hydrochlorothiazide &
ramipril presents to your office with a persistently elevated BP of approximately 160/100
& a heart rate of 56 bpm. You considering adding a 3rd antihypertensive drug to his
treatment regimen, but you are concerned about his prolonged AV conduction time on
ECG. Which of the following drug is most appropriate in this patient?
A. Verapamil
B. Metoprolol
C. Diltiazem
D. Nifedipine
16. INSTI approved for the treatment of HIV is
A. Dolutegravir
B. Indinavir
C. Tenofovir
D. Maraviroc
17. The house officer considers prescribing nadolol for a 53-year-old patient. What
preexisting condition (comorbidity) would most likely contraindicate safe use of this
drug?
A. Effort angina
B. Hypertension
C. Asthma
D. CHF
18. All of the following can be used for the treatment of Gestational DM, except?
A. Glyburide
B. Metformin
C. Insulin
D. Acarbose
19. All of the following are enzyme inhibitors, except?
A. Erythromycin
B. Verapamil
C. St.Jhon’s wort
D. Grapefruit juice
20. Which is not used in the treatment of heroin dependence?
 A. Disulfiram
B. Buprenorphine
C. Clonidine
D. Lofexidine
21. Drugs approved for the treatment of Opioid induced constipation are all except?
A. Naloxegol
B. Methylnaltrexone
C. Lubiprostone
D. Linaclotide
22. A 55-year-old man presents with gradually increasing shortness of breath and leg
swelling that occurred while on a business trip. He has congestive heart failure, which has
caused fatigue and shortness of breath if he walks a block or climbs a flight of stairs. BP
is 140/90; there is no jugular venous distension or gallop, and only minimal pedal edema.
An echocardiogram shows left ventricular ejection fraction is 45%. Current medications
include aspirin and simvastatin. The patient desires to keep medications to a minimum.
What additional treatments are indicated at this time?
A. Spironolactone
B. ACE inhibitor
C. β-blocker
D. Furosemide
23. A 60 year old male treated with high dose methotrexate experiences fever, painful mouth
ulcers & pancytopenia. Which of the following agents could have prevented this patient’s
condition?
A. Folinic acid
B. Filgrastim
C. Mesna
D. Amifostine
24. Which of the following drugs is not used in Juvenile Myoclonic Epilepsy (JME)
A. Topiramate
B. Zonisamide
C. Carbamazepine
D. Valproate
25. Drugs that prolong QT interval include all except?
A. Erythromycin
B. Haloperidol
C. Terfenadine
D. Metformin
26. Which of the following side effects is most likely to occur in slow acetylators on
treatment with INH for pulmonary tuberculosis?
A. Peripheral neuropathy
B. Hepatotoxicity
 C. Thrombocytopenia
D. Nephrotoxicity
27. Three α-agonist drugs are tested as potential vasoconstrictors. The degree of
vasoconstriction is determined by measuring the cross-sectional area of an isolated vessel
after application of the drug. The following curves are obtained

Which of the following is the best statement concerning the effects of these drugs?

A. Drug 1 has lower potency than drug 2

B. Drug 2 has higher affinity for α-receptors than Drug 3
C. Drug 1 demonstrates the highest efficacy
D. Drug 2 & Drug 3 demonstrate a similar potency

28. Which of the following teratogenic effects are incorrectly matched

A. Phenytoin – Cleft palate, hare lip
B. Zidovudine- Skull defects
C. Valproate- Neural tube defects
D. Warfarin- Nasal bone dysplasia
29. The Antidote used for the reversal of Dabigatran is
A. Idarucizumab
B. Bevacizumab
C. Ipilimumab
D. Trastuzumab
30. Which among the following is not a prodrug?
A. Enalapril
 B. Oxcarbazepine
C. Droxidopa
D. Diazepam
31. All of the following are antipseudomonal cephalosporins except?
A. Ceftazidime
B. Cefoperazone
C. Cefpodoxime
D. Cefpirome
32. Drugs that may increase the anticoagulant effect of warfarin include all of the following
except?
A. Amiodarone
B. Fluconazole
C. Co-trimoxazole
D. Cholestyramine
33. Which one of the following drugs does not cause SIADH?
A. Cyclophosphamide
B. Carbamazepine
C. Chlorpromazine
D. Cisplatin
34. Which of the following is a plasma expander similar to the albumin, has a molecular
weight of 30000 & causes less hypersensitivity reactions but should be used with
caution?
A. Hydroxy ethyl starch
B. Dextran
C. Polygeline
D. Polypyrrolidone
35. Methacholine is a
A. M1 receptor agonist
B. M2 receptor agonist
C. M3 receptor agonist
D. M4 receptor agonist
36. Which of the following Antitubercular drug is associated with hypothyroidism?
A. Rifampicin
B. Pyrazinamide
C. Ethionamide
D. Streptomycin
37. Duration of action of flumazenil is?
A. 10 min
B. 20 min
C. 30 min
D. 40 min
38. A hypertensive patient on medication with β-blocker develops bradycardia & sweating on
taking medication. Which of the following is least likely cause for this
A. Nadolol
B. Metoprolol
C. Acebutolol
D. Atenolol
39. All of the following are used in the treatment of pulmonary hypertension, except?
A. Iloprost
B. Treprostinil
C. Finasteride
D. Selexipag
40. Antiplatelet drug which acts as an antagonist at protease-activated receptor-1 (PAR-1) is;
A. Vorapaxar
B. Abciximab
C. Eptifibatide
D. Ticagrelor
41. Which of the following drug is not given in acute mania?
A. Lithium
B. Lamotrigine
C. Valproate
D. Olanzapine
42. Which is not a pleiotropic effect of statins?
A. Reduce LDL cholesterol
B. Improve endothelial stability
C. Antioxidant/anti-inflammatory
D. Reduce plaque rupture
43. Administration of disulfiram in an alcoholic can cause all these side effects except?
A. Flushing
B. Headache
C. Hypertension
D. Nausea
44. Selective β3 agonist used in the treatment of overactive bladder is?
A. Propiverine
B. Mirabegron
C. Solifenacin
D. Fesoterodine
45. Intranasal calcitonin is used for:
A. Postmenopausal osteoporosis
B. Paget’s disease
C. Secondary hypoparathyroidism
D. Hypercalcemia
46. Antihelminthic contraindicated in seizure disorder is
A. DEC
B. Albendazole
C. Piperazine
D. Pyrantel pamoate
47. New drug approved for the treatment of advanced soft tissue sarcoma (Leiomyosarcoma):
A. Eribulin
B. Trabectedin
C. Cabazitaxel
D. Ixabepilone
48. All of the following statements about treatment of migraine are true except?
A. Narotriptan has slower onset & longer t1/2 than Sumatriptan
B. Rizatriptan is more efficacious than sumatriptan
C. Sumatriptan is a selective 5-HT 1B/1D agonist
D. Sumatriptan is used for chronic migraine
49. Drug emerging as the agent of choice for initial treatment of Tourette syndrome
A. Haloperidol
B. Valproate
C. B Complex
D. Clonidine
50. Which of the following is the best inotropic agent for use in right heart failure secondary
to pulmonary hypertension?
A. Dobutamine
B. Digoxin
C. Milrinone
D. Halothane
51. All of the following agents are used in the treatment of hot flushes except?
A. Tamoxifen
B. Venlafaxine
C. Gabapentin
D. Paroxetine
52. Hemodialysis is useful in poisoning with all of the following except?
A. Lithium
B. Ethylene glycol
C. Salicylate
D. Benzodiazepines
53. All of the following are used in the treatment of multiple sclerosis except?
A. Dimethyl fumarate
B. Alemtuzumab
C. Teriflunomide
D. Thalidomide
54. All of the following are approved for the treatment of obesity except?
A. Lorcaserin
B. Liraglutide
C. Phentermine/topiramate (FDC)
D. Desvenlafaxine
55. All of the following drugs are used for the treatment of insomnia except?
A. Zolpidem
B. Fluoxetine
C. Ramelteon
D. Suvorexant
56. All of the following drugs are used in the treatment of chronic alcoholism except?
A. Acamprosate
B. Chlordiazepoxide
C. Disulfiram
D. Naltrexone
57. All of the following statements are true about Bedaquiline except?
A. Acts by inhibiting ATP synthase in mycobacteria
B. No cross-resistance with other anti-TB drugs
C. Associated with both hepatotoxicity & cardiac toxicity
D. Should be given on an empty stomach
58. Which of the following antibiotics can be used in the treatment of fungal keratomycosis?
A. Silver sulfadiazine
B. Linezolid
C. Vancomycin
D. Doxycycline
59. A 30 year old man presents to the emergency with c/o muscle weakness, nausea,
vomiting & fatigue. ECG showed tall peaked T waves, prolonged PR interval, wide QRS
& absent P wave. Which of the following drugs is not used in management?
A. β-blockers
B. Sodium bicarbonate
C. Calcium gluconate
D. Insulin
60. Time dependent killing & prolonged post-antibiotic effect is seen with
A. Fluoroquinolones
B. β-Lactam antibiotics
C. Clindamycin
D. Erythromycin
61. The beneficial effect of nitrates in angina is primarily due to
A. Increase coronary blood flow
B. Reduction of cardiac preload
C. Reduced force of contraction
 D. Reduced afterload
62. Treatment of choice for Kawasaki disease is
A. Immunoglobulins
B. Corticosteroids
C. Azathioprine
D. Methotrexate

63. All of the following are known to cause lupus like syndrome except?
A. INH
B. Penicillin
C. Hydralazine
D. Sulfonamide
64. Which of the following drug is contraindicated in patients with HOCM
A. β-blockers
B. Verapamil
C. Digitalis
D. Amiodarone
65. Emergence delirium is seen with
A. Midazolam
B. Ketamine
C. Thiopentone
D. Opioids
66. Anti-CTLA-4 used in the treatment of metastatic melanoma is
A. Vemurafenib
B. Ipilimumab
C. Trametinib
D. Adalimumab
67. Uptake I & II inhibited by
A. COMT inhibitors
B. Cocaine
C. MAO Inhibitors
D. Phenoxybenzamine
68. The following drugs may be used in erectile dysfunction except?
 A. Phenylephrine
B. Apomorphine
C. Alprostadil
D. PGE1 analogues
69. All of the following drugs will cause seizures except?
A. Methotrexate
B. Vincristine
C. Asparaginase
D. Cyclophosphamide
70. Clonidine is indicated in each of the following conditions except?
A. Cardiac arrhythmias
B. Morphine withdrawal
C. Migraine
D. Hypertension
71. All the following drugs act on cell wall except?
A. Cefixime
B. Fosfomycin
C. Teicoplanin
D. Daptomycin
72. Drugs used to eradicate carrier state in meningococcal infections include all except?
A. Rifampin
B. Ceftriaxone
C. Ciprofloxacin
D. Roxithromycin
73. All of the following drugs are used for the treatment of tuberculosis in pregnancy except?
A. Isoniazid
B. Rifampin
C. Ethambutol
D. Pyrazinamide
74. Drug used for the prevention of hypoglycemia in patient with insulinoma before surgery?
A. Diazoxide
B. Propranolol
C. Prednisone
D. Dextrose
75. Which parenteral iron preparation is associated with higher risk of anaphylaxis?
A. Iron-sorbitol-citric acid
B. Iron-dextran
C. Ferrous-sucrose
D. Ferric carboxymaltose
76. Drug used for the treatment of chronic & accelerated phase CML after failure of 2 or
more TKIs (Tyrosine kinase inhibitors)
A. Omacetaxine
B. Omecamtiv mecarbil
C. Oncovin
D. Oxaliplatin
77. A previously healthy 45 year old male undergoes an elective hernia repair under spinal
anaesthesia. Post operatively he complains of difficulty in voiding urine. Bladder
catheterization shows post-void residual volume of 300cc. The patient would likely to get
benefit from which of the following medication?
A. Finasteride
B. Bethanechol
C. Phenylephrine
D. Oxybutynin
78. Which of the following does not cause Gynaecomastia?
A. INH
B. Cimetidine
C. Digoxin
D. Pyrazinamide
79. Sympathomimetic drugs are useful in the treatment of all the following conditions
except?
A. Acute decompensated heart failure
B. Hypotension
C. Hypertension
D. Erectile dysfunction
80. All the following drugs are used in cardiogenic shock except?
A. Atropine
B. Nitroglycerine
C. Morphine
D. Aspirin
81. Which one among the following is not bound to Alpha1 acid glycoprotein?
A. Procainamide
B. Disopyramide
C. Quinidine
D. Propranolol
82. A patient has subclinical folate deficiency. All of the following drugs can precipitate
Megaloblastic anemia except?
A. Alcohol
B. Phenytoin
C. Chloroquine
 D. Sulfasalazine
83. Reduction of renal blood flow is seen with use of
A. Osmotic diuretics
B. Loop diuretics
C. Acetazolamide
D. All the above
84. Using maintenance dose full therapeutic effect of digoxin is seen at
A. 1 week
B. 2 weeks
C. 3 weeks
D. 4 weeks
85. Which of the following drug decreases plasma renin activity?
A. Enalapril
B. Nifedipine
C. Hydralazine
D. Clonidine
86. Bexarotene, an oral retinoid indicated in
A. Severe acne vulgaris
B. Pustular psoriasis
C. Mycosis fungoides
D. Lichen planus
87. Pharmacological closure of patent ductus arteriosus in a premature infant is done by
using
A. Aspirin
B. Estrogen
C. Ibuprofen
D. Indomethacin
88. The only atypical antipsychotic drug that is indicated to reduce the risk of suicide is
A. Clozapine
B. Ziprasidone
C. Risperidone
D. Asenapine
89. Restless leg syndrome is commonly caused by an addiction to which of the following
A. Caffeine
B. Cocaine
C. Cannabis
D. Opium
90. Drug effective for the treatment of common gram-negative anaerobes
A. Aztreonam
B. Doxycycline
C. Vancomycin
 D. Tobramycin
91. A 16-year-old girl treated for asthma develops drug-induced skeletal muscle tremors.
What was the most likely cause?
A. Albuterol
B. Beclomethasone
C. Cromolyn
D. Ipratropium
92. A 30-year-old woman being treated for ovarian cancer develops high frequency hearing
loss and declining renal function in response to anticancer drug therapy. Which drug is
the most likely cause?
A. Bleomycin
B. Cisplatin
C. Doxorubicin
D. 5-FU
93. A patient on antimicrobial therapy develops the following signs and symptoms that
ultimately are found to be drug-induced: cough, dyspnea, and pulmonary infiltrates;
neutropenia and bleeding tendencies; and paresthesias. What was the most likely cause of
this patient’s symptoms?
A. Amoxicillin
B. Azithromycin
C. Ciprofloxacin
D. INH
94. Tibolone is a
A. SSRI
B. SPRM
C. STEAR
D. SERM
95. A patient has periodic episodes of paroxysmal supraventricular tachycardia (PSVT).
What drug would be most suitable for outpatient prophylaxis of these worrisome
electrophysiological events?
A. Adenosine
B. Lidocaine
C. Nifedipine
D. Verapamil
96. Reslizumab a humanized MAB indicated for add-on maintenance treatment of patients
with severe asthma aged 18 years and older, with an eosinophilic phenotype. It targets
A. IL-2
B. IgE
C. IL-5
D. TNF-α
97. An orally active steroid prodrug that is used for the treatment of refractory prostate
cancer.
A. Trilostane
B. Abiraterone
C. Metyrapone
D. Mitotane
98. Selective decrease in IgA is seen with administration of
A. Phenytoin
B. Diazepam
C. Clonazepam
D. Phenobarbitone
99. All of the following drugs cause acute pancreatitis except?
A. Azathioprine
B. Valproic acid
C. Sulfonamides
D. Phenacetin abuse
100. Which of the following agents is not associated with Hyperthermia
A. Amphetamine
B. MAO inhibitors
C. Atropine
D. Alcohol